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Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS).
Clin Endocrinol (Oxf). 2008 Nov; 69(5):792-8.CE

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is a common female reproductive-age endocrine disease predominantly characterized by chronic anovulation, hyperandrogenism, insulin-resistance and low-grade inflammatory status. Exercise training (ET) favourably modulates cardiopulmonary function and insulin-sensitivity markers in PCOS women. The present study investigated the effects of ET on autonomic function and inflammatory pattern in PCOS women.

STUDY DESIGN

Prospective baseline uncontrolled clinical study.

METHODS

One-hundred and eighty five PCOS women referred to our department were screened for the inclusion into the study protocol from March 2004 to July 2007. One-hundred and twenty four PCOS women met the criteria for the inclusion into the study protocol and were subdivided into two groups each composed of 62 patients: PCOS-T (trained) group underwent 3-month ET program, whereas PCOS-UnT (untrained) group did not. At baseline and at 3-month follow-up, hormonal and metabolic profile, cardiopulmonary parameters, autonomic function (as expressed by heart rate recovery, HRR) and inflammatory pattern [as expressed by C-reactive protein (CRP) and white blood cells (WBCs) count] were evaluated.

RESULTS

PCOS-T showed a significant (P < 0.05) improvement in maximal oxygen consumption (VO(2max)) and in post-exercise HRR, and a significant (P < 0.001) decrease in CRP and WBCs; whereas no statistically significant changes of the same parameters were observed in PCOS-UnT. Multiple linear regression analysis showed that 3-month HRR is linearly related to the inclusion in training group (beta = 0.316, P < 0.001), VO(2max) (beta = 0.151, P = 0.032) and the ratio between glucose and insulin area under curve (AUC) (beta = 0.207, P = 0.003), and inversely related to body mass index (beta = -0.146, P = 0.046), insulin AUC (beta = -0.152, P = 0.032), CRP (beta = -0.165, P < 0.021), and WBCs count (beta = -0.175, P = 0.039).

CONCLUSIONS

Exercise training improves autonomic function and inflammatory pattern in PCOS women.

Authors+Show Affiliations

Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University of Naples, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

18505468

Citation

Giallauria, Francesco, et al. "Exercise Training Improves Autonomic Function and Inflammatory Pattern in Women With Polycystic Ovary Syndrome (PCOS)." Clinical Endocrinology, vol. 69, no. 5, 2008, pp. 792-8.
Giallauria F, Palomba S, Maresca L, et al. Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf). 2008;69(5):792-8.
Giallauria, F., Palomba, S., Maresca, L., Vuolo, L., Tafuri, D., Lombardi, G., Colao, A., Vigorito, C., & Francesco, O. (2008). Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS). Clinical Endocrinology, 69(5), 792-8. https://doi.org/10.1111/j.1365-2265.2008.03305.x
Giallauria F, et al. Exercise Training Improves Autonomic Function and Inflammatory Pattern in Women With Polycystic Ovary Syndrome (PCOS). Clin Endocrinol (Oxf). 2008;69(5):792-8. PubMed PMID: 18505468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS). AU - Giallauria,Francesco, AU - Palomba,Stefano, AU - Maresca,Luigi, AU - Vuolo,Laura, AU - Tafuri,Domenico, AU - Lombardi,Gaetano, AU - Colao,Annamaria, AU - Vigorito,Carlo, AU - Francesco,Orio, Y1 - 2008/05/23/ PY - 2008/5/29/pubmed PY - 2009/8/21/medline PY - 2008/5/29/entrez SP - 792 EP - 8 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 69 IS - 5 N2 - BACKGROUND: Polycystic ovary syndrome (PCOS) is a common female reproductive-age endocrine disease predominantly characterized by chronic anovulation, hyperandrogenism, insulin-resistance and low-grade inflammatory status. Exercise training (ET) favourably modulates cardiopulmonary function and insulin-sensitivity markers in PCOS women. The present study investigated the effects of ET on autonomic function and inflammatory pattern in PCOS women. STUDY DESIGN: Prospective baseline uncontrolled clinical study. METHODS: One-hundred and eighty five PCOS women referred to our department were screened for the inclusion into the study protocol from March 2004 to July 2007. One-hundred and twenty four PCOS women met the criteria for the inclusion into the study protocol and were subdivided into two groups each composed of 62 patients: PCOS-T (trained) group underwent 3-month ET program, whereas PCOS-UnT (untrained) group did not. At baseline and at 3-month follow-up, hormonal and metabolic profile, cardiopulmonary parameters, autonomic function (as expressed by heart rate recovery, HRR) and inflammatory pattern [as expressed by C-reactive protein (CRP) and white blood cells (WBCs) count] were evaluated. RESULTS: PCOS-T showed a significant (P < 0.05) improvement in maximal oxygen consumption (VO(2max)) and in post-exercise HRR, and a significant (P < 0.001) decrease in CRP and WBCs; whereas no statistically significant changes of the same parameters were observed in PCOS-UnT. Multiple linear regression analysis showed that 3-month HRR is linearly related to the inclusion in training group (beta = 0.316, P < 0.001), VO(2max) (beta = 0.151, P = 0.032) and the ratio between glucose and insulin area under curve (AUC) (beta = 0.207, P = 0.003), and inversely related to body mass index (beta = -0.146, P = 0.046), insulin AUC (beta = -0.152, P = 0.032), CRP (beta = -0.165, P < 0.021), and WBCs count (beta = -0.175, P = 0.039). CONCLUSIONS: Exercise training improves autonomic function and inflammatory pattern in PCOS women. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/18505468/Exercise_training_improves_autonomic_function_and_inflammatory_pattern_in_women_with_polycystic_ovary_syndrome__PCOS__ DB - PRIME DP - Unbound Medicine ER -