Prime

Type your tag names separated by a space and hit enter

The effects of scolicidal agent propolis on liver and biliary tree.

Abstract

BACKGROUND

This study was designed to examine the effects of propolis on the liver and biliary system when used as a scolicidal agent.

MATERIALS AND METHODS

Thirty Wistar-Albino rats were divided into two groups. Propolis and 0.9% saline (NaCl) were injected into the biliary tract of the rats. Three rats from control group and four rats from propolis group died within 5 days after the procedure. Blood samples of remaining 23 rats were obtained 1 week after and at the end of the experimental study for liver function tests. Six months after the procedure, retrograde and magnetic resonance cholangiography were performed and liver, common bile duct, and duodenum were excised en bloc for histopathological examination.

RESULTS

Liver function tests were slightly elevated 1 week after the procedure and were found to be normal at the end of the sixth month in both groups. No stricture in the biliary tree was found on the retrograde and magnetic resonance cholangiograms. The tissue samples of the propolis group showed no histomorphological difference from the control group.

CONCLUSIONS

Propolis may be used as a scolicidal agent even in the case of cystobiliary communication with no side effects on liver and biliary tree.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of General Surgery, Ankara Training and Research Hospital Ulucanlar, Ankara, Turkey. kemalkismet@yahoo.com

    , , , , , , , ,

    Source

    MeSH

    Animals
    Anti-Infective Agents
    Bile Ducts
    Cholangiopancreatography, Magnetic Resonance
    Disease Models, Animal
    Echinococcosis, Hepatic
    Female
    Liver
    Liver Function Tests
    Propolis
    Rats
    Rats, Wistar

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    18512108

    Citation

    TY - JOUR T1 - The effects of scolicidal agent propolis on liver and biliary tree. AU - Kismet,Kemal, AU - Kilicoglu,Sibel Serin, AU - Kilicoglu,Bulent, AU - Erel,Serap, AU - Gencay,Omur, AU - Sorkun,Kadriye, AU - Erdemli,Esra, AU - Akhan,Okan, AU - Akkus,Mehmet Ali, AU - Sayek,Iskender, Y1 - 2008/05/30/ PY - 2008/2/29/received PY - 2008/5/2/accepted PY - 2008/5/30/aheadofprint PY - 2008/5/31/pubmed PY - 2008/10/24/medline PY - 2008/5/31/entrez SP - 1406 EP - 11 JF - Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract JO - J. Gastrointest. Surg. VL - 12 IS - 8 N2 - BACKGROUND: This study was designed to examine the effects of propolis on the liver and biliary system when used as a scolicidal agent. MATERIALS AND METHODS: Thirty Wistar-Albino rats were divided into two groups. Propolis and 0.9% saline (NaCl) were injected into the biliary tract of the rats. Three rats from control group and four rats from propolis group died within 5 days after the procedure. Blood samples of remaining 23 rats were obtained 1 week after and at the end of the experimental study for liver function tests. Six months after the procedure, retrograde and magnetic resonance cholangiography were performed and liver, common bile duct, and duodenum were excised en bloc for histopathological examination. RESULTS: Liver function tests were slightly elevated 1 week after the procedure and were found to be normal at the end of the sixth month in both groups. No stricture in the biliary tree was found on the retrograde and magnetic resonance cholangiograms. The tissue samples of the propolis group showed no histomorphological difference from the control group. CONCLUSIONS: Propolis may be used as a scolicidal agent even in the case of cystobiliary communication with no side effects on liver and biliary tree. SN - 1873-4626 UR - https://www.unboundmedicine.com/medline/citation/18512108/full_citation/The_Effects_of_Scolicidal_Agent_Propolis_on_Liver_and_Biliary_Tree_ L2 - http://dx.doi.org/10.1007/s11605-008-0555-2 ER -