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Preparation and in vivo evaluation of piroxicam-loaded gelatin microcapsule by spray drying technique.
Biol Pharm Bull. 2008 Jun; 31(6):1284-7.BP

Abstract

To develop a piroxicam-loaded gelatin microcapsule with enhanced bioavailability, a gelatin microcapsule encapsulated ethanol and piroxicam has been formulated by using gelatin as a water-soluble polymer shell. The aqueous solubility and bioavailability of piroxicam in piroxicam-loaded microcapsule in rats were then evaluated compared to piroxicam powder. The piroxicam-loaded gelatin microcapsule spherical in shape with smooth surface showed the geometric mean diameter of about 19 microm. It had the piroxicam solubility of about 1.87 mg/ml and the amount of ethanol of about 4.37 microg/mg. Furthermore, it gave significantly higher total plasma concentrations, Cmax and area under the blood concentration-time curve (AUC) of piroxicam in rats than did piroxicam powder, indicating that the drug from gelatin microcapsule could be more orally absorbed in rats. In particular, the AUC of piroxicam in gelatin microcapsule was significantly about 2 fold increased compared to piroxicam powder. This enhanced oral relative bioavailability of piroxicam in gelatin microcapsule was contributed by the marked increase in the absorption rate of piroxicam due to the improved solubility of piroxicam. Thus, the piroxicam-loaded gelatin microcapsule developed using spray-drying technique with gelatin, sodium lauryl sulfate and ethanol would be useful to deliver piroxicam in a pattern that allows fast absorption in the initial phase, leading to better absorption.

Authors+Show Affiliations

College of Pharmacy, Yeungnam University, Gyongsan, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18520070

Citation

Piao, Ming Guan, et al. "Preparation and in Vivo Evaluation of Piroxicam-loaded Gelatin Microcapsule By Spray Drying Technique." Biological & Pharmaceutical Bulletin, vol. 31, no. 6, 2008, pp. 1284-7.
Piao MG, Yang CW, Li DX, et al. Preparation and in vivo evaluation of piroxicam-loaded gelatin microcapsule by spray drying technique. Biol Pharm Bull. 2008;31(6):1284-7.
Piao, M. G., Yang, C. W., Li, D. X., Kim, J. O., Jang, K. Y., Yoo, B. K., Kim, J. A., Woo, J. S., Lyoo, W. S., Han, S. S., Lee, Y. B., Kim, D. D., Yong, C. S., & Choi, H. G. (2008). Preparation and in vivo evaluation of piroxicam-loaded gelatin microcapsule by spray drying technique. Biological & Pharmaceutical Bulletin, 31(6), 1284-7.
Piao MG, et al. Preparation and in Vivo Evaluation of Piroxicam-loaded Gelatin Microcapsule By Spray Drying Technique. Biol Pharm Bull. 2008;31(6):1284-7. PubMed PMID: 18520070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and in vivo evaluation of piroxicam-loaded gelatin microcapsule by spray drying technique. AU - Piao,Ming Guan, AU - Yang,Chan-Woo, AU - Li,Dong Xun, AU - Kim,Jong Oh, AU - Jang,Ki-Young, AU - Yoo,Bong Kyu, AU - Kim,Jung Ae, AU - Woo,Jong Soo, AU - Lyoo,Won Seok, AU - Han,Sung Soo, AU - Lee,Yong-Bok, AU - Kim,Dae-Duk, AU - Yong,Chul Soon, AU - Choi,Han Gon, PY - 2008/6/4/pubmed PY - 2008/7/1/medline PY - 2008/6/4/entrez SP - 1284 EP - 7 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 31 IS - 6 N2 - To develop a piroxicam-loaded gelatin microcapsule with enhanced bioavailability, a gelatin microcapsule encapsulated ethanol and piroxicam has been formulated by using gelatin as a water-soluble polymer shell. The aqueous solubility and bioavailability of piroxicam in piroxicam-loaded microcapsule in rats were then evaluated compared to piroxicam powder. The piroxicam-loaded gelatin microcapsule spherical in shape with smooth surface showed the geometric mean diameter of about 19 microm. It had the piroxicam solubility of about 1.87 mg/ml and the amount of ethanol of about 4.37 microg/mg. Furthermore, it gave significantly higher total plasma concentrations, Cmax and area under the blood concentration-time curve (AUC) of piroxicam in rats than did piroxicam powder, indicating that the drug from gelatin microcapsule could be more orally absorbed in rats. In particular, the AUC of piroxicam in gelatin microcapsule was significantly about 2 fold increased compared to piroxicam powder. This enhanced oral relative bioavailability of piroxicam in gelatin microcapsule was contributed by the marked increase in the absorption rate of piroxicam due to the improved solubility of piroxicam. Thus, the piroxicam-loaded gelatin microcapsule developed using spray-drying technique with gelatin, sodium lauryl sulfate and ethanol would be useful to deliver piroxicam in a pattern that allows fast absorption in the initial phase, leading to better absorption. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/18520070/Preparation_and_in_vivo_evaluation_of_piroxicam_loaded_gelatin_microcapsule_by_spray_drying_technique_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/31.1284?from=PubMed DB - PRIME DP - Unbound Medicine ER -