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Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities.
Pediatrics. 2008 Jun; 121(6):1155-64.Ped

Abstract

OBJECTIVES

The objectives of this study were to compare the birth weight and gestational age distributions and prevalence rates of autism with those of other developmental disabilities and to estimate the birth weight-and gestational age-specific risks for autism.

METHODS

For the first objective, a retrospective cohort of children born in Atlanta, Georgia, in 1981-1993 who survived to 3 years of age was identified through vital records. Children in the cohort who had developmental disabilities (autism, mental retardation, cerebral palsy, hearing loss, or vision impairment) and were still residing in metropolitan Atlanta at 3 to 10 years of age were identified through the Metropolitan Atlanta Developmental Disabilities Surveillance Program. A nested case-control sample from the cohort was used for the second objective; all cohort children identified with autism were case participants, and control participants were cohort children who were not identified as having developmental disabilities or receiving special education services.

RESULTS

The prevalence of autism in low birth weight or preterm children was markedly lower than those of other developmental disabilities. In multivariate analyses, birth weight of <2500 g and preterm birth at <33 weeks' gestation were associated with an approximately twofold increased risk for autism, although the magnitude of risk from these factors varied according to gender (higher in girls) and autism subgroup (higher for autism accompanied by other developmental disabilities). For example, a significant fourfold increased risk was observed in low birth weight girls for autism accompanied by mental retardation, whereas there was no significantly increased risk observed in low birth weight boys for autism alone.

CONCLUSIONS

Gender and autism subgroup differences in birth weight and gestational age, resulting in lower gender ratios with declining birth weight or gestational age across all autism subgroups, might be markers for etiologic heterogeneity in autism.

Authors+Show Affiliations

National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Rd, Mail Stop E-86, Atlanta, GA 30333, USA. dschendel@cdc.govNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18519485

Citation

Schendel, Diana, and Tanya Karapurkar Bhasin. "Birth Weight and Gestational Age Characteristics of Children With Autism, Including a Comparison With Other Developmental Disabilities." Pediatrics, vol. 121, no. 6, 2008, pp. 1155-64.
Schendel D, Bhasin TK. Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities. Pediatrics. 2008;121(6):1155-64.
Schendel, D., & Bhasin, T. K. (2008). Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities. Pediatrics, 121(6), 1155-64. https://doi.org/10.1542/peds.2007-1049
Schendel D, Bhasin TK. Birth Weight and Gestational Age Characteristics of Children With Autism, Including a Comparison With Other Developmental Disabilities. Pediatrics. 2008;121(6):1155-64. PubMed PMID: 18519485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities. AU - Schendel,Diana, AU - Bhasin,Tanya Karapurkar, PY - 2008/6/4/pubmed PY - 2008/8/12/medline PY - 2008/6/4/entrez SP - 1155 EP - 64 JF - Pediatrics JO - Pediatrics VL - 121 IS - 6 N2 - OBJECTIVES: The objectives of this study were to compare the birth weight and gestational age distributions and prevalence rates of autism with those of other developmental disabilities and to estimate the birth weight-and gestational age-specific risks for autism. METHODS: For the first objective, a retrospective cohort of children born in Atlanta, Georgia, in 1981-1993 who survived to 3 years of age was identified through vital records. Children in the cohort who had developmental disabilities (autism, mental retardation, cerebral palsy, hearing loss, or vision impairment) and were still residing in metropolitan Atlanta at 3 to 10 years of age were identified through the Metropolitan Atlanta Developmental Disabilities Surveillance Program. A nested case-control sample from the cohort was used for the second objective; all cohort children identified with autism were case participants, and control participants were cohort children who were not identified as having developmental disabilities or receiving special education services. RESULTS: The prevalence of autism in low birth weight or preterm children was markedly lower than those of other developmental disabilities. In multivariate analyses, birth weight of <2500 g and preterm birth at <33 weeks' gestation were associated with an approximately twofold increased risk for autism, although the magnitude of risk from these factors varied according to gender (higher in girls) and autism subgroup (higher for autism accompanied by other developmental disabilities). For example, a significant fourfold increased risk was observed in low birth weight girls for autism accompanied by mental retardation, whereas there was no significantly increased risk observed in low birth weight boys for autism alone. CONCLUSIONS: Gender and autism subgroup differences in birth weight and gestational age, resulting in lower gender ratios with declining birth weight or gestational age across all autism subgroups, might be markers for etiologic heterogeneity in autism. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/18519485/Birth_weight_and_gestational_age_characteristics_of_children_with_autism_including_a_comparison_with_other_developmental_disabilities_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&amp;pmid=18519485 DB - PRIME DP - Unbound Medicine ER -