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Effects on spinal cord blood flow and neurologic function secondary to interruption of bilateral segmental arteries which supply the artery of Adamkiewicz: an experimental study using a dog model.
Spine (Phila Pa 1976). 2008 Jun 15; 33(14):1533-41.S

Abstract

STUDY DESIGN

Segmental arteries including the level of Adamkiewicz artery were interrupted bilaterally for up to 4 levels to study the effects on spinal cord blood flow and neurologic function in dogs.

OBJECTIVE

To examine how many ligations of bilateral segmental arteries including the level of Adamkiewicz artery cause ischemic spinal cord dysfunction.

SUMMARY OF BACKGROUND DATA

Interruption of bilateral segmental arteries at >or=5 consecutive levels without the level of Adamkiewicz artery has been reported to risk producing ischemic spinal cord dysfunction in dog model. However, the effects of ligating including the level of Adamkiewicz artery have not been elucidated.

METHODS

The 25 dogs in which Adamkiewicz artery originated from L5 level were taken in this study. There were 15 dogs divided into 5 groups: sham group, no ligation; group 1, ligation of bilateral segmental arteries at 1 level (L5); group 2, at 2 levels (L4-L5); group 3, at 3 levels (L4-L6); and group 4, at 4 levels (L3-L6). Spinal cord blood flow at the L5 spinal cord segment by laser-Doppler flowmetry, and spinal cord-evoked and compound muscle action potentials were measured simultaneously until 10 hours after ligation. Neurologic function was assessed using a modified Tarlov grading system 1 week after operation in 10 other dogs divided into 2 groups: 3 pairs group, ligation at 3 levels (L4-L6); 4 pairs group, at 4 levels (L3-L6).

RESULTS

Spinal cord blood flow was 98.2%, 76.1%, 66.6%, 61.4%, and 53.5% in the sham group, groups 1, 2, 3, and 4, respectively, 10 hours after ligation. Abnormal spinal cord-evoked and compound muscle action potentials were observed in 1 out of 3 dogs in group 4. Postoperative neurologic evaluation identified all 5 dogs in 3 pairs group and 4 in 4 pairs group as having grade 5. There was 1 dog in 4 pairs group that had grade 4.

CONCLUSION

Interruption of bilateral segmental arteries at >or=4 consecutive levels including the level of Adamkiewicz artery risks producing ischemic spinal cord dysfunction.

Authors+Show Affiliations

Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan. seikei@pop01.kanazawa-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18520634

Citation

Kato, Satoshi, et al. "Effects On Spinal Cord Blood Flow and Neurologic Function Secondary to Interruption of Bilateral Segmental Arteries Which Supply the Artery of Adamkiewicz: an Experimental Study Using a Dog Model." Spine, vol. 33, no. 14, 2008, pp. 1533-41.
Kato S, Kawahara N, Tomita K, et al. Effects on spinal cord blood flow and neurologic function secondary to interruption of bilateral segmental arteries which supply the artery of Adamkiewicz: an experimental study using a dog model. Spine. 2008;33(14):1533-41.
Kato, S., Kawahara, N., Tomita, K., Murakami, H., Demura, S., & Fujimaki, Y. (2008). Effects on spinal cord blood flow and neurologic function secondary to interruption of bilateral segmental arteries which supply the artery of Adamkiewicz: an experimental study using a dog model. Spine, 33(14), 1533-41. https://doi.org/10.1097/BRS.0b013e318178e5af
Kato S, et al. Effects On Spinal Cord Blood Flow and Neurologic Function Secondary to Interruption of Bilateral Segmental Arteries Which Supply the Artery of Adamkiewicz: an Experimental Study Using a Dog Model. Spine. 2008 Jun 15;33(14):1533-41. PubMed PMID: 18520634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects on spinal cord blood flow and neurologic function secondary to interruption of bilateral segmental arteries which supply the artery of Adamkiewicz: an experimental study using a dog model. AU - Kato,Satoshi, AU - Kawahara,Norio, AU - Tomita,Katsuro, AU - Murakami,Hideki, AU - Demura,Satoru, AU - Fujimaki,Yoshiyasu, PY - 2008/6/4/pubmed PY - 2008/9/4/medline PY - 2008/6/4/entrez SP - 1533 EP - 41 JF - Spine JO - Spine VL - 33 IS - 14 N2 - STUDY DESIGN: Segmental arteries including the level of Adamkiewicz artery were interrupted bilaterally for up to 4 levels to study the effects on spinal cord blood flow and neurologic function in dogs. OBJECTIVE: To examine how many ligations of bilateral segmental arteries including the level of Adamkiewicz artery cause ischemic spinal cord dysfunction. SUMMARY OF BACKGROUND DATA: Interruption of bilateral segmental arteries at >or=5 consecutive levels without the level of Adamkiewicz artery has been reported to risk producing ischemic spinal cord dysfunction in dog model. However, the effects of ligating including the level of Adamkiewicz artery have not been elucidated. METHODS: The 25 dogs in which Adamkiewicz artery originated from L5 level were taken in this study. There were 15 dogs divided into 5 groups: sham group, no ligation; group 1, ligation of bilateral segmental arteries at 1 level (L5); group 2, at 2 levels (L4-L5); group 3, at 3 levels (L4-L6); and group 4, at 4 levels (L3-L6). Spinal cord blood flow at the L5 spinal cord segment by laser-Doppler flowmetry, and spinal cord-evoked and compound muscle action potentials were measured simultaneously until 10 hours after ligation. Neurologic function was assessed using a modified Tarlov grading system 1 week after operation in 10 other dogs divided into 2 groups: 3 pairs group, ligation at 3 levels (L4-L6); 4 pairs group, at 4 levels (L3-L6). RESULTS: Spinal cord blood flow was 98.2%, 76.1%, 66.6%, 61.4%, and 53.5% in the sham group, groups 1, 2, 3, and 4, respectively, 10 hours after ligation. Abnormal spinal cord-evoked and compound muscle action potentials were observed in 1 out of 3 dogs in group 4. Postoperative neurologic evaluation identified all 5 dogs in 3 pairs group and 4 in 4 pairs group as having grade 5. There was 1 dog in 4 pairs group that had grade 4. CONCLUSION: Interruption of bilateral segmental arteries at >or=4 consecutive levels including the level of Adamkiewicz artery risks producing ischemic spinal cord dysfunction. SN - 1528-1159 UR - https://www.unboundmedicine.com/medline/citation/18520634/Effects_on_spinal_cord_blood_flow_and_neurologic_function_secondary_to_interruption_of_bilateral_segmental_arteries_which_supply_the_artery_of_Adamkiewicz:_an_experimental_study_using_a_dog_model_ L2 - http://dx.doi.org/10.1097/BRS.0b013e318178e5af DB - PRIME DP - Unbound Medicine ER -