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Studies on the reduction of tensile strength of tablets after roll compaction/dry granulation.
Eur J Pharm Biopharm. 2008 Sep; 70(1):372-9.EJ

Abstract

Roll compaction/dry granulation is a widely used technique for granulation. A major drawback is the reduction of tablet tensile strength compared to other granulation methods. The purpose of this study was to determine the reasons for the partial loss in compactibility. Microcrystalline cellulose of different particle sizes was roll-compacted/dry-granulated. The granules were sieved to obtain two sieve cuts and then compressed into tablets. The particle-size distribution within the sieve cut was determined using image analysis. The specific surface area of sieve cut was obtained by nitrogen adsorption. Heckel equation was used to determine the change in compressibility. The work-hardening phenomenon was found to be caused by a combination of particle-size enlargement and hardening of material. Although particle size of granules was equal, the use of smaller particles as raw material resulted in tablets with higher tensile strength due to higher specific surface area. Both work-hardening and particle-size enlargement cause the partial loss in compactibility. The reduction in tensile strength could be compensated by producing smaller granules or using raw materials with small particle sizes.

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Authors+Show Affiliations

Herting MG
Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstrasse 1, Duesseldorf, Germany.
Kleinebudde P
No affiliation info available

MeSH

AdsorptionCelluloseExcipientsHardnessModels, ChemicalNitrogenParticle SizeSurface PropertiesTabletsTechnology, PharmaceuticalTensile Strength

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18511247

Citation

Herting, Michael G., and Peter Kleinebudde. "Studies On the Reduction of Tensile Strength of Tablets After Roll Compaction/dry Granulation." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 70, no. 1, 2008, pp. 372-9.
Herting MG, Kleinebudde P. Studies on the reduction of tensile strength of tablets after roll compaction/dry granulation. Eur J Pharm Biopharm. 2008;70(1):372-9.
Herting, M. G., & Kleinebudde, P. (2008). Studies on the reduction of tensile strength of tablets after roll compaction/dry granulation. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 70(1), 372-9. https://doi.org/10.1016/j.ejpb.2008.04.003
Herting MG, Kleinebudde P. Studies On the Reduction of Tensile Strength of Tablets After Roll Compaction/dry Granulation. Eur J Pharm Biopharm. 2008;70(1):372-9. PubMed PMID: 18511247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on the reduction of tensile strength of tablets after roll compaction/dry granulation. AU - Herting,Michael G, AU - Kleinebudde,Peter, Y1 - 2008/04/12/ PY - 2007/12/20/received PY - 2008/04/05/revised PY - 2008/04/08/accepted PY - 2008/5/31/pubmed PY - 2008/10/23/medline PY - 2008/5/31/entrez SP - 372 EP - 9 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 70 IS - 1 N2 - Roll compaction/dry granulation is a widely used technique for granulation. A major drawback is the reduction of tablet tensile strength compared to other granulation methods. The purpose of this study was to determine the reasons for the partial loss in compactibility. Microcrystalline cellulose of different particle sizes was roll-compacted/dry-granulated. The granules were sieved to obtain two sieve cuts and then compressed into tablets. The particle-size distribution within the sieve cut was determined using image analysis. The specific surface area of sieve cut was obtained by nitrogen adsorption. Heckel equation was used to determine the change in compressibility. The work-hardening phenomenon was found to be caused by a combination of particle-size enlargement and hardening of material. Although particle size of granules was equal, the use of smaller particles as raw material resulted in tablets with higher tensile strength due to higher specific surface area. Both work-hardening and particle-size enlargement cause the partial loss in compactibility. The reduction in tensile strength could be compensated by producing smaller granules or using raw materials with small particle sizes. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/18511247/Studies_on_the_reduction_of_tensile_strength_of_tablets_after_roll_compaction/dry_granulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(08)00144-6 DB - PRIME DP - Unbound Medicine ER -