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Development of a method for the determination of caffeine anhydrate in various designed intact tablets [correction of tables] by near-infrared spectroscopy: a comparison between reflectance and transmittance technique.
J Pharm Biomed Anal. 2008 Aug 05; 47(4-5):819-27.JP

Abstract

Using near-infrared (NIR) spectroscopy, an assay method which is not affected by such elements of tablet design as thickness, shape, embossing and scored line was developed. Tablets containing caffeine anhydrate were prepared by direct compression at various compression force levels using different shaped punches. NIR spectra were obtained from these intact tablets using the reflectance and transmittance techniques. A reference assay was performed by high-performance liquid chromatography (HPLC). Calibration models were generated by the partial least-squares (PLS) regression. Changes in the tablet thickness, shape, embossing and scored line caused NIR spectral changes in different ways, depending on the technique used. As a result, noticeable errors in drug content prediction occurred using calibration models generated according to the conventional method. On the other hand, when the various tablet design elements which caused the NIR spectral changes were included in the model, the prediction of the drug content in the tablets was scarcely affected by those elements when using either of the techniques. A comparison of these techniques resulted in higher predictability under the tablet design variations using the transmittance technique with preferable linearity and accuracy. This is probably attributed to the transmittance spectra which sensitively reflect the differences in tablet thickness or shape as a result of obtaining information inside the tablets.

Authors+Show Affiliations

Formulation Technology Research Laboratories, Daiichi-Sankyo Co. Ltd., 1-12-1 Shinomiya, Hiratsuka, Kanagawa 254-0014, Japan. ito.masatomo.id@daiichisankyo.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18508223

Citation

Ito, Masatomo, et al. "Development of a Method for the Determination of Caffeine Anhydrate in Various Designed Intact Tablets [correction of Tables] By Near-infrared Spectroscopy: a Comparison Between Reflectance and Transmittance Technique." Journal of Pharmaceutical and Biomedical Analysis, vol. 47, no. 4-5, 2008, pp. 819-27.
Ito M, Suzuki T, Yada S, et al. Development of a method for the determination of caffeine anhydrate in various designed intact tablets [correction of tables] by near-infrared spectroscopy: a comparison between reflectance and transmittance technique. J Pharm Biomed Anal. 2008;47(4-5):819-27.
Ito, M., Suzuki, T., Yada, S., Kusai, A., Nakagami, H., Yonemochi, E., & Terada, K. (2008). Development of a method for the determination of caffeine anhydrate in various designed intact tablets [correction of tables] by near-infrared spectroscopy: a comparison between reflectance and transmittance technique. Journal of Pharmaceutical and Biomedical Analysis, 47(4-5), 819-27. https://doi.org/10.1016/j.jpba.2008.03.033
Ito M, et al. Development of a Method for the Determination of Caffeine Anhydrate in Various Designed Intact Tablets [correction of Tables] By Near-infrared Spectroscopy: a Comparison Between Reflectance and Transmittance Technique. J Pharm Biomed Anal. 2008 Aug 5;47(4-5):819-27. PubMed PMID: 18508223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of a method for the determination of caffeine anhydrate in various designed intact tablets [correction of tables] by near-infrared spectroscopy: a comparison between reflectance and transmittance technique. AU - Ito,Masatomo, AU - Suzuki,Tatsuya, AU - Yada,Shuichi, AU - Kusai,Akira, AU - Nakagami,Hiroaki, AU - Yonemochi,Etsuo, AU - Terada,Katsuhide, Y1 - 2008/04/10/ PY - 2007/11/01/received PY - 2008/02/12/revised PY - 2008/03/28/accepted PY - 2008/5/30/pubmed PY - 2008/9/4/medline PY - 2008/5/30/entrez SP - 819 EP - 27 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 47 IS - 4-5 N2 - Using near-infrared (NIR) spectroscopy, an assay method which is not affected by such elements of tablet design as thickness, shape, embossing and scored line was developed. Tablets containing caffeine anhydrate were prepared by direct compression at various compression force levels using different shaped punches. NIR spectra were obtained from these intact tablets using the reflectance and transmittance techniques. A reference assay was performed by high-performance liquid chromatography (HPLC). Calibration models were generated by the partial least-squares (PLS) regression. Changes in the tablet thickness, shape, embossing and scored line caused NIR spectral changes in different ways, depending on the technique used. As a result, noticeable errors in drug content prediction occurred using calibration models generated according to the conventional method. On the other hand, when the various tablet design elements which caused the NIR spectral changes were included in the model, the prediction of the drug content in the tablets was scarcely affected by those elements when using either of the techniques. A comparison of these techniques resulted in higher predictability under the tablet design variations using the transmittance technique with preferable linearity and accuracy. This is probably attributed to the transmittance spectra which sensitively reflect the differences in tablet thickness or shape as a result of obtaining information inside the tablets. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/18508223/Development_of_a_method_for_the_determination_of_caffeine_anhydrate_in_various_designed_intact_tablets_[correction_of_tables]_by_near_infrared_spectroscopy:_a_comparison_between_reflectance_and_transmittance_technique_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(08)00205-7 DB - PRIME DP - Unbound Medicine ER -