Tags

Type your tag names separated by a space and hit enter

Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata.
Bioresour Technol. 2008 Dec; 99(18):8783-7.BT

Abstract

In this study, the fruit essential oil of Cinnamomum insularimontanum was prepared by using water distillation. Followed by GC-MS analysis, the composition of fruit essential oil was characterized. The main constituents of essential oil were alpha-pinene (9.45%), camphene (1.70%), beta-pinene (4.30%), limonene (1.76%), citronellal (24.64%), citronellol (16.78%), and citral (35.89%). According to the results obtained from nitric oxide (NO) inhibitory activity assay, crude essential oil and its dominant compound (citral) presented the significant NO production inhibitory activity, IC(50) of crude essential oil and citral were 18.68 and 13.18microg/mL, respectively. Moreover, based on the results obtained from the protein expression assay, the expression of IKK, iNOS, and nuclear NF-kappaB was decreased and IkappaBalpha was increased in dose-dependent manners, it proved that the anti-inflammatory mechanism of citral was blocked via the NF-kappaB pathway, but it could not efficiently suppress the activity on COX-2. In addition, citral exhibited a potent anti-inflammatory activity in the assay of croton oil-induced mice ear edema, when the dosage was 0.1 and 0.3mg per ear, the inflammation would reduce to 22% and 83%, respectively. The results presented that the fruit essential oil of C. insularimontanum and/or citral may have a great potential to develop the anti-inflammatory medicine in the future.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Lin CT
Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan.
Chen CJ
No affiliation info available
Lin TY
No affiliation info available
Tung JC
No affiliation info available
Wang SY
No affiliation info available

MeSH

Acyclic MonoterpenesAnimalsAnti-Inflammatory AgentsCell LineCinnamomumEdemaFruitMiceMonoterpenesOils, VolatilePhytotherapy

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18513962

Citation

Lin, Chien-Tsong, et al. "Anti-inflammation Activity of Fruit Essential Oil From Cinnamomum Insularimontanum Hayata." Bioresource Technology, vol. 99, no. 18, 2008, pp. 8783-7.
Lin CT, Chen CJ, Lin TY, et al. Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata. Bioresour Technol. 2008;99(18):8783-7.
Lin, C. T., Chen, C. J., Lin, T. Y., Tung, J. C., & Wang, S. Y. (2008). Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata. Bioresource Technology, 99(18), 8783-7. https://doi.org/10.1016/j.biortech.2008.04.041
Lin CT, et al. Anti-inflammation Activity of Fruit Essential Oil From Cinnamomum Insularimontanum Hayata. Bioresour Technol. 2008;99(18):8783-7. PubMed PMID: 18513962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata. AU - Lin,Chien-Tsong, AU - Chen,Chi-Jung, AU - Lin,Ting-Yu, AU - Tung,Judia Chen, AU - Wang,Sheng-Yang, Y1 - 2008/05/29/ PY - 2008/01/13/received PY - 2008/04/15/revised PY - 2008/04/15/accepted PY - 2008/6/3/pubmed PY - 2008/12/17/medline PY - 2008/6/3/entrez SP - 8783 EP - 7 JF - Bioresource technology JO - Bioresour Technol VL - 99 IS - 18 N2 - In this study, the fruit essential oil of Cinnamomum insularimontanum was prepared by using water distillation. Followed by GC-MS analysis, the composition of fruit essential oil was characterized. The main constituents of essential oil were alpha-pinene (9.45%), camphene (1.70%), beta-pinene (4.30%), limonene (1.76%), citronellal (24.64%), citronellol (16.78%), and citral (35.89%). According to the results obtained from nitric oxide (NO) inhibitory activity assay, crude essential oil and its dominant compound (citral) presented the significant NO production inhibitory activity, IC(50) of crude essential oil and citral were 18.68 and 13.18microg/mL, respectively. Moreover, based on the results obtained from the protein expression assay, the expression of IKK, iNOS, and nuclear NF-kappaB was decreased and IkappaBalpha was increased in dose-dependent manners, it proved that the anti-inflammatory mechanism of citral was blocked via the NF-kappaB pathway, but it could not efficiently suppress the activity on COX-2. In addition, citral exhibited a potent anti-inflammatory activity in the assay of croton oil-induced mice ear edema, when the dosage was 0.1 and 0.3mg per ear, the inflammation would reduce to 22% and 83%, respectively. The results presented that the fruit essential oil of C. insularimontanum and/or citral may have a great potential to develop the anti-inflammatory medicine in the future. SN - 0960-8524 UR - https://www.unboundmedicine.com/medline/citation/18513962/Anti_inflammation_activity_of_fruit_essential_oil_from_Cinnamomum_insularimontanum_Hayata_ DB - PRIME DP - Unbound Medicine ER -