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The complex role of vitamin D in autoimmune diseases.
Scand J Immunol 2008; 68(3):261-9SJ

Abstract

Vitamin D, besides having well-known control functions of calcium and phosphorus metabolism, bone formation and mineralization, also has a role in the maintenance of immune-homeostasis. The immune-regulatory role of vitamin D affects both the innate and adaptive immune system contributing to the immune-tolerance of self-structures. Impaired vitamin D supply/regulation, amongst other factors, leads to the development of autoimmune processes in animal models of various autoimmune diseases. The administration of vitamin D in these animals leads to improvement of immune-mediated symptoms. Moreover, in human autoimmune diseases, such as multiple sclerosis, or rheumatoid arthritis the pathogenic role of vitamin D has been described. The review aims at describing the complex immune-regulatory role of vitamin D from the cellular level through autoimmune animal models and depicting the known contribution of vitamin D in the pathogenesis of human autoimmune diseases.

Authors+Show Affiliations

Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary. szodoray@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18510590

Citation

Szodoray, P, et al. "The Complex Role of Vitamin D in Autoimmune Diseases." Scandinavian Journal of Immunology, vol. 68, no. 3, 2008, pp. 261-9.
Szodoray P, Nakken B, Gaal J, et al. The complex role of vitamin D in autoimmune diseases. Scand J Immunol. 2008;68(3):261-9.
Szodoray, P., Nakken, B., Gaal, J., Jonsson, R., Szegedi, A., Zold, E., ... Bodolay, E. (2008). The complex role of vitamin D in autoimmune diseases. Scandinavian Journal of Immunology, 68(3), pp. 261-9. doi:10.1111/j.1365-3083.2008.02127.x.
Szodoray P, et al. The Complex Role of Vitamin D in Autoimmune Diseases. Scand J Immunol. 2008;68(3):261-9. PubMed PMID: 18510590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The complex role of vitamin D in autoimmune diseases. AU - Szodoray,P, AU - Nakken,B, AU - Gaal,J, AU - Jonsson,R, AU - Szegedi,A, AU - Zold,E, AU - Szegedi,G, AU - Brun,J G, AU - Gesztelyi,R, AU - Zeher,M, AU - Bodolay,E, Y1 - 2008/05/29/ PY - 2008/5/31/pubmed PY - 2008/10/8/medline PY - 2008/5/31/entrez SP - 261 EP - 9 JF - Scandinavian journal of immunology JO - Scand. J. Immunol. VL - 68 IS - 3 N2 - Vitamin D, besides having well-known control functions of calcium and phosphorus metabolism, bone formation and mineralization, also has a role in the maintenance of immune-homeostasis. The immune-regulatory role of vitamin D affects both the innate and adaptive immune system contributing to the immune-tolerance of self-structures. Impaired vitamin D supply/regulation, amongst other factors, leads to the development of autoimmune processes in animal models of various autoimmune diseases. The administration of vitamin D in these animals leads to improvement of immune-mediated symptoms. Moreover, in human autoimmune diseases, such as multiple sclerosis, or rheumatoid arthritis the pathogenic role of vitamin D has been described. The review aims at describing the complex immune-regulatory role of vitamin D from the cellular level through autoimmune animal models and depicting the known contribution of vitamin D in the pathogenesis of human autoimmune diseases. SN - 1365-3083 UR - https://www.unboundmedicine.com/medline/citation/18510590/The_complex_role_of_vitamin_D_in_autoimmune_diseases_ L2 - https://doi.org/10.1111/j.1365-3083.2008.02127.x DB - PRIME DP - Unbound Medicine ER -