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Toxicity and gastric tolerance of essential oils from Cymbopogon citratus, Ocimum gratissimum and Ocimum basilicum in Wistar rats.
Food Chem Toxicol. 2008 Jul; 46(7):2493-7.FC

Abstract

Oils of Cymbopogon citratus, Ocimum gratissimum and Ocimum basilicum are widely used for their medicinal properties, and as food flavours and perfumes. Recently in a study in West Africa, these oils have been recommended to combat Fusarium verticillioides and subsequent fumonisin contamination in stored maize, but their toxicological profile was not investigated. The current study was undertaken to provide data on acute and subacute toxicity as well as on gastric tolerance of these oils in rat. For this purpose, the oils were given by gavage to Wistar rats for 14 consecutive days. The animals were observed daily for their general behaviour and survival, and their visceral organs such as stomach and liver were taken after sacrifice for histological analyses. A dose-dependent effect of the tested oils was observed during the study. Applied at doses generally higher than 1500 mg/kg body weight, the oils caused significant functional damages to stomach and liver of rat. Unlike the other oils, administration of O. gratissimum oil did not result in adverse effects in rat liver at the tested doses. The no observed adverse effect level (NOAEL) of the tested oils has been established. The three tested oils can be considered as safe to human when applied on stored maize at recommended concentrations.

Authors+Show Affiliations

Programme on Agricultural and Food Technology, National Institute of Agricultural Research of Benin, P.O. Box 128, Porto-Novo, Benin. lta@intnet.bjNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18511170

Citation

Fandohan, P, et al. "Toxicity and Gastric Tolerance of Essential Oils From Cymbopogon Citratus, Ocimum Gratissimum and Ocimum Basilicum in Wistar Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 7, 2008, pp. 2493-7.
Fandohan P, Gnonlonfin B, Laleye A, et al. Toxicity and gastric tolerance of essential oils from Cymbopogon citratus, Ocimum gratissimum and Ocimum basilicum in Wistar rats. Food Chem Toxicol. 2008;46(7):2493-7.
Fandohan, P., Gnonlonfin, B., Laleye, A., Gbenou, J. D., Darboux, R., & Moudachirou, M. (2008). Toxicity and gastric tolerance of essential oils from Cymbopogon citratus, Ocimum gratissimum and Ocimum basilicum in Wistar rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(7), 2493-7. https://doi.org/10.1016/j.fct.2008.04.006
Fandohan P, et al. Toxicity and Gastric Tolerance of Essential Oils From Cymbopogon Citratus, Ocimum Gratissimum and Ocimum Basilicum in Wistar Rats. Food Chem Toxicol. 2008;46(7):2493-7. PubMed PMID: 18511170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicity and gastric tolerance of essential oils from Cymbopogon citratus, Ocimum gratissimum and Ocimum basilicum in Wistar rats. AU - Fandohan,P, AU - Gnonlonfin,B, AU - Laleye,A, AU - Gbenou,J D, AU - Darboux,R, AU - Moudachirou,M, Y1 - 2008/04/13/ PY - 2007/08/20/received PY - 2008/04/04/revised PY - 2008/04/04/accepted PY - 2008/5/31/pubmed PY - 2008/8/6/medline PY - 2008/5/31/entrez SP - 2493 EP - 7 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 46 IS - 7 N2 - Oils of Cymbopogon citratus, Ocimum gratissimum and Ocimum basilicum are widely used for their medicinal properties, and as food flavours and perfumes. Recently in a study in West Africa, these oils have been recommended to combat Fusarium verticillioides and subsequent fumonisin contamination in stored maize, but their toxicological profile was not investigated. The current study was undertaken to provide data on acute and subacute toxicity as well as on gastric tolerance of these oils in rat. For this purpose, the oils were given by gavage to Wistar rats for 14 consecutive days. The animals were observed daily for their general behaviour and survival, and their visceral organs such as stomach and liver were taken after sacrifice for histological analyses. A dose-dependent effect of the tested oils was observed during the study. Applied at doses generally higher than 1500 mg/kg body weight, the oils caused significant functional damages to stomach and liver of rat. Unlike the other oils, administration of O. gratissimum oil did not result in adverse effects in rat liver at the tested doses. The no observed adverse effect level (NOAEL) of the tested oils has been established. The three tested oils can be considered as safe to human when applied on stored maize at recommended concentrations. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/18511170/Toxicity_and_gastric_tolerance_of_essential_oils_from_Cymbopogon_citratus_Ocimum_gratissimum_and_Ocimum_basilicum_in_Wistar_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00177-4 DB - PRIME DP - Unbound Medicine ER -