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Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients.
Blood Purif. 2008; 26(4):371-8.BP

Abstract

BACKGROUND

Increased oxidative stress is associated with various complications in hemodialysis (HD) patients.

METHODS

We examined the effect of coenzyme Q10 (CoQ10) administration on the plasma oxidative products and antioxidant capacity in 36 HD patients for 6 months.

RESULTS

The advanced oxidation protein products (AOPP), malondialdehyde and the percentage of ubiquinone in total CoQ10 were significantly higher in HD patients than in healthy subjects before administration (0 month). Oxygen radical absorbing capacity (ORAC) and Trolox equivalent antioxidant capacity (TEAC), indicators of total antioxidant capacity, were also paradoxically higher in the HD patients at 0 month. AOPP and the percentage of ubiquinone significantly decreased during CoQ10 administration, but increased again after the discontinuation. ORAC and TEAC were also decreased during CoQ10 administration.

CONCLUSION

The CoQ10 administration was partially effective for suppressing the oxidative stress in HD patients. The unexpected decrease of ORAC and TEAC by CoQ10 seemed to be associated with a decreased oxidative stress.

Authors+Show Affiliations

Department of Clinical Nutrition, School of Food and Nutritional Sciences and COE Program in the 21st Century, University of Shizuoka, Shizuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18509244

Citation

Sakata, Tomoko, et al. "Coenzyme Q10 Administration Suppresses Both Oxidative and Antioxidative Markers in Hemodialysis Patients." Blood Purification, vol. 26, no. 4, 2008, pp. 371-8.
Sakata T, Furuya R, Shimazu T, et al. Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients. Blood Purif. 2008;26(4):371-8.
Sakata, T., Furuya, R., Shimazu, T., Odamaki, M., Ohkawa, S., & Kumagai, H. (2008). Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients. Blood Purification, 26(4), 371-8. https://doi.org/10.1159/000135605
Sakata T, et al. Coenzyme Q10 Administration Suppresses Both Oxidative and Antioxidative Markers in Hemodialysis Patients. Blood Purif. 2008;26(4):371-8. PubMed PMID: 18509244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients. AU - Sakata,Tomoko, AU - Furuya,Ryuichi, AU - Shimazu,Takako, AU - Odamaki,Mari, AU - Ohkawa,Sakae, AU - Kumagai,Hiromichi, Y1 - 2008/05/29/ PY - 2007/11/09/received PY - 2008/03/28/accepted PY - 2008/5/30/pubmed PY - 2008/11/19/medline PY - 2008/5/30/entrez SP - 371 EP - 8 JF - Blood purification JO - Blood Purif. VL - 26 IS - 4 N2 - BACKGROUND: Increased oxidative stress is associated with various complications in hemodialysis (HD) patients. METHODS: We examined the effect of coenzyme Q10 (CoQ10) administration on the plasma oxidative products and antioxidant capacity in 36 HD patients for 6 months. RESULTS: The advanced oxidation protein products (AOPP), malondialdehyde and the percentage of ubiquinone in total CoQ10 were significantly higher in HD patients than in healthy subjects before administration (0 month). Oxygen radical absorbing capacity (ORAC) and Trolox equivalent antioxidant capacity (TEAC), indicators of total antioxidant capacity, were also paradoxically higher in the HD patients at 0 month. AOPP and the percentage of ubiquinone significantly decreased during CoQ10 administration, but increased again after the discontinuation. ORAC and TEAC were also decreased during CoQ10 administration. CONCLUSION: The CoQ10 administration was partially effective for suppressing the oxidative stress in HD patients. The unexpected decrease of ORAC and TEAC by CoQ10 seemed to be associated with a decreased oxidative stress. SN - 1421-9735 UR - https://www.unboundmedicine.com/medline/citation/18509244/Coenzyme_Q10_administration_suppresses_both_oxidative_and_antioxidative_markers_in_hemodialysis_patients_ L2 - https://www.karger.com?DOI=10.1159/000135605 DB - PRIME DP - Unbound Medicine ER -