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Association among metabolic syndrome, testosterone level and severity of erectile dysfunction.
Kaohsiung J Med Sci 2008; 24(5):240-7KJ

Abstract

The purpose of this study was to determine the influence of metabolic syndrome (MS) and serum testosterone in patients with erectile dysfunction (ED) and their possible association. A total of 103 men with ED were enrolled. The International Index of Erectile Function (IIEF) questionnaire was used to assess erectile condition. MS was defined according to the criteria formulated by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the International Diabetes Federation (IDF). The mean age of the study population was 57.5 +/- 10.7 years, with an average IIEF of 14.7 +/- 6.7. The age and prevalence of MS using the NCEP ATP III criteria, but not the IDF criteria, were significantly different between mild and moderate/severe ED patients (p = 0.031 and 0.009, respectively). The percentage of hypertension (78.6% vs. 36.2%; p < 0.001) and raised fasting glucose levels (46.4% vs. 19.1%; p = 0.004) were significantly higher in the moderate/severe ED group, and both differences remained significant in multivariate analysis (p = 0.001 and 0.042, respectively). In addition, serum testosterone levels were significantly lower in ED patients with MS (p = 0.002). In summary, the presence of MS is associated with more severe ED. Among the components of MS, elevated blood pressure and fasting blood glucose were independent risk factors. NCEP ATP III criteria seem to correlate better with the degree of ED than the IDF definition. Our results also indicate that MS is associated with a lower testosterone level in patients with ED.

Authors+Show Affiliations

Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18508421

Citation

Yeh, Hsin-Chih, et al. "Association Among Metabolic Syndrome, Testosterone Level and Severity of Erectile Dysfunction." The Kaohsiung Journal of Medical Sciences, vol. 24, no. 5, 2008, pp. 240-7.
Yeh HC, Wang CJ, Lee YC, et al. Association among metabolic syndrome, testosterone level and severity of erectile dysfunction. Kaohsiung J Med Sci. 2008;24(5):240-7.
Yeh, H. C., Wang, C. J., Lee, Y. C., Hsiao, H. L., Wu, W. J., Chou, Y. H., & Huang, C. H. (2008). Association among metabolic syndrome, testosterone level and severity of erectile dysfunction. The Kaohsiung Journal of Medical Sciences, 24(5), pp. 240-7. doi:10.1016/S1607-551X(08)70148-7.
Yeh HC, et al. Association Among Metabolic Syndrome, Testosterone Level and Severity of Erectile Dysfunction. Kaohsiung J Med Sci. 2008;24(5):240-7. PubMed PMID: 18508421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association among metabolic syndrome, testosterone level and severity of erectile dysfunction. AU - Yeh,Hsin-Chih, AU - Wang,Chii-Jye, AU - Lee,Yung-Chin, AU - Hsiao,Hsi-Lin, AU - Wu,Wen-Jeng, AU - Chou,Yii-Her, AU - Huang,Chun-Hsiung, PY - 2008/5/30/pubmed PY - 2008/9/3/medline PY - 2008/5/30/entrez SP - 240 EP - 7 JF - The Kaohsiung journal of medical sciences JO - Kaohsiung J. Med. Sci. VL - 24 IS - 5 N2 - The purpose of this study was to determine the influence of metabolic syndrome (MS) and serum testosterone in patients with erectile dysfunction (ED) and their possible association. A total of 103 men with ED were enrolled. The International Index of Erectile Function (IIEF) questionnaire was used to assess erectile condition. MS was defined according to the criteria formulated by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the International Diabetes Federation (IDF). The mean age of the study population was 57.5 +/- 10.7 years, with an average IIEF of 14.7 +/- 6.7. The age and prevalence of MS using the NCEP ATP III criteria, but not the IDF criteria, were significantly different between mild and moderate/severe ED patients (p = 0.031 and 0.009, respectively). The percentage of hypertension (78.6% vs. 36.2%; p < 0.001) and raised fasting glucose levels (46.4% vs. 19.1%; p = 0.004) were significantly higher in the moderate/severe ED group, and both differences remained significant in multivariate analysis (p = 0.001 and 0.042, respectively). In addition, serum testosterone levels were significantly lower in ED patients with MS (p = 0.002). In summary, the presence of MS is associated with more severe ED. Among the components of MS, elevated blood pressure and fasting blood glucose were independent risk factors. NCEP ATP III criteria seem to correlate better with the degree of ED than the IDF definition. Our results also indicate that MS is associated with a lower testosterone level in patients with ED. SN - 1607-551X UR - https://www.unboundmedicine.com/medline/citation/18508421/Association_among_metabolic_syndrome_testosterone_level_and_severity_of_erectile_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1607-551X(08)70148-7 DB - PRIME DP - Unbound Medicine ER -