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Hippocampal NMDA receptors are necessary for auditory trace fear conditioning measured with conditioned hypoalgesia in rats.
Behav Brain Res. 2008 Oct 10; 192(2):264-8.BB

Abstract

We tested whether N-methyl-D-aspartate (NMDA) receptors in the dorsal hippocampus (DH) are critical for the acquisition of trace fear conditioning using conditioned hypoalgesia (CHA), decrease in pain reactivity, as the conditioned response (CR) instead of commonly used freezing. Infusions of the NMDA receptor antagonist, DL-2-amino-5-phosphonovaleric acid (APV) into DH prior to conditioning resulted in impaired CHA, measured with the radiant heat tail flick test, only in the trace-conditioning group when they were tested during the trace interval. The same infusion had no effect on CHA in the delay-conditioned animals. The results support that NMDA receptors in DH are critically involved in associating the CS with the US across a temporal gap. In addition, temporal specificity of the CR was revealed as CHA was induced only in the temporal vicinity of the US used for the training.

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Authors+Show Affiliations

Seo DO
Department of Psychology, Korea University, 5-1 Anam-Dong, Seongbuk-Gu, Seoul, 136-701, Republic of Korea.
Pang MH
No affiliation info available
Shin MS
No affiliation info available
Kim HT
No affiliation info available
Choi JS
No affiliation info available

MeSH

2-Amino-5-phosphonovalerateAcoustic StimulationAnimalsAssociation LearningBehavior, AnimalBrain InjuriesConditioning, ClassicalExcitatory Amino Acid AntagonistsFearHippocampusMaleMemoryMicroinjectionsRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateReflex, StartleTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18514922

Citation

Seo, Dong-Oh, et al. "Hippocampal NMDA Receptors Are Necessary for Auditory Trace Fear Conditioning Measured With Conditioned Hypoalgesia in Rats." Behavioural Brain Research, vol. 192, no. 2, 2008, pp. 264-8.
Seo DO, Pang MH, Shin MS, et al. Hippocampal NMDA receptors are necessary for auditory trace fear conditioning measured with conditioned hypoalgesia in rats. Behav Brain Res. 2008;192(2):264-8.
Seo, D. O., Pang, M. H., Shin, M. S., Kim, H. T., & Choi, J. S. (2008). Hippocampal NMDA receptors are necessary for auditory trace fear conditioning measured with conditioned hypoalgesia in rats. Behavioural Brain Research, 192(2), 264-8. https://doi.org/10.1016/j.bbr.2008.04.011
Seo DO, et al. Hippocampal NMDA Receptors Are Necessary for Auditory Trace Fear Conditioning Measured With Conditioned Hypoalgesia in Rats. Behav Brain Res. 2008 Oct 10;192(2):264-8. PubMed PMID: 18514922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal NMDA receptors are necessary for auditory trace fear conditioning measured with conditioned hypoalgesia in rats. AU - Seo,Dong-Oh, AU - Pang,Min-Hee, AU - Shin,Maeng-Sik, AU - Kim,Hyun-Taek, AU - Choi,June-Seek, Y1 - 2008/04/20/ PY - 2007/09/29/received PY - 2008/03/31/revised PY - 2008/04/09/accepted PY - 2008/6/3/pubmed PY - 2008/10/1/medline PY - 2008/6/3/entrez SP - 264 EP - 8 JF - Behavioural brain research JO - Behav Brain Res VL - 192 IS - 2 N2 - We tested whether N-methyl-D-aspartate (NMDA) receptors in the dorsal hippocampus (DH) are critical for the acquisition of trace fear conditioning using conditioned hypoalgesia (CHA), decrease in pain reactivity, as the conditioned response (CR) instead of commonly used freezing. Infusions of the NMDA receptor antagonist, DL-2-amino-5-phosphonovaleric acid (APV) into DH prior to conditioning resulted in impaired CHA, measured with the radiant heat tail flick test, only in the trace-conditioning group when they were tested during the trace interval. The same infusion had no effect on CHA in the delay-conditioned animals. The results support that NMDA receptors in DH are critically involved in associating the CS with the US across a temporal gap. In addition, temporal specificity of the CR was revealed as CHA was induced only in the temporal vicinity of the US used for the training. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/18514922/Hippocampal_NMDA_receptors_are_necessary_for_auditory_trace_fear_conditioning_measured_with_conditioned_hypoalgesia_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(08)00209-X DB - PRIME DP - Unbound Medicine ER -