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REM behavior disorder, hallucinations and cognitive impairment in Parkinson's disease: a two-year follow up.
Mov Disord. 2008 Jul 30; 23(10):1441-5.MD

Abstract

In Parkinson's disease (PD) the presence of REM parasonnias as REM Behaviour Disorder (RBD) or vivid dreams/nightmares, is recognized as largely associated with hallucinations, even if the risk of the development of hallucinations seem not to depend on how long the REM parasomnias had been occurring. The aim of this study was to establish if RBDs occurring earlier than hallucinations in PD are predictive of cognitive impairment development. Three groups of PD patients: i) group 1, without RBD and without hallucinations; ii) group 2, with RBD but without hallucinations; iii) group 3, with RBD and hallucinations have been prospectively investigated at baseline and after two years throughout a clinical and neuropsychological evaluation. After two years, the group 1 continued to present normal neuropsychological tests and did not present either RBDs or hallucinations. In the group 2, the frontal impairment evidenced at baseline was confirmed; the onset of newly hallucinations was reported in a subgroup of 12 patients, who proved to be older, with a more severe executive impairment at baseline and with a more severe motor symptoms progression than those RBD patients who had not manifested hallucinations. The group 3, characterized at baseline by a more severe cognitive impairment presented, after two years, a cognitive worsening and a higher mortality rate. The longitudinal but at preliminary step investigation identified a PD subgroup of patients, in whom a common background disease profile, including the presence of RBD, could represent a "red flag" in developing further cognitive impairment.

Authors+Show Affiliations

Interdepartmental Research Centre for Parkinson's Disease (CRIMP), IRCCS C. Mondino Institute of Neurology, Pavia, Italy. elena.sinforiani@mondino.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18512749

Citation

Sinforiani, Elena, et al. "REM Behavior Disorder, Hallucinations and Cognitive Impairment in Parkinson's Disease: a Two-year Follow Up." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23, no. 10, 2008, pp. 1441-5.
Sinforiani E, Pacchetti C, Zangaglia R, et al. REM behavior disorder, hallucinations and cognitive impairment in Parkinson's disease: a two-year follow up. Mov Disord. 2008;23(10):1441-5.
Sinforiani, E., Pacchetti, C., Zangaglia, R., Pasotti, C., Manni, R., & Nappi, G. (2008). REM behavior disorder, hallucinations and cognitive impairment in Parkinson's disease: a two-year follow up. Movement Disorders : Official Journal of the Movement Disorder Society, 23(10), 1441-5. https://doi.org/10.1002/mds.22126
Sinforiani E, et al. REM Behavior Disorder, Hallucinations and Cognitive Impairment in Parkinson's Disease: a Two-year Follow Up. Mov Disord. 2008 Jul 30;23(10):1441-5. PubMed PMID: 18512749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - REM behavior disorder, hallucinations and cognitive impairment in Parkinson's disease: a two-year follow up. AU - Sinforiani,Elena, AU - Pacchetti,Claudio, AU - Zangaglia,Roberta, AU - Pasotti,Chiara, AU - Manni,Raffaele, AU - Nappi,Giuseppe, PY - 2008/6/3/pubmed PY - 2008/11/19/medline PY - 2008/6/3/entrez SP - 1441 EP - 5 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 23 IS - 10 N2 - In Parkinson's disease (PD) the presence of REM parasonnias as REM Behaviour Disorder (RBD) or vivid dreams/nightmares, is recognized as largely associated with hallucinations, even if the risk of the development of hallucinations seem not to depend on how long the REM parasomnias had been occurring. The aim of this study was to establish if RBDs occurring earlier than hallucinations in PD are predictive of cognitive impairment development. Three groups of PD patients: i) group 1, without RBD and without hallucinations; ii) group 2, with RBD but without hallucinations; iii) group 3, with RBD and hallucinations have been prospectively investigated at baseline and after two years throughout a clinical and neuropsychological evaluation. After two years, the group 1 continued to present normal neuropsychological tests and did not present either RBDs or hallucinations. In the group 2, the frontal impairment evidenced at baseline was confirmed; the onset of newly hallucinations was reported in a subgroup of 12 patients, who proved to be older, with a more severe executive impairment at baseline and with a more severe motor symptoms progression than those RBD patients who had not manifested hallucinations. The group 3, characterized at baseline by a more severe cognitive impairment presented, after two years, a cognitive worsening and a higher mortality rate. The longitudinal but at preliminary step investigation identified a PD subgroup of patients, in whom a common background disease profile, including the presence of RBD, could represent a "red flag" in developing further cognitive impairment. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/18512749/REM_behavior_disorder_hallucinations_and_cognitive_impairment_in_Parkinson's_disease:_a_two_year_follow_up_ L2 - https://doi.org/10.1002/mds.22126 DB - PRIME DP - Unbound Medicine ER -