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Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips.
J Ethnopharmacol. 2008 Jul 23; 118(2):290-4.JE

Abstract

This study aimed to assess the anti-inflammatory and analgesic effects of Fructus Rosae Multiflorae (FRM, hips of Rosa multiflora Thunb.). FRM was extracted with 75% ethanol and the dried extract (FRME) was administered intragastrically (i.g.) at 100, 200 and 400mg/kg. The anti-inflammatory effect was evaluated in four experimental animal models and analgesic effect in two animal models. Pretreatment with a single dose of FRME produced significant dose-dependent anti-inflammatory effects on carrageenin-induced rat hind paw edema, xylene-induced mouse ear edema and acetic acid-induced mouse vascular permeation. In a 7-day study, daily administration of FRME suppressed cotton pellet-induced rat granuloma formation. Pretreatment with a single dose of FRME also produced dose-dependent anti-nociceptive effects in thermally- and chemically induced mouse pain models. In addition, a single dose of FRME at 2.4g/kg body weight (equivalent to 87.6g of dried hips per kg body weight) produced no observable acute toxicity in mice within seven days. These results demonstrate that FRME possesses anti-inflammatory and analgesic effects and has no obvious acute toxicity, which advanced our understanding of the folk use of FRM in treating various inflammatory disorders.

Authors+Show Affiliations

Research Division of Pharmacology, China Pharmaceutical University, Nanjing 210009, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18515025

Citation

Zhang, Guang-Qin, et al. "Anti-inflammatory and Analgesic Effects of the Ethanol Extract of Rosa Multiflora Thunb. Hips." Journal of Ethnopharmacology, vol. 118, no. 2, 2008, pp. 290-4.
Zhang GQ, Huang XD, Wang H, et al. Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips. J Ethnopharmacol. 2008;118(2):290-4.
Zhang, G. Q., Huang, X. D., Wang, H., Leung, A. K., Chan, C. L., Fong, D. W., & Yu, Z. L. (2008). Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips. Journal of Ethnopharmacology, 118(2), 290-4. https://doi.org/10.1016/j.jep.2008.04.014
Zhang GQ, et al. Anti-inflammatory and Analgesic Effects of the Ethanol Extract of Rosa Multiflora Thunb. Hips. J Ethnopharmacol. 2008 Jul 23;118(2):290-4. PubMed PMID: 18515025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips. AU - Zhang,Guang-Qin, AU - Huang,Xiao-Dong, AU - Wang,Hui, AU - Leung,Alexander Kai-Nan, AU - Chan,Chi-Leung, AU - Fong,David W F, AU - Yu,Zhi-Ling, Y1 - 2008/04/20/ PY - 2007/08/23/received PY - 2008/04/01/revised PY - 2008/04/12/accepted PY - 2008/6/3/pubmed PY - 2008/12/17/medline PY - 2008/6/3/entrez SP - 290 EP - 4 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 118 IS - 2 N2 - This study aimed to assess the anti-inflammatory and analgesic effects of Fructus Rosae Multiflorae (FRM, hips of Rosa multiflora Thunb.). FRM was extracted with 75% ethanol and the dried extract (FRME) was administered intragastrically (i.g.) at 100, 200 and 400mg/kg. The anti-inflammatory effect was evaluated in four experimental animal models and analgesic effect in two animal models. Pretreatment with a single dose of FRME produced significant dose-dependent anti-inflammatory effects on carrageenin-induced rat hind paw edema, xylene-induced mouse ear edema and acetic acid-induced mouse vascular permeation. In a 7-day study, daily administration of FRME suppressed cotton pellet-induced rat granuloma formation. Pretreatment with a single dose of FRME also produced dose-dependent anti-nociceptive effects in thermally- and chemically induced mouse pain models. In addition, a single dose of FRME at 2.4g/kg body weight (equivalent to 87.6g of dried hips per kg body weight) produced no observable acute toxicity in mice within seven days. These results demonstrate that FRME possesses anti-inflammatory and analgesic effects and has no obvious acute toxicity, which advanced our understanding of the folk use of FRM in treating various inflammatory disorders. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18515025/Anti_inflammatory_and_analgesic_effects_of_the_ethanol_extract_of_Rosa_multiflora_Thunb__hips_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00217-1 DB - PRIME DP - Unbound Medicine ER -