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Inhibitory Effects of 150 Plant Extracts on Elastase Activity, and Their Anti-inflammatory Effects.

Abstract

The inhibitory effects of 150 medicinal plants on elastase activity were investigated. Among the 150 plants, six plant extracts (final concentration 1 mg/ml in methanol) exhibited more than 65% of inhibition of elastase activity. The inhibitory effects of six active plants, including Areca catechu (IC50, 42.4 mug/ml), Cinnamonum cassia (IC50, 208.7 mug/ml), Myristica fragrans (IC50, 284.1 mug/ml), Curcuma longa (IC50, 398.4 mug/ml), Alpinia katsumadai (IC50, 465.7 mug/ml) and Dryopteris cassirrhizoma (IC50, 714.4 mug/ml) on the activity of human leukocyte elastase, hyaluronidase and lipid peroxidation were examined. In the lipid peroxidation assay, using the TBA method, three of the six plants, including Curcuma longa (IC50, 45.5 mug/ml), Areca catechu (IC50, 51.0 mug/ml) and Alpinia katsumadai (IC50, 116.3 mug/ml) exhibited more than 70% inhibition at the concentration of 1 mug/ml, but only one plant, Areca catechu (IC50, 563 mug/ml) showed high inhibitory effect on hyaluronidase activity. The results suggest that medicinal plants showing several biological activities may be potent inhibitors of the anti-ageing process in skin. This property might be useful for application in cosmetics.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, College of Natural Science, Chungbuk National University, Cheongju, 361-763, South Korea.

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    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18505532

    Citation

    Lee, K K., et al. "Inhibitory Effects of 150 Plant Extracts On Elastase Activity, and Their Anti-inflammatory Effects." International Journal of Cosmetic Science, vol. 21, no. 2, 1999, pp. 71-82.
    Lee KK, Kim JH, Cho JJ, et al. Inhibitory Effects of 150 Plant Extracts on Elastase Activity, and Their Anti-inflammatory Effects. Int J Cosmet Sci. 1999;21(2):71-82.
    Lee, K. K., Kim, J. H., Cho, J. J., & Choi, J. D. (1999). Inhibitory Effects of 150 Plant Extracts on Elastase Activity, and Their Anti-inflammatory Effects. International Journal of Cosmetic Science, 21(2), pp. 71-82. doi:10.1046/j.1467-2494.1999.181638.x.
    Lee KK, et al. Inhibitory Effects of 150 Plant Extracts On Elastase Activity, and Their Anti-inflammatory Effects. Int J Cosmet Sci. 1999;21(2):71-82. PubMed PMID: 18505532.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Inhibitory Effects of 150 Plant Extracts on Elastase Activity, and Their Anti-inflammatory Effects. AU - Lee,K K, AU - Kim,J H, AU - Cho,J J, AU - Choi,J D, PY - 2008/5/29/pubmed PY - 2008/5/29/medline PY - 2008/5/29/entrez SP - 71 EP - 82 JF - International journal of cosmetic science JO - Int J Cosmet Sci VL - 21 IS - 2 N2 - The inhibitory effects of 150 medicinal plants on elastase activity were investigated. Among the 150 plants, six plant extracts (final concentration 1 mg/ml in methanol) exhibited more than 65% of inhibition of elastase activity. The inhibitory effects of six active plants, including Areca catechu (IC50, 42.4 mug/ml), Cinnamonum cassia (IC50, 208.7 mug/ml), Myristica fragrans (IC50, 284.1 mug/ml), Curcuma longa (IC50, 398.4 mug/ml), Alpinia katsumadai (IC50, 465.7 mug/ml) and Dryopteris cassirrhizoma (IC50, 714.4 mug/ml) on the activity of human leukocyte elastase, hyaluronidase and lipid peroxidation were examined. In the lipid peroxidation assay, using the TBA method, three of the six plants, including Curcuma longa (IC50, 45.5 mug/ml), Areca catechu (IC50, 51.0 mug/ml) and Alpinia katsumadai (IC50, 116.3 mug/ml) exhibited more than 70% inhibition at the concentration of 1 mug/ml, but only one plant, Areca catechu (IC50, 563 mug/ml) showed high inhibitory effect on hyaluronidase activity. The results suggest that medicinal plants showing several biological activities may be potent inhibitors of the anti-ageing process in skin. This property might be useful for application in cosmetics. SN - 0142-5463 UR - https://www.unboundmedicine.com/medline/citation/18505532/Inhibitory_Effects_of_150_Plant_Extracts_on_Elastase_Activity_and_Their_Anti_inflammatory_Effects_ L2 - https://doi.org/10.1046/j.1467-2494.1999.181638.x DB - PRIME DP - Unbound Medicine ER -