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Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus: The Hoorn Study.
Diabet Med 2008; 25(7):843-9DM

Abstract

OBJECTIVE

To study the prevalence and risk factors of depressive symptoms, comparing subjects with normal glucose metabolism (NGM), impaired glucose metabolism (IGM) or Type 2 diabetes mellitus (DM2).

RESEARCH DESIGN AND METHODS

Cross-sectional data from a population-based cohort study conducted among 550 residents (276 men and 274 women) of the Hoorn region, the Netherlands. Levels of depressive symptoms were measured using the Centre for Epidemiologic Studies Depression Scale (CES-D score > or = 16). Glucose metabolism status was determined by means of fasting and post-load glucose levels.

RESULTS

The prevalence of depressive symptoms in men with NGM, IGM and DM2 was 7.7, 7.0 and 15.0% (P = 0.19) and for women 7.7, 23.1 and 19.7% (P < 0.01), respectively. Depression was significantly more common in women with IGM [odds ratio (OR) = 3.60, 95% confidence interval (CI) = 1.57 to 8.28] and women with DM2 (OR = 3.18, 95% CI = 1.31 to 7.74). In men, depression was not associated with IGM (OR = 0.90, 95% CI = 0.32 to 2.57) and non-significantly more common in DM2 (OR = 2.04, 95% CI = 0.75 to 5.49). Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms reduced the strength of these associations.

CONCLUSIONS

Depressive symptoms are more common in women with IGM, but not men. Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms partially attenuated these associations, suggesting that these variables could be intermediate factors.

Authors+Show Affiliations

Institute of Health Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, the Netherlands.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18513303

Citation

Adriaanse, M C., et al. "Symptoms of Depression in People With Impaired Glucose Metabolism or Type 2 Diabetes Mellitus: the Hoorn Study." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 25, no. 7, 2008, pp. 843-9.
Adriaanse MC, Dekker JM, Heine RJ, et al. Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus: The Hoorn Study. Diabet Med. 2008;25(7):843-9.
Adriaanse, M. C., Dekker, J. M., Heine, R. J., Snoek, F. J., Beekman, A. J., Stehouwer, C. D., ... Pouwer, F. (2008). Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus: The Hoorn Study. Diabetic Medicine : a Journal of the British Diabetic Association, 25(7), pp. 843-9. doi:10.1111/j.1464-5491.2008.02464.x.
Adriaanse MC, et al. Symptoms of Depression in People With Impaired Glucose Metabolism or Type 2 Diabetes Mellitus: the Hoorn Study. Diabet Med. 2008;25(7):843-9. PubMed PMID: 18513303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus: The Hoorn Study. AU - Adriaanse,M C, AU - Dekker,J M, AU - Heine,R J, AU - Snoek,F J, AU - Beekman,A J, AU - Stehouwer,C D, AU - Bouter,L M, AU - Nijpels,G, AU - Pouwer,F, PY - 2008/6/3/pubmed PY - 2008/8/21/medline PY - 2008/6/3/entrez SP - 843 EP - 9 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 25 IS - 7 N2 - OBJECTIVE: To study the prevalence and risk factors of depressive symptoms, comparing subjects with normal glucose metabolism (NGM), impaired glucose metabolism (IGM) or Type 2 diabetes mellitus (DM2). RESEARCH DESIGN AND METHODS: Cross-sectional data from a population-based cohort study conducted among 550 residents (276 men and 274 women) of the Hoorn region, the Netherlands. Levels of depressive symptoms were measured using the Centre for Epidemiologic Studies Depression Scale (CES-D score > or = 16). Glucose metabolism status was determined by means of fasting and post-load glucose levels. RESULTS: The prevalence of depressive symptoms in men with NGM, IGM and DM2 was 7.7, 7.0 and 15.0% (P = 0.19) and for women 7.7, 23.1 and 19.7% (P < 0.01), respectively. Depression was significantly more common in women with IGM [odds ratio (OR) = 3.60, 95% confidence interval (CI) = 1.57 to 8.28] and women with DM2 (OR = 3.18, 95% CI = 1.31 to 7.74). In men, depression was not associated with IGM (OR = 0.90, 95% CI = 0.32 to 2.57) and non-significantly more common in DM2 (OR = 2.04, 95% CI = 0.75 to 5.49). Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms reduced the strength of these associations. CONCLUSIONS: Depressive symptoms are more common in women with IGM, but not men. Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms partially attenuated these associations, suggesting that these variables could be intermediate factors. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/18513303/Symptoms_of_depression_in_people_with_impaired_glucose_metabolism_or_Type_2_diabetes_mellitus:_The_Hoorn_Study_ L2 - https://doi.org/10.1111/j.1464-5491.2008.02464.x DB - PRIME DP - Unbound Medicine ER -