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High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus.
Clin Endocrinol (Oxf). 2009 Feb; 70(2):221-6.CE

Abstract

OBJECTIVES

In type 2 diabetes mellitus, circulating C-reactive protein (CRP) is increased, whereas the high density lipoprotein (HDL)-associated, anti-oxidative and anti-inflammatory enzyme, paraoxonase-I, is decreased. Both high CRP and low paraoxonase-I activity may predict cardiovascular disease. It is unknown whether lower paraoxonase-I activity contributes to higher CRP levels in diabetes. In type 2 diabetic and control subjects, we determined the relationship of CRP with paraoxonase-I when taking account of plasma levels of pro- and anti-inflammatory adipokines.

DESIGN AND PATIENTS

In 81 type 2 diabetic patients and 89 control subjects, plasma high-sensitive CRP, serum paraoxonase-I activity (arylesterase activity, assayed as the rate of hydrolysis of phenyl acetate into phenol), plasma leptin, adiponectin, resistin and lipids were determined.

RESULTS

Body mass index (BMI), waist, insulin resistance, triglycerides, CRP, leptin and resistin levels were higher (P < 0.05 to P < 0.001), whereas HDL cholesterol, paraoxonase-I activity and adiponectin levels were lower (P = 0.02 to P < 0.001) in diabetic compared to control subjects. Multiple linear regression analysis demonstrated that, after controlling for age and gender, CRP was inversely related to paraoxonase-I activity (beta = -0.15, P = 0.028) and adiponectin (beta = -0.18, P = 0.009), and positively to leptin (beta = 0.33, P < 0.001) and BMI (beta = 0.22, P = 0.007), independently of the diabetic state (or of fasting glucose or HbA1c), insulin resistance and lipids (P > 0.20 for all).

CONCLUSIONS

Low paraoxonase-I activity is related to higher CRP, independently of adipokines, as well as of obesity and lipids. Low paraoxonase-I activity in type 2 diabetes mellitus may contribute to increased cardiovascular risk via an effect on enhanced systemic low-grade inflammation.

Authors+Show Affiliations

Department of Endocrinology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. r.p.f.dullaart@int.umcg.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18505467

Citation

Dullaart, Robin P F., et al. "High Plasma C-reactive Protein (CRP) Is Related to Low paraoxonase-I (PON-I) Activity Independently of High Leptin and Low Adiponectin in Type 2 Diabetes Mellitus." Clinical Endocrinology, vol. 70, no. 2, 2009, pp. 221-6.
Dullaart RP, de Vries R, Sluiter WJ, et al. High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus. Clin Endocrinol (Oxf). 2009;70(2):221-6.
Dullaart, R. P., de Vries, R., Sluiter, W. J., & Voorbij, H. A. (2009). High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus. Clinical Endocrinology, 70(2), 221-6. https://doi.org/10.1111/j.1365-2265.2008.03306.x
Dullaart RP, et al. High Plasma C-reactive Protein (CRP) Is Related to Low paraoxonase-I (PON-I) Activity Independently of High Leptin and Low Adiponectin in Type 2 Diabetes Mellitus. Clin Endocrinol (Oxf). 2009;70(2):221-6. PubMed PMID: 18505467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus. AU - Dullaart,Robin P F, AU - de Vries,Rindert, AU - Sluiter,Wim J, AU - Voorbij,Hieronymus A M, PY - 2008/5/29/pubmed PY - 2009/8/19/medline PY - 2008/5/29/entrez SP - 221 EP - 6 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 70 IS - 2 N2 - OBJECTIVES: In type 2 diabetes mellitus, circulating C-reactive protein (CRP) is increased, whereas the high density lipoprotein (HDL)-associated, anti-oxidative and anti-inflammatory enzyme, paraoxonase-I, is decreased. Both high CRP and low paraoxonase-I activity may predict cardiovascular disease. It is unknown whether lower paraoxonase-I activity contributes to higher CRP levels in diabetes. In type 2 diabetic and control subjects, we determined the relationship of CRP with paraoxonase-I when taking account of plasma levels of pro- and anti-inflammatory adipokines. DESIGN AND PATIENTS: In 81 type 2 diabetic patients and 89 control subjects, plasma high-sensitive CRP, serum paraoxonase-I activity (arylesterase activity, assayed as the rate of hydrolysis of phenyl acetate into phenol), plasma leptin, adiponectin, resistin and lipids were determined. RESULTS: Body mass index (BMI), waist, insulin resistance, triglycerides, CRP, leptin and resistin levels were higher (P < 0.05 to P < 0.001), whereas HDL cholesterol, paraoxonase-I activity and adiponectin levels were lower (P = 0.02 to P < 0.001) in diabetic compared to control subjects. Multiple linear regression analysis demonstrated that, after controlling for age and gender, CRP was inversely related to paraoxonase-I activity (beta = -0.15, P = 0.028) and adiponectin (beta = -0.18, P = 0.009), and positively to leptin (beta = 0.33, P < 0.001) and BMI (beta = 0.22, P = 0.007), independently of the diabetic state (or of fasting glucose or HbA1c), insulin resistance and lipids (P > 0.20 for all). CONCLUSIONS: Low paraoxonase-I activity is related to higher CRP, independently of adipokines, as well as of obesity and lipids. Low paraoxonase-I activity in type 2 diabetes mellitus may contribute to increased cardiovascular risk via an effect on enhanced systemic low-grade inflammation. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/18505467/High_plasma_C_reactive_protein__CRP__is_related_to_low_paraoxonase_I__PON_I__activity_independently_of_high_leptin_and_low_adiponectin_in_type_2_diabetes_mellitus_ L2 - https://doi.org/10.1111/j.1365-2265.2008.03306.x DB - PRIME DP - Unbound Medicine ER -