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Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives.

Abstract

We investigated the effect of polymorphic variants of c.1298A>C (Glu429Ala) and c.677C>T (Ala222Val) in methylenetetrahydrofolate (MTHFR) gene on the total homocysteine (tHcy), folate and B12 levels in patients with bipolar disorder, first-degree relatives of patients, and controls. The c.677C>T and c.1298A>C polymorphisms in MTHFR were determined by polymerase chain reaction-restriction fragment length polymorphism in 197 bipolar patients, 278 relatives and 238 controls. tHcy and folate and vitamin B12 levels were measured by Fluorescence Polarization Immunoassay and Electrochemiluminescence, respectively. The tHcy was significantly increased in patients and relatives. In contrast, folate and B12 were significantly lower in patients and relatives. Gender was not considered as a significant determinant in the multivariate analysis. Genotypes of c.1298A>C and c.677C>T were correlated with tHcy, folate and B12. Patients and relatives carrying TT and/or AA and AC genotypes had elevated tHcy and reduced folate and B12 levels. High tHcy but low folate and vitamin B12 levels may be a risk factor for development of bipolar disorder.

Authors+Show Affiliations

Department of Biochemistry, Eyup State Hospital, Istanbul, Turkey.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18513846

Citation

Ozbek, Zeynep, et al. "Effect of the Methylenetetrahydrofolate Reductase Gene Polymorphisms On Homocysteine, Folate and Vitamin B12 in Patients With Bipolar Disorder and Relatives." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 32, no. 5, 2008, pp. 1331-7.
Ozbek Z, Kucukali CI, Ozkok E, et al. Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(5):1331-7.
Ozbek, Z., Kucukali, C. I., Ozkok, E., Orhan, N., Aydin, M., Kilic, G., ... Kara, I. (2008). Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives. Progress in Neuro-psychopharmacology & Biological Psychiatry, 32(5), pp. 1331-7. doi:10.1016/j.pnpbp.2008.04.016.
Ozbek Z, et al. Effect of the Methylenetetrahydrofolate Reductase Gene Polymorphisms On Homocysteine, Folate and Vitamin B12 in Patients With Bipolar Disorder and Relatives. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1331-7. PubMed PMID: 18513846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives. AU - Ozbek,Zeynep, AU - Kucukali,Cem Ismail, AU - Ozkok,Elif, AU - Orhan,Nurcan, AU - Aydin,Makbule, AU - Kilic,Gamze, AU - Sazci,Ali, AU - Kara,Ihsan, Y1 - 2008/05/02/ PY - 2007/11/09/received PY - 2008/04/24/revised PY - 2008/04/25/accepted PY - 2008/6/3/pubmed PY - 2008/11/6/medline PY - 2008/6/3/entrez SP - 1331 EP - 7 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 32 IS - 5 N2 - We investigated the effect of polymorphic variants of c.1298A>C (Glu429Ala) and c.677C>T (Ala222Val) in methylenetetrahydrofolate (MTHFR) gene on the total homocysteine (tHcy), folate and B12 levels in patients with bipolar disorder, first-degree relatives of patients, and controls. The c.677C>T and c.1298A>C polymorphisms in MTHFR were determined by polymerase chain reaction-restriction fragment length polymorphism in 197 bipolar patients, 278 relatives and 238 controls. tHcy and folate and vitamin B12 levels were measured by Fluorescence Polarization Immunoassay and Electrochemiluminescence, respectively. The tHcy was significantly increased in patients and relatives. In contrast, folate and B12 were significantly lower in patients and relatives. Gender was not considered as a significant determinant in the multivariate analysis. Genotypes of c.1298A>C and c.677C>T were correlated with tHcy, folate and B12. Patients and relatives carrying TT and/or AA and AC genotypes had elevated tHcy and reduced folate and B12 levels. High tHcy but low folate and vitamin B12 levels may be a risk factor for development of bipolar disorder. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/18513846/Effect_of_the_methylenetetrahydrofolate_reductase_gene_polymorphisms_on_homocysteine_folate_and_vitamin_B12_in_patients_with_bipolar_disorder_and_relatives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(08)00132-2 DB - PRIME DP - Unbound Medicine ER -