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Evaluation of circulating amino terminal-pro-B-type natriuretic peptide concentration in dogs with respiratory distress attributable to congestive heart failure or primary pulmonary disease.
J Am Vet Med Assoc. 2008 Jun 01; 232(11):1674-9.JA

Abstract

OBJECTIVE

To evaluate assessment of circulating amino terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration as a means to discriminate between congestive heart failure and primary pulmonary disease in dogs.

DESIGN

Prospective case series.

ANIMALS

46 dogs with signs of respiratory distress or coughing.

PROCEDURES

All dogs underwent physical and thoracic radiographic examinations. Dogs with evidence of heart disease (eg, murmur, arrhythmia, or large cardiac silhouette detected by radiography) also underwent echocardiography. Dogs with no evidence of heart disease or failure were included if they underwent bronchoalveolar lavage (with cytologic examination and bacterial culture of the lavage fluid). Blood samples for NT-proBNP assay were obtained within 12 hours of the diagnosis of heart failure or prior to bronchoalveolar lavage in dogs with primary pulmonary disease. Circulating concentrations of NT-proBNP were compared between groups and correlated with radiographic and echocardiographic measures of cardiac size.

RESULTS

Congestive heart failure and primary pulmonary disease were diagnosed in 25 and 21 dogs, respectively. Dogs with congestive heart failure had significantly higher median serum or plasma NT-proBNP concentration (2,554 pmol/L; interquartile [25% to 75%] range, 1,651.5 to 3,475.5 pmol/L) than dogs with primary pulmonary disease (357 pmol/L; interquartile range, 192.5 to 565.5 pmol/L). Radiographic vertebral heart score and echocardiographic left atrial-to-aortic diameter ratio were not correlated with NT-proBNP concentration. Left ventricular end-diastolic diameter (measured echocardiographically) and NT-proBNP concentration were weakly correlated.

CONCLUSIONS AND CLINICAL RELEVANCE

Serum or plasma NT-proBNP concentration assessment may be useful for discrimination of congestive heart failure from primary pulmonary disease in dogs with respiratory distress or cough.

Authors+Show Affiliations

Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18518809

Citation

Fine, Deborah M., et al. "Evaluation of Circulating Amino terminal-pro-B-type Natriuretic Peptide Concentration in Dogs With Respiratory Distress Attributable to Congestive Heart Failure or Primary Pulmonary Disease." Journal of the American Veterinary Medical Association, vol. 232, no. 11, 2008, pp. 1674-9.
Fine DM, DeClue AE, Reinero CR. Evaluation of circulating amino terminal-pro-B-type natriuretic peptide concentration in dogs with respiratory distress attributable to congestive heart failure or primary pulmonary disease. J Am Vet Med Assoc. 2008;232(11):1674-9.
Fine, D. M., DeClue, A. E., & Reinero, C. R. (2008). Evaluation of circulating amino terminal-pro-B-type natriuretic peptide concentration in dogs with respiratory distress attributable to congestive heart failure or primary pulmonary disease. Journal of the American Veterinary Medical Association, 232(11), 1674-9. https://doi.org/10.2460/javma.232.11.1674
Fine DM, DeClue AE, Reinero CR. Evaluation of Circulating Amino terminal-pro-B-type Natriuretic Peptide Concentration in Dogs With Respiratory Distress Attributable to Congestive Heart Failure or Primary Pulmonary Disease. J Am Vet Med Assoc. 2008 Jun 1;232(11):1674-9. PubMed PMID: 18518809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of circulating amino terminal-pro-B-type natriuretic peptide concentration in dogs with respiratory distress attributable to congestive heart failure or primary pulmonary disease. AU - Fine,Deborah M, AU - DeClue,Amy E, AU - Reinero,Carol R, PY - 2008/6/4/pubmed PY - 2008/7/9/medline PY - 2008/6/4/entrez SP - 1674 EP - 9 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 232 IS - 11 N2 - OBJECTIVE: To evaluate assessment of circulating amino terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration as a means to discriminate between congestive heart failure and primary pulmonary disease in dogs. DESIGN: Prospective case series. ANIMALS: 46 dogs with signs of respiratory distress or coughing. PROCEDURES: All dogs underwent physical and thoracic radiographic examinations. Dogs with evidence of heart disease (eg, murmur, arrhythmia, or large cardiac silhouette detected by radiography) also underwent echocardiography. Dogs with no evidence of heart disease or failure were included if they underwent bronchoalveolar lavage (with cytologic examination and bacterial culture of the lavage fluid). Blood samples for NT-proBNP assay were obtained within 12 hours of the diagnosis of heart failure or prior to bronchoalveolar lavage in dogs with primary pulmonary disease. Circulating concentrations of NT-proBNP were compared between groups and correlated with radiographic and echocardiographic measures of cardiac size. RESULTS: Congestive heart failure and primary pulmonary disease were diagnosed in 25 and 21 dogs, respectively. Dogs with congestive heart failure had significantly higher median serum or plasma NT-proBNP concentration (2,554 pmol/L; interquartile [25% to 75%] range, 1,651.5 to 3,475.5 pmol/L) than dogs with primary pulmonary disease (357 pmol/L; interquartile range, 192.5 to 565.5 pmol/L). Radiographic vertebral heart score and echocardiographic left atrial-to-aortic diameter ratio were not correlated with NT-proBNP concentration. Left ventricular end-diastolic diameter (measured echocardiographically) and NT-proBNP concentration were weakly correlated. CONCLUSIONS AND CLINICAL RELEVANCE: Serum or plasma NT-proBNP concentration assessment may be useful for discrimination of congestive heart failure from primary pulmonary disease in dogs with respiratory distress or cough. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/18518809/Evaluation_of_circulating_amino_terminal_pro_B_type_natriuretic_peptide_concentration_in_dogs_with_respiratory_distress_attributable_to_congestive_heart_failure_or_primary_pulmonary_disease_ L2 - https://avmajournals.avma.org/doi/10.2460/javma.232.11.1674?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -