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Bone mineral density and body composition in men with systemic lupus erythematosus: a case control study.
Bone. 2008 Aug; 43(2):327-31.BONE

Abstract

OBJECTIVE

To study the bone mineral density (BMD) and body composition in men with systemic lupus erythematosus (SLE).

METHODS

Consecutive male patients who fulfilled > or =4 ACR criteria for SLE and age-matched healthy men were recruited for measurement of BMD and body composition by DXA scan. Risk factors for low BMD in SLE patients were evaluated.

RESULTS

40 male SLE patients were studied (age 42.6+/-12 years; disease duration 84.7+/-79 months). 34 (85%) patients were treated with long-term glucocorticoids. Compared with 40 controls, SLE patients had a significantly lower BMD at the lumbar spine (0.96+/-0.16 vs 1.03+/-0.11 g/cm2; p=0.02) and the hip (0.87+/-0.14 vs 0.94+/-0.12 g/cm2; p=0.04). At the spine, 12 (30%) SLE patients had Z scores< - 2.0 and 2 (5%) had osteoporotic fractures. At the hip, 3 (7.5%) patients had Z scores< - 2.0 but none had hip fractures. The BMD Z scores at the femoral neck and spine were significantly lower in SLE patients than controls. The total lean body mass was also lower in patients than control subjects (46.4+/-7.3 vs 50.5+/-5.9 kg; p=0.01). Multiple regression revealed increasing age, habitual drinking, lower BMI and use of high-dose prednisolone were unfavorably associated with lower BMD at the spine in SLE patients.

CONCLUSIONS

Reduced BMD and lean body mass are prevalent in men with SLE. Appropriate measures against osteoporosis should be undertaken, especially in older patients with low BMI who receive high-dose glucocorticoids.

Authors+Show Affiliations

Department of Medicine and Nuclear Medicine, Tuen Mun Hospital, Hong Kong, China. ccmok2005@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18515206

Citation

Mok, Chi Chiu, et al. "Bone Mineral Density and Body Composition in Men With Systemic Lupus Erythematosus: a Case Control Study." Bone, vol. 43, no. 2, 2008, pp. 327-31.
Mok CC, Ying SK, To CH, et al. Bone mineral density and body composition in men with systemic lupus erythematosus: a case control study. Bone. 2008;43(2):327-31.
Mok, C. C., Ying, S. K., To, C. H., & Ma, K. M. (2008). Bone mineral density and body composition in men with systemic lupus erythematosus: a case control study. Bone, 43(2), 327-31. https://doi.org/10.1016/j.bone.2008.04.003
Mok CC, et al. Bone Mineral Density and Body Composition in Men With Systemic Lupus Erythematosus: a Case Control Study. Bone. 2008;43(2):327-31. PubMed PMID: 18515206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density and body composition in men with systemic lupus erythematosus: a case control study. AU - Mok,Chi Chiu, AU - Ying,Shirley King Yee, AU - To,Chi Hung, AU - Ma,Kwok Man, Y1 - 2008/04/18/ PY - 2007/10/09/received PY - 2008/04/01/revised PY - 2008/04/07/accepted PY - 2008/6/3/pubmed PY - 2008/9/27/medline PY - 2008/6/3/entrez SP - 327 EP - 31 JF - Bone JO - Bone VL - 43 IS - 2 N2 - OBJECTIVE: To study the bone mineral density (BMD) and body composition in men with systemic lupus erythematosus (SLE). METHODS: Consecutive male patients who fulfilled > or =4 ACR criteria for SLE and age-matched healthy men were recruited for measurement of BMD and body composition by DXA scan. Risk factors for low BMD in SLE patients were evaluated. RESULTS: 40 male SLE patients were studied (age 42.6+/-12 years; disease duration 84.7+/-79 months). 34 (85%) patients were treated with long-term glucocorticoids. Compared with 40 controls, SLE patients had a significantly lower BMD at the lumbar spine (0.96+/-0.16 vs 1.03+/-0.11 g/cm2; p=0.02) and the hip (0.87+/-0.14 vs 0.94+/-0.12 g/cm2; p=0.04). At the spine, 12 (30%) SLE patients had Z scores< - 2.0 and 2 (5%) had osteoporotic fractures. At the hip, 3 (7.5%) patients had Z scores< - 2.0 but none had hip fractures. The BMD Z scores at the femoral neck and spine were significantly lower in SLE patients than controls. The total lean body mass was also lower in patients than control subjects (46.4+/-7.3 vs 50.5+/-5.9 kg; p=0.01). Multiple regression revealed increasing age, habitual drinking, lower BMI and use of high-dose prednisolone were unfavorably associated with lower BMD at the spine in SLE patients. CONCLUSIONS: Reduced BMD and lean body mass are prevalent in men with SLE. Appropriate measures against osteoporosis should be undertaken, especially in older patients with low BMI who receive high-dose glucocorticoids. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/18515206/Bone_mineral_density_and_body_composition_in_men_with_systemic_lupus_erythematosus:_a_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(08)00187-7 DB - PRIME DP - Unbound Medicine ER -