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Predictors of serum ferritin and haemoglobin during pregnancy, in a malaria-endemic area of western Kenya.
Ann Trop Med Parasitol. 2008 Jun; 102(4):297-308.AT

Abstract

Between 2000 and 2004, a cross-sectional survey was conducted, as part of a prospective cohort study, among the women attending antenatal-care clinics in Bondo district, a malaria-endemic area of western Kenya. The aim was to assess the prevalence of iron deficiency and determine the predictors of haemoglobin and serum ferritin concentrations in the women who had a gestational age between 14 and 24 weeks. A standardized questionnaire was used to collect and store the relevant bio-data for the study. Haemoglobin and ferritin concentrations were evaluated, sickle-cell status was determined, and malarial parasitaemias were detected and evaluated, using blood samples collected at enrollment. Multiple regression analysis was then used to test for significant predictors of the haemoglobin and serum ferritin concentrations. Although 842 women were enrolled in the prospective cohort study, haemoglobin concentrations were evaluated for only 828 of them, serum ferritin levels for 621, and levels of parasitaemia for 812. The mean haemoglobin concentration recorded was 10.9 g/dl. Although 37.9% of the subjects had mild-moderate anaemia (7.0-10.5 g haemoglobin/dl), only 0.5% were severely anaemic (<7.0 g haemoglobin/dl). The geometric mean serum ferritin concentration recorded was 18.9 microg/litre, and 32.3% of the subjects evaluated had low serum concentrations of ferritin (<12 microg/litre). Among the parasitaemic primigravidae (but not the parasitaemic multigravidae), those found positive for sickle-cell trait had significantly lower haemoglobin concentrations than those found negative in a sickling test (P=0.01). Among the pregnant women of Bondo district, gravidity, malarial infection and sickle cell appear to be key predictors of haemoglobin concentration.

Authors+Show Affiliations

Division of Malaria Control, Ministry of Health, Nairobi, Kenya.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18510810

Citation

Alusala, D N., et al. "Predictors of Serum Ferritin and Haemoglobin During Pregnancy, in a Malaria-endemic Area of Western Kenya." Annals of Tropical Medicine and Parasitology, vol. 102, no. 4, 2008, pp. 297-308.
Alusala DN, Estambale BB, Magnussen P, et al. Predictors of serum ferritin and haemoglobin during pregnancy, in a malaria-endemic area of western Kenya. Ann Trop Med Parasitol. 2008;102(4):297-308.
Alusala, D. N., Estambale, B. B., Magnussen, P., Friis, H., Luoba, A. I., & Mwaniki, D. (2008). Predictors of serum ferritin and haemoglobin during pregnancy, in a malaria-endemic area of western Kenya. Annals of Tropical Medicine and Parasitology, 102(4), 297-308. https://doi.org/10.1179/136485908X278874
Alusala DN, et al. Predictors of Serum Ferritin and Haemoglobin During Pregnancy, in a Malaria-endemic Area of Western Kenya. Ann Trop Med Parasitol. 2008;102(4):297-308. PubMed PMID: 18510810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of serum ferritin and haemoglobin during pregnancy, in a malaria-endemic area of western Kenya. AU - Alusala,D N, AU - Estambale,B B A, AU - Magnussen,P, AU - Friis,H, AU - Luoba,A I, AU - Mwaniki,D, PY - 2008/5/31/pubmed PY - 2008/11/7/medline PY - 2008/5/31/entrez SP - 297 EP - 308 JF - Annals of tropical medicine and parasitology JO - Ann Trop Med Parasitol VL - 102 IS - 4 N2 - Between 2000 and 2004, a cross-sectional survey was conducted, as part of a prospective cohort study, among the women attending antenatal-care clinics in Bondo district, a malaria-endemic area of western Kenya. The aim was to assess the prevalence of iron deficiency and determine the predictors of haemoglobin and serum ferritin concentrations in the women who had a gestational age between 14 and 24 weeks. A standardized questionnaire was used to collect and store the relevant bio-data for the study. Haemoglobin and ferritin concentrations were evaluated, sickle-cell status was determined, and malarial parasitaemias were detected and evaluated, using blood samples collected at enrollment. Multiple regression analysis was then used to test for significant predictors of the haemoglobin and serum ferritin concentrations. Although 842 women were enrolled in the prospective cohort study, haemoglobin concentrations were evaluated for only 828 of them, serum ferritin levels for 621, and levels of parasitaemia for 812. The mean haemoglobin concentration recorded was 10.9 g/dl. Although 37.9% of the subjects had mild-moderate anaemia (7.0-10.5 g haemoglobin/dl), only 0.5% were severely anaemic (<7.0 g haemoglobin/dl). The geometric mean serum ferritin concentration recorded was 18.9 microg/litre, and 32.3% of the subjects evaluated had low serum concentrations of ferritin (<12 microg/litre). Among the parasitaemic primigravidae (but not the parasitaemic multigravidae), those found positive for sickle-cell trait had significantly lower haemoglobin concentrations than those found negative in a sickling test (P=0.01). Among the pregnant women of Bondo district, gravidity, malarial infection and sickle cell appear to be key predictors of haemoglobin concentration. SN - 0003-4983 UR - https://www.unboundmedicine.com/medline/citation/18510810/Predictors_of_serum_ferritin_and_haemoglobin_during_pregnancy_in_a_malaria_endemic_area_of_western_Kenya_ L2 - http://www.diseaseinfosearch.org/result/4415 DB - PRIME DP - Unbound Medicine ER -