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Dietary risk factors for squamous cell carcinoma of the upper aerodigestive tract in central and eastern Europe.
Cancer Causes Control 2008; 19(10):1161-70CC

Abstract

OBJECTIVE

The incidence of squamous cell carcinoma of upper aerodigestive tract (UADT: oral cavity, pharynx, larynx, and esophagus) has been increasing in central and eastern European countries. We investigated the relationship between diet and UADT cancers in these high risk areas.

METHODS

We used data from hospital-based case-control study of 948 UADT cancer cases and 1,228 controls conducted in Romania, Hungary, Poland, Russia, Slovakia, and Czech Republic. Standardized questionnaire were used to collect information on 23 different food items, along with alcohol and tobacco consumptions. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the UADT cancers after adjusting for center, age, sex, tobacco & alcohol intake, and other food groups.

RESULTS

Consumption of dairy product was negatively associated with selected UADT cancers: larynx (OR: 0.38, CI: 0.23-0.62) and esophagus (OR: 0.55, CI: 0.33-0.93). While consumption of yellow/orange vegetables were inversely associated with oral/pharyngeal and laryngeal cancer (OR: 0.53, CI: 0.35-0.81 and OR: 0.62, CI: 0.38-1.00, respectively), preserved vegetable was positively associated with oral/pharyngeal and laryngeal cancer risk (p (trend) < 0.01 for both).

CONCLUSION

Specific dietary components may play a role in the development of UADT cancers in the high-risk region of central and eastern Europe.

Authors+Show Affiliations

Lifestyle, Environment and Cancer Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69008 Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18512121

Citation

Sapkota, A, et al. "Dietary Risk Factors for Squamous Cell Carcinoma of the Upper Aerodigestive Tract in Central and Eastern Europe." Cancer Causes & Control : CCC, vol. 19, no. 10, 2008, pp. 1161-70.
Sapkota A, Hsu CC, Zaridze D, et al. Dietary risk factors for squamous cell carcinoma of the upper aerodigestive tract in central and eastern Europe. Cancer Causes Control. 2008;19(10):1161-70.
Sapkota, A., Hsu, C. C., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Mates, D., ... Hashibe, M. (2008). Dietary risk factors for squamous cell carcinoma of the upper aerodigestive tract in central and eastern Europe. Cancer Causes & Control : CCC, 19(10), pp. 1161-70. doi:10.1007/s10552-008-9183-0.
Sapkota A, et al. Dietary Risk Factors for Squamous Cell Carcinoma of the Upper Aerodigestive Tract in Central and Eastern Europe. Cancer Causes Control. 2008;19(10):1161-70. PubMed PMID: 18512121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary risk factors for squamous cell carcinoma of the upper aerodigestive tract in central and eastern Europe. AU - Sapkota,A, AU - Hsu,C C, AU - Zaridze,D, AU - Shangina,O, AU - Szeszenia-Dabrowska,N, AU - Mates,D, AU - Fabiánová,E, AU - Rudnai,P, AU - Janout,V, AU - Holcatova,I, AU - Brennan,P, AU - Boffetta,P, AU - Hashibe,M, Y1 - 2008/05/30/ PY - 2007/05/10/received PY - 2008/05/13/accepted PY - 2008/5/31/pubmed PY - 2009/2/13/medline PY - 2008/5/31/entrez SP - 1161 EP - 70 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 19 IS - 10 N2 - OBJECTIVE: The incidence of squamous cell carcinoma of upper aerodigestive tract (UADT: oral cavity, pharynx, larynx, and esophagus) has been increasing in central and eastern European countries. We investigated the relationship between diet and UADT cancers in these high risk areas. METHODS: We used data from hospital-based case-control study of 948 UADT cancer cases and 1,228 controls conducted in Romania, Hungary, Poland, Russia, Slovakia, and Czech Republic. Standardized questionnaire were used to collect information on 23 different food items, along with alcohol and tobacco consumptions. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the UADT cancers after adjusting for center, age, sex, tobacco & alcohol intake, and other food groups. RESULTS: Consumption of dairy product was negatively associated with selected UADT cancers: larynx (OR: 0.38, CI: 0.23-0.62) and esophagus (OR: 0.55, CI: 0.33-0.93). While consumption of yellow/orange vegetables were inversely associated with oral/pharyngeal and laryngeal cancer (OR: 0.53, CI: 0.35-0.81 and OR: 0.62, CI: 0.38-1.00, respectively), preserved vegetable was positively associated with oral/pharyngeal and laryngeal cancer risk (p (trend) < 0.01 for both). CONCLUSION: Specific dietary components may play a role in the development of UADT cancers in the high-risk region of central and eastern Europe. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/18512121/Dietary_risk_factors_for_squamous_cell_carcinoma_of_the_upper_aerodigestive_tract_in_central_and_eastern_Europe_ L2 - https://doi.org/10.1007/s10552-008-9183-0 DB - PRIME DP - Unbound Medicine ER -