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Age related mitochondrial degenerative disorders in humans.
Biotechnol J. 2008 Jun; 3(6):750-6.BJ

Abstract

Disorders caused by mitochondrial respiratory chain deficiency due to mutations in mitochondrial DNA have varied phenotypes but many involve neurological features often associated with cell loss within specific brain regions. These disorders, along with the increasing evidence of decline in mitochondrial function with ageing, have raised speculation that primary changes in mitochondria could have an important role in age-related neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). Evidence supporting a role for mitochondria in common neurodegenerative diseases comes from studies with the toxin MPP+ and familial PD, which has been shown to involve proteins such as DJ-1 and Pink1 (both of which are predicted to have a role in mitochondrial function and oxidative stress). Mutations within the mitochondrial genome have been shown to accumulate with age and in common neurodegenerative diseases. Mitochondrial DNA haplogroups have also been shown to be associated with certain neurodegenerative conditions. This review covers the primary mitochondrial diseases but also discuss the potential role of mitochondria and mitochondrial DNA mutations in mitochondrial and neurodegenerative diseases, in particular in PD and in AD.

Authors+Show Affiliations

Mitochondrial Research Group, Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18512864

Citation

Reeve, Amy K., et al. "Age Related Mitochondrial Degenerative Disorders in Humans." Biotechnology Journal, vol. 3, no. 6, 2008, pp. 750-6.
Reeve AK, Krishnan KJ, Turnbull DM. Age related mitochondrial degenerative disorders in humans. Biotechnol J. 2008;3(6):750-6.
Reeve, A. K., Krishnan, K. J., & Turnbull, D. M. (2008). Age related mitochondrial degenerative disorders in humans. Biotechnology Journal, 3(6), 750-6. https://doi.org/10.1002/biot.200800066
Reeve AK, Krishnan KJ, Turnbull DM. Age Related Mitochondrial Degenerative Disorders in Humans. Biotechnol J. 2008;3(6):750-6. PubMed PMID: 18512864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age related mitochondrial degenerative disorders in humans. AU - Reeve,Amy K, AU - Krishnan,Kim J, AU - Turnbull,Doug M, PY - 2008/6/3/pubmed PY - 2008/7/22/medline PY - 2008/6/3/entrez SP - 750 EP - 6 JF - Biotechnology journal JO - Biotechnol J VL - 3 IS - 6 N2 - Disorders caused by mitochondrial respiratory chain deficiency due to mutations in mitochondrial DNA have varied phenotypes but many involve neurological features often associated with cell loss within specific brain regions. These disorders, along with the increasing evidence of decline in mitochondrial function with ageing, have raised speculation that primary changes in mitochondria could have an important role in age-related neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). Evidence supporting a role for mitochondria in common neurodegenerative diseases comes from studies with the toxin MPP+ and familial PD, which has been shown to involve proteins such as DJ-1 and Pink1 (both of which are predicted to have a role in mitochondrial function and oxidative stress). Mutations within the mitochondrial genome have been shown to accumulate with age and in common neurodegenerative diseases. Mitochondrial DNA haplogroups have also been shown to be associated with certain neurodegenerative conditions. This review covers the primary mitochondrial diseases but also discuss the potential role of mitochondria and mitochondrial DNA mutations in mitochondrial and neurodegenerative diseases, in particular in PD and in AD. SN - 1860-7314 UR - https://www.unboundmedicine.com/medline/citation/18512864/Age_related_mitochondrial_degenerative_disorders_in_humans_ L2 - https://doi.org/10.1002/biot.200800066 DB - PRIME DP - Unbound Medicine ER -