Tags

Type your tag names separated by a space and hit enter

Reduced dose pre-exposure primary and booster intradermal rabies vaccination with a purified chick embryo cell vaccine (PCECV) is immunogenic and safe in adults.
Vaccine. 2008 Jun 25; 26(27-28):3438-42.V

Abstract

Pre-exposure vaccination of persons at risk with intradermally administered reduced dose cell culture rabies vaccines remains controversial in low-enzootic countries. In a prospective clinical trial of adult volunteers (N=25), we studied the immune response to purified chick embryo cell vaccine (PCECV) administered intradermally at a reduced dose (0.1 mL) in a three-dose schedule (0, 7 and 21 days). In 10 subjects, immunogenicity of intradermally administered one-dose booster vaccination with 0.1 mL PCECV was investigated. All participants were seroconverted 3 weeks after primary and 1 week after booster vaccination (antibody titre > or = 0.5 EU/mL, measured by enzyme linked immunosorbent assay). Local adverse events such as erythema and swelling were moderate and transitory. The intradermal vaccination route offers an efficacious and cost-reducing strategy to increase the accessibility of cell culture rabies vaccines.

Authors+Show Affiliations

Department of Infectious Diseases, C5-P, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18511158

Citation

Roukens, A H., et al. "Reduced Dose Pre-exposure Primary and Booster Intradermal Rabies Vaccination With a Purified Chick Embryo Cell Vaccine (PCECV) Is Immunogenic and Safe in Adults." Vaccine, vol. 26, no. 27-28, 2008, pp. 3438-42.
Roukens AH, Vossen AC, van Dissel JT, et al. Reduced dose pre-exposure primary and booster intradermal rabies vaccination with a purified chick embryo cell vaccine (PCECV) is immunogenic and safe in adults. Vaccine. 2008;26(27-28):3438-42.
Roukens, A. H., Vossen, A. C., van Dissel, J. T., & Visser, L. G. (2008). Reduced dose pre-exposure primary and booster intradermal rabies vaccination with a purified chick embryo cell vaccine (PCECV) is immunogenic and safe in adults. Vaccine, 26(27-28), 3438-42. https://doi.org/10.1016/j.vaccine.2008.04.033
Roukens AH, et al. Reduced Dose Pre-exposure Primary and Booster Intradermal Rabies Vaccination With a Purified Chick Embryo Cell Vaccine (PCECV) Is Immunogenic and Safe in Adults. Vaccine. 2008 Jun 25;26(27-28):3438-42. PubMed PMID: 18511158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced dose pre-exposure primary and booster intradermal rabies vaccination with a purified chick embryo cell vaccine (PCECV) is immunogenic and safe in adults. AU - Roukens,A H, AU - Vossen,A C, AU - van Dissel,J T, AU - Visser,L G, Y1 - 2008/05/05/ PY - 2007/12/10/received PY - 2008/04/07/revised PY - 2008/04/15/accepted PY - 2008/5/31/pubmed PY - 2008/9/10/medline PY - 2008/5/31/entrez SP - 3438 EP - 42 JF - Vaccine JO - Vaccine VL - 26 IS - 27-28 N2 - Pre-exposure vaccination of persons at risk with intradermally administered reduced dose cell culture rabies vaccines remains controversial in low-enzootic countries. In a prospective clinical trial of adult volunteers (N=25), we studied the immune response to purified chick embryo cell vaccine (PCECV) administered intradermally at a reduced dose (0.1 mL) in a three-dose schedule (0, 7 and 21 days). In 10 subjects, immunogenicity of intradermally administered one-dose booster vaccination with 0.1 mL PCECV was investigated. All participants were seroconverted 3 weeks after primary and 1 week after booster vaccination (antibody titre > or = 0.5 EU/mL, measured by enzyme linked immunosorbent assay). Local adverse events such as erythema and swelling were moderate and transitory. The intradermal vaccination route offers an efficacious and cost-reducing strategy to increase the accessibility of cell culture rabies vaccines. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/18511158/Reduced_dose_pre_exposure_primary_and_booster_intradermal_rabies_vaccination_with_a_purified_chick_embryo_cell_vaccine__PCECV__is_immunogenic_and_safe_in_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(08)00486-6 DB - PRIME DP - Unbound Medicine ER -