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Interaction of tomato lycopene and ketosamine against rat prostate tumorigenesis.
Cancer Res. 2008 Jun 01; 68(11):4384-91.CR

Abstract

Prior investigations on the beneficial effect of dietary processed tomato products and lycopene on prostate cancer risk suggested that lycopene may require the presence of other constituents to exert its chemopreventive potential. We investigated whether ketosamines, a group of carbohydrate derivatives present in dehydrated tomato products, may interact with lycopene against prostate tumorigenesis. One ketosamine, FruHis, strongly synergized with lycopene against proliferation of the highly metastatic rat prostate adenocarcinoma MAT-LyLu cell line in vitro. The FruHis/lycopene combination significantly inhibited in vivo tumor formation by MAT-LyLu cells in syngeneic Copenhagen rats. Energy-balanced diets, supplemented with tomato paste, tomato powder, or tomato paste plus FruHis, were fed to Wistar-Unilever rats (n = 20 per group) treated with N-nitroso-N-methylurea and testosterone to induce prostate carcinogenesis. Survival from carcinogenesis was lowest in the control group (median survival time, 40 weeks) and highest in the group fed the tomato paste/FruHis diet (51 weeks; P = 0.004, versus control). The proportions of dying rats with macroscopic prostate tumors in the control, tomato paste, tomato powder, and tomato paste/FruHis groups were 63% (12 of 19), 39% (5 of 13), 43% (6 of 14), and 18% (2 of 11), respectively. FruHis completely blocked DNA oxidative degradation at >250 micromol/L in vitro, whereas neither ascorbate nor phenolic antioxidants from tomato were effective protectors in this assay. FruHis, therefore, may exert tumor-preventive effect through its antioxidant activity and interaction with lycopene.

Authors+Show Affiliations

Department of Biochemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA. MossineV@missouri.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18519700

Citation

Mossine, Valeri V., et al. "Interaction of Tomato Lycopene and Ketosamine Against Rat Prostate Tumorigenesis." Cancer Research, vol. 68, no. 11, 2008, pp. 4384-91.
Mossine VV, Chopra P, Mawhinney TP. Interaction of tomato lycopene and ketosamine against rat prostate tumorigenesis. Cancer Res. 2008;68(11):4384-91.
Mossine, V. V., Chopra, P., & Mawhinney, T. P. (2008). Interaction of tomato lycopene and ketosamine against rat prostate tumorigenesis. Cancer Research, 68(11), 4384-91. https://doi.org/10.1158/0008-5472.CAN-08-0108
Mossine VV, Chopra P, Mawhinney TP. Interaction of Tomato Lycopene and Ketosamine Against Rat Prostate Tumorigenesis. Cancer Res. 2008 Jun 1;68(11):4384-91. PubMed PMID: 18519700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of tomato lycopene and ketosamine against rat prostate tumorigenesis. AU - Mossine,Valeri V, AU - Chopra,Pankaj, AU - Mawhinney,Thomas P, PY - 2008/6/4/pubmed PY - 2008/8/16/medline PY - 2008/6/4/entrez SP - 4384 EP - 91 JF - Cancer research JO - Cancer Res. VL - 68 IS - 11 N2 - Prior investigations on the beneficial effect of dietary processed tomato products and lycopene on prostate cancer risk suggested that lycopene may require the presence of other constituents to exert its chemopreventive potential. We investigated whether ketosamines, a group of carbohydrate derivatives present in dehydrated tomato products, may interact with lycopene against prostate tumorigenesis. One ketosamine, FruHis, strongly synergized with lycopene against proliferation of the highly metastatic rat prostate adenocarcinoma MAT-LyLu cell line in vitro. The FruHis/lycopene combination significantly inhibited in vivo tumor formation by MAT-LyLu cells in syngeneic Copenhagen rats. Energy-balanced diets, supplemented with tomato paste, tomato powder, or tomato paste plus FruHis, were fed to Wistar-Unilever rats (n = 20 per group) treated with N-nitroso-N-methylurea and testosterone to induce prostate carcinogenesis. Survival from carcinogenesis was lowest in the control group (median survival time, 40 weeks) and highest in the group fed the tomato paste/FruHis diet (51 weeks; P = 0.004, versus control). The proportions of dying rats with macroscopic prostate tumors in the control, tomato paste, tomato powder, and tomato paste/FruHis groups were 63% (12 of 19), 39% (5 of 13), 43% (6 of 14), and 18% (2 of 11), respectively. FruHis completely blocked DNA oxidative degradation at >250 micromol/L in vitro, whereas neither ascorbate nor phenolic antioxidants from tomato were effective protectors in this assay. FruHis, therefore, may exert tumor-preventive effect through its antioxidant activity and interaction with lycopene. SN - 1538-7445 UR - https://www.unboundmedicine.com/medline/citation/18519700/Interaction_of_tomato_lycopene_and_ketosamine_against_rat_prostate_tumorigenesis_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18519700 DB - PRIME DP - Unbound Medicine ER -