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High-sensitivity C-reactive protein: a predicative marker in severe asthma.
Respirology. 2008 Sep; 13(5):664-9.R

Abstract

BACKGROUND AND OBJECTIVE

Serum levels of high-sensitivity CRP (hs-CRP) are associated with asthma but the relationship between higher levels of hs-CRP and the degree of asthma severity remains unclear. This study investigated whether hs-CRP is associated with asthma severity as well as with other clinical indices of asthma activity (pulmonary function, total serum IgE, and peripheral blood eosinophil counts).

METHODS

Levels of hs-CRP and clinical indices of asthma were determined among 177 control subjects and 281 asthmatic patients (84 intermittent, 30 mild, 63 moderate and 104 severe).

RESULTS

The level of hs-CRP was examined as both a continuous variable and by quartiles (<0.23, 0.23-0.51, 0.51-1.42 and >or=1.42 mg/L) in the five groups. Compared with the first quartile of hs-CRP, patients with higher levels were at increased risk of severe asthma independently of other clinical indices (adjusted OR 3.49, 95% CI: 1.51-8.12 for the third quartile; adjusted OR 6.46, 95% CI: 2.85-16.62 for fourth quartile, respectively).

CONCLUSIONS

These findings suggest that hs-CRP might be a sensitive marker for severe asthma.

Authors+Show Affiliations

Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18513241

Citation

Qian, Fen-Hong, et al. "High-sensitivity C-reactive Protein: a Predicative Marker in Severe Asthma." Respirology (Carlton, Vic.), vol. 13, no. 5, 2008, pp. 664-9.
Qian FH, Zhang Q, Zhou LF, et al. High-sensitivity C-reactive protein: a predicative marker in severe asthma. Respirology. 2008;13(5):664-9.
Qian, F. H., Zhang, Q., Zhou, L. F., Liu, H., Huang, M., Zhang, X. L., & Yin, K. S. (2008). High-sensitivity C-reactive protein: a predicative marker in severe asthma. Respirology (Carlton, Vic.), 13(5), 664-9. https://doi.org/10.1111/j.1440-1843.2008.01314.x
Qian FH, et al. High-sensitivity C-reactive Protein: a Predicative Marker in Severe Asthma. Respirology. 2008;13(5):664-9. PubMed PMID: 18513241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-sensitivity C-reactive protein: a predicative marker in severe asthma. AU - Qian,Fen-Hong, AU - Zhang,Qian, AU - Zhou,Lin-Fu, AU - Liu,Hua, AU - Huang,Mao, AU - Zhang,Xi-Long, AU - Yin,Kai-Sheng, Y1 - 2008/05/29/ PY - 2008/6/3/pubmed PY - 2008/12/17/medline PY - 2008/6/3/entrez SP - 664 EP - 9 JF - Respirology (Carlton, Vic.) JO - Respirology VL - 13 IS - 5 N2 - BACKGROUND AND OBJECTIVE: Serum levels of high-sensitivity CRP (hs-CRP) are associated with asthma but the relationship between higher levels of hs-CRP and the degree of asthma severity remains unclear. This study investigated whether hs-CRP is associated with asthma severity as well as with other clinical indices of asthma activity (pulmonary function, total serum IgE, and peripheral blood eosinophil counts). METHODS: Levels of hs-CRP and clinical indices of asthma were determined among 177 control subjects and 281 asthmatic patients (84 intermittent, 30 mild, 63 moderate and 104 severe). RESULTS: The level of hs-CRP was examined as both a continuous variable and by quartiles (<0.23, 0.23-0.51, 0.51-1.42 and >or=1.42 mg/L) in the five groups. Compared with the first quartile of hs-CRP, patients with higher levels were at increased risk of severe asthma independently of other clinical indices (adjusted OR 3.49, 95% CI: 1.51-8.12 for the third quartile; adjusted OR 6.46, 95% CI: 2.85-16.62 for fourth quartile, respectively). CONCLUSIONS: These findings suggest that hs-CRP might be a sensitive marker for severe asthma. SN - 1440-1843 UR - https://www.unboundmedicine.com/medline/citation/18513241/High_sensitivity_C_reactive_protein:_a_predicative_marker_in_severe_asthma_ L2 - https://doi.org/10.1111/j.1440-1843.2008.01314.x DB - PRIME DP - Unbound Medicine ER -