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Industry-sponsored research.
Injury. 2008 Jun; 39(6):666-80.I

Abstract

Financial conflicts of interest are exceedingly common in biomedical research. Investigators with conflicts of interest are more likely to arrive at positive conclusions, perhaps as a result of biased study design, industry suppression of negative results, preferential funding by industry of projects that are likely to succeed, or biased interpretation of results on the part of investigators. Government and professional organisations have proposed guidelines for managing conflicts of interest, but in practice it is the policies of universities and medical journals that direct the actions of investigators. Academic researchers and the media have expressed concern about the influence of industry sponsorship on biomedical research, while industry is increasingly turning to private entities (such as contract research organisations) to conduct clinical trials. Research participants appear less concerned with conflicts of interest in biomedical research, perhaps due to a faith that such conflicts are being appropriately managed by institutions. After reviewing the literature, we provide recommendations for the ethical conduct of biomedical research in the presence of financial conflicts of interest.

Authors+Show Affiliations

Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. okike@post.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18508054

Citation

Okike, Kanu, et al. "Industry-sponsored Research." Injury, vol. 39, no. 6, 2008, pp. 666-80.
Okike K, Kocher MS, Mehlman CT, et al. Industry-sponsored research. Injury. 2008;39(6):666-80.
Okike, K., Kocher, M. S., Mehlman, C. T., & Bhandari, M. (2008). Industry-sponsored research. Injury, 39(6), 666-80. https://doi.org/10.1016/j.injury.2008.02.013
Okike K, et al. Industry-sponsored Research. Injury. 2008;39(6):666-80. PubMed PMID: 18508054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Industry-sponsored research. AU - Okike,Kanu, AU - Kocher,Mininder S, AU - Mehlman,Charles T, AU - Bhandari,Mohit, PY - 2007/09/25/received PY - 2008/02/06/accepted PY - 2008/5/30/pubmed PY - 2008/12/30/medline PY - 2008/5/30/entrez SP - 666 EP - 80 JF - Injury JO - Injury VL - 39 IS - 6 N2 - Financial conflicts of interest are exceedingly common in biomedical research. Investigators with conflicts of interest are more likely to arrive at positive conclusions, perhaps as a result of biased study design, industry suppression of negative results, preferential funding by industry of projects that are likely to succeed, or biased interpretation of results on the part of investigators. Government and professional organisations have proposed guidelines for managing conflicts of interest, but in practice it is the policies of universities and medical journals that direct the actions of investigators. Academic researchers and the media have expressed concern about the influence of industry sponsorship on biomedical research, while industry is increasingly turning to private entities (such as contract research organisations) to conduct clinical trials. Research participants appear less concerned with conflicts of interest in biomedical research, perhaps due to a faith that such conflicts are being appropriately managed by institutions. After reviewing the literature, we provide recommendations for the ethical conduct of biomedical research in the presence of financial conflicts of interest. SN - 0020-1383 UR - https://www.unboundmedicine.com/medline/citation/18508054/Industry_sponsored_research_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0020-1383(08)00114-9 DB - PRIME DP - Unbound Medicine ER -