Tags

Type your tag names separated by a space and hit enter

Influence of azithromycin and clarithromycin on macrolide susceptibility of viridans streptococci from the oral cavity of healthy volunteers.
Eur J Clin Microbiol Infect Dis. 2008 Nov; 27(11):1087-92.EJ

Abstract

Oral viridans streptococci are a reservoir of resistance genes for pathogens. Through prolonged exposure, long-acting macrolides (e.g., azithromycin) may induce the resistance of the commensals to macrolides more frequently than macrolides with a shorter half-life (e.g., clarithromycin). In a prospective, randomized, evaluator-blinded trial in healthy volunteers receiving standard courses of either azithromycin (n = 20) or clarithromycin (n = 20), we compared the susceptibility of oral viridans streptococci to macrolides over a period of 12 weeks. There was a significant temporal increase in the numbers of resistant isolates in both groups (p < 0.0005 at week 1). The proportion of macrolide-resistant isolates over time was significantly higher following azithromycin treatment (p = 0.0005), but returned to baseline values until week 12 in both groups. Temporal differential effects of azithromycin and clarithromycin on the induction of resistance were observed and need to be investigated regarding their effect on co-colonizing pathogens.

Authors+Show Affiliations

Institute for Microbiology and Hygiene, Charité-University Medicine Berlin, Campus Benjamin Franklin, Free University and Humboldt University Berlin, Berlin, Germany. martin.eisenblaetter@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18512087

Citation

Eisenblätter, M, et al. "Influence of Azithromycin and Clarithromycin On Macrolide Susceptibility of Viridans Streptococci From the Oral Cavity of Healthy Volunteers." European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, vol. 27, no. 11, 2008, pp. 1087-92.
Eisenblätter M, Klaus C, Pletz MW, et al. Influence of azithromycin and clarithromycin on macrolide susceptibility of viridans streptococci from the oral cavity of healthy volunteers. Eur J Clin Microbiol Infect Dis. 2008;27(11):1087-92.
Eisenblätter, M., Klaus, C., Pletz, M. W., Orawa, H., Hahn, H., Wagner, J., & Lode, H. (2008). Influence of azithromycin and clarithromycin on macrolide susceptibility of viridans streptococci from the oral cavity of healthy volunteers. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, 27(11), 1087-92. https://doi.org/10.1007/s10096-008-0547-x
Eisenblätter M, et al. Influence of Azithromycin and Clarithromycin On Macrolide Susceptibility of Viridans Streptococci From the Oral Cavity of Healthy Volunteers. Eur J Clin Microbiol Infect Dis. 2008;27(11):1087-92. PubMed PMID: 18512087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of azithromycin and clarithromycin on macrolide susceptibility of viridans streptococci from the oral cavity of healthy volunteers. AU - Eisenblätter,M, AU - Klaus,C, AU - Pletz,M W R, AU - Orawa,H, AU - Hahn,H, AU - Wagner,J, AU - Lode,H, Y1 - 2008/05/30/ PY - 2008/01/17/received PY - 2008/04/28/accepted PY - 2008/5/31/pubmed PY - 2009/2/14/medline PY - 2008/5/31/entrez SP - 1087 EP - 92 JF - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology JO - Eur J Clin Microbiol Infect Dis VL - 27 IS - 11 N2 - Oral viridans streptococci are a reservoir of resistance genes for pathogens. Through prolonged exposure, long-acting macrolides (e.g., azithromycin) may induce the resistance of the commensals to macrolides more frequently than macrolides with a shorter half-life (e.g., clarithromycin). In a prospective, randomized, evaluator-blinded trial in healthy volunteers receiving standard courses of either azithromycin (n = 20) or clarithromycin (n = 20), we compared the susceptibility of oral viridans streptococci to macrolides over a period of 12 weeks. There was a significant temporal increase in the numbers of resistant isolates in both groups (p < 0.0005 at week 1). The proportion of macrolide-resistant isolates over time was significantly higher following azithromycin treatment (p = 0.0005), but returned to baseline values until week 12 in both groups. Temporal differential effects of azithromycin and clarithromycin on the induction of resistance were observed and need to be investigated regarding their effect on co-colonizing pathogens. SN - 1435-4373 UR - https://www.unboundmedicine.com/medline/citation/18512087/Influence_of_azithromycin_and_clarithromycin_on_macrolide_susceptibility_of_viridans_streptococci_from_the_oral_cavity_of_healthy_volunteers_ L2 - https://dx.doi.org/10.1007/s10096-008-0547-x DB - PRIME DP - Unbound Medicine ER -