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Cytotoxic alkaloids and antibiotic nordammarane triterpenoids from the marine-derived fungus Aspergillus sydowi.
J Nat Prod. 2008 Jun; 71(6):985-9.JN

Abstract

Three new diketopiperazine alkaloids, 6-methoxyspirotryprostatin B (1), 18-oxotryprostatin A (2), and 14-hydroxyterezine D (3), with an oxaspiro[4.4]lactam moiety, 14-norpseurotin A (4), and the 29-nordammarane triterpenoid 6beta,16beta-diacetoxy-25-hydroxy-3,7-dioxy-29-nordammara-1,17(20)-dien-21-oic acid (5), as well as 12 known compounds (6- 17), were isolated from the ethyl acetate extract of a marine-derived fungal strain, Aspergillus sydowi PFW1-13. The structures of compounds 1- 5 were elucidated by comprehensive spectroscopic analysis. Compounds 1- 3 exhibit weak cytotoxicity against A-549 cells, with IC 50 values of 8.29, 1.28, and 7.31 microM, respectively. Compound 1 also shows slight cytotoxicity against HL-60 cells, with an IC 50 value of 9.71 microM. Compounds 4 and 5 display significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 microM and 10.65, 5.33, and 10.65 microM, respectively.

Authors+Show Affiliations

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18505285

Citation

Zhang, Min, et al. "Cytotoxic Alkaloids and Antibiotic Nordammarane Triterpenoids From the Marine-derived Fungus Aspergillus Sydowi." Journal of Natural Products, vol. 71, no. 6, 2008, pp. 985-9.
Zhang M, Wang WL, Fang YC, et al. Cytotoxic alkaloids and antibiotic nordammarane triterpenoids from the marine-derived fungus Aspergillus sydowi. J Nat Prod. 2008;71(6):985-9.
Zhang, M., Wang, W. L., Fang, Y. C., Zhu, T. J., Gu, Q. Q., & Zhu, W. M. (2008). Cytotoxic alkaloids and antibiotic nordammarane triterpenoids from the marine-derived fungus Aspergillus sydowi. Journal of Natural Products, 71(6), 985-9. https://doi.org/10.1021/np700737g
Zhang M, et al. Cytotoxic Alkaloids and Antibiotic Nordammarane Triterpenoids From the Marine-derived Fungus Aspergillus Sydowi. J Nat Prod. 2008;71(6):985-9. PubMed PMID: 18505285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic alkaloids and antibiotic nordammarane triterpenoids from the marine-derived fungus Aspergillus sydowi. AU - Zhang,Min, AU - Wang,Wen-Liang, AU - Fang,Yu-Chun, AU - Zhu,Tian-Jiao, AU - Gu,Qian-Qun, AU - Zhu,Wei-Ming, Y1 - 2008/05/28/ PY - 2008/5/29/pubmed PY - 2008/9/16/medline PY - 2008/5/29/entrez SP - 985 EP - 9 JF - Journal of natural products JO - J Nat Prod VL - 71 IS - 6 N2 - Three new diketopiperazine alkaloids, 6-methoxyspirotryprostatin B (1), 18-oxotryprostatin A (2), and 14-hydroxyterezine D (3), with an oxaspiro[4.4]lactam moiety, 14-norpseurotin A (4), and the 29-nordammarane triterpenoid 6beta,16beta-diacetoxy-25-hydroxy-3,7-dioxy-29-nordammara-1,17(20)-dien-21-oic acid (5), as well as 12 known compounds (6- 17), were isolated from the ethyl acetate extract of a marine-derived fungal strain, Aspergillus sydowi PFW1-13. The structures of compounds 1- 5 were elucidated by comprehensive spectroscopic analysis. Compounds 1- 3 exhibit weak cytotoxicity against A-549 cells, with IC 50 values of 8.29, 1.28, and 7.31 microM, respectively. Compound 1 also shows slight cytotoxicity against HL-60 cells, with an IC 50 value of 9.71 microM. Compounds 4 and 5 display significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 microM and 10.65, 5.33, and 10.65 microM, respectively. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/18505285/Cytotoxic_alkaloids_and_antibiotic_nordammarane_triterpenoids_from_the_marine_derived_fungus_Aspergillus_sydowi_ L2 - https://doi.org/10.1021/np700737g DB - PRIME DP - Unbound Medicine ER -