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Red blood cell microcytosis and hypochromia in the differential diagnosis of iron deficiency and beta-thalassaemia trait.
Int J Lab Hematol 2009; 31(5):528-34IJ

Abstract

Iron deficiency anaemia (IDA) and beta-thalassaemia are the most common causes of microcytic anaemia. Some indices have been defined to quickly discriminate this diseases based on red cell parameters obtained from automated blood cell analyzers, and can be effective for use as a preliminary screening tool to allow the reflex HbA(2) analysis, when a proper cut-off is chosen. Advia 2120 (Siemens Medical Solutions Diagnostics) directly measures volume and haemoglobin concentration of individual red cells, and quantifies the percentage of microcytic, normocytic, macrocytic, hypochromic, normochromic and hyperchromic red cells. Because of the inverse behaviour of the % microcytic and % hypochromic red cells in beta-thalassaemia trait and in IDA the ratio between these two values was computed and its discriminant efficiency assessed. The aim of the study was to assess the predictive value of the new index % microcytic/% hypochromic ratio in the differential diagnosis of beta-thalassaemia compared with Mentzer index, currently used in our Laboratory. Sensitivity, specificity and total efficiency of both indices were calculated for a set of 110 IDA patients and 150 beta-thalassaemia carriers. Discriminant efficiency was similar for both indices.

Authors+Show Affiliations

Haematology Laboratory, Hospital Galdakao - Usansolo, Galdakao 48960, Vizcaya, Spain. eloisa.urrechagaigartua@osakidetza.net

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18510574

Citation

Urrechaga, E. "Red Blood Cell Microcytosis and Hypochromia in the Differential Diagnosis of Iron Deficiency and Beta-thalassaemia Trait." International Journal of Laboratory Hematology, vol. 31, no. 5, 2009, pp. 528-34.
Urrechaga E. Red blood cell microcytosis and hypochromia in the differential diagnosis of iron deficiency and beta-thalassaemia trait. Int J Lab Hematol. 2009;31(5):528-34.
Urrechaga, E. (2009). Red blood cell microcytosis and hypochromia in the differential diagnosis of iron deficiency and beta-thalassaemia trait. International Journal of Laboratory Hematology, 31(5), pp. 528-34. doi:10.1111/j.1751-553X.2008.01073.x.
Urrechaga E. Red Blood Cell Microcytosis and Hypochromia in the Differential Diagnosis of Iron Deficiency and Beta-thalassaemia Trait. Int J Lab Hematol. 2009;31(5):528-34. PubMed PMID: 18510574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red blood cell microcytosis and hypochromia in the differential diagnosis of iron deficiency and beta-thalassaemia trait. A1 - Urrechaga,E, Y1 - 2008/05/27/ PY - 2008/5/31/pubmed PY - 2009/10/27/medline PY - 2008/5/31/entrez SP - 528 EP - 34 JF - International journal of laboratory hematology JO - Int J Lab Hematol VL - 31 IS - 5 N2 - Iron deficiency anaemia (IDA) and beta-thalassaemia are the most common causes of microcytic anaemia. Some indices have been defined to quickly discriminate this diseases based on red cell parameters obtained from automated blood cell analyzers, and can be effective for use as a preliminary screening tool to allow the reflex HbA(2) analysis, when a proper cut-off is chosen. Advia 2120 (Siemens Medical Solutions Diagnostics) directly measures volume and haemoglobin concentration of individual red cells, and quantifies the percentage of microcytic, normocytic, macrocytic, hypochromic, normochromic and hyperchromic red cells. Because of the inverse behaviour of the % microcytic and % hypochromic red cells in beta-thalassaemia trait and in IDA the ratio between these two values was computed and its discriminant efficiency assessed. The aim of the study was to assess the predictive value of the new index % microcytic/% hypochromic ratio in the differential diagnosis of beta-thalassaemia compared with Mentzer index, currently used in our Laboratory. Sensitivity, specificity and total efficiency of both indices were calculated for a set of 110 IDA patients and 150 beta-thalassaemia carriers. Discriminant efficiency was similar for both indices. SN - 1751-553X UR - https://www.unboundmedicine.com/medline/citation/18510574/Red_blood_cell_microcytosis_and_hypochromia_in_the_differential_diagnosis_of_iron_deficiency_and_beta_thalassaemia_trait_ L2 - https://doi.org/10.1111/j.1751-553X.2008.01073.x DB - PRIME DP - Unbound Medicine ER -