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Are cannabinoids a new treatment option for pain in patients with fibromyalgia?
Nat Clin Pract Rheumatol. 2008 Jul; 4(7):348-9.NC

Abstract

Preliminary studies suggest that the synthetic cannabinoid nabilone might be an effective therapy in patients with fibromyalgia. Skrabek et al. performed a double-blind, randomized, placebo-controlled clinical trial to analyze the effects of nabilone on pain and quality of life in patients with fibromyalgia. After 4 weeks of treatment (0.5 mg once daily in week 1, 0.5 mg twice daily in week 2, 0.5 mg in the morning and 1 mg in the evening in week 3, and 1 mg twice daily in week 4), patients who received nabilone (n = 15) experienced significant improvements in clinical pain, measured on a visual analog scale (P <0.02), Fibromyalgia Impact Questionnaire score (P <0.02) and the 10-point anxiety scale of the Fibromyalgia Impact Questionnaire (P <0.02). After a 4-week wash-out period at the end of the trial, all benefits were lost in the nabilone cohort, which returned to their baseline levels of pain and quality of life. Patients who received placebo (n = 18) experienced no change throughout the study. Although nabilone was not associated with serious adverse effects, some patients did experience drowsiness, dry mouth, vertigo and ataxia as a result of treatment.

Authors+Show Affiliations

College of Medicine and Center for Musculoskeletal Pain Research, University of Florida, Gainesville, FL 32610-0221, USA. staudr@ufl.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18521112

Citation

Staud, Roland, and Eubee B. Koo. "Are Cannabinoids a New Treatment Option for Pain in Patients With Fibromyalgia?" Nature Clinical Practice. Rheumatology, vol. 4, no. 7, 2008, pp. 348-9.
Staud R, Koo EB. Are cannabinoids a new treatment option for pain in patients with fibromyalgia? Nat Clin Pract Rheumatol. 2008;4(7):348-9.
Staud, R., & Koo, E. B. (2008). Are cannabinoids a new treatment option for pain in patients with fibromyalgia? Nature Clinical Practice. Rheumatology, 4(7), 348-9. https://doi.org/10.1038/ncprheum0826
Staud R, Koo EB. Are Cannabinoids a New Treatment Option for Pain in Patients With Fibromyalgia. Nat Clin Pract Rheumatol. 2008;4(7):348-9. PubMed PMID: 18521112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are cannabinoids a new treatment option for pain in patients with fibromyalgia? AU - Staud,Roland, AU - Koo,Eubee B, Y1 - 2008/06/03/ PY - 2008/02/11/received PY - 2008/04/14/accepted PY - 2008/6/4/pubmed PY - 2008/6/4/medline PY - 2008/6/4/entrez SP - 348 EP - 9 JF - Nature clinical practice. Rheumatology JO - Nat Clin Pract Rheumatol VL - 4 IS - 7 N2 - Preliminary studies suggest that the synthetic cannabinoid nabilone might be an effective therapy in patients with fibromyalgia. Skrabek et al. performed a double-blind, randomized, placebo-controlled clinical trial to analyze the effects of nabilone on pain and quality of life in patients with fibromyalgia. After 4 weeks of treatment (0.5 mg once daily in week 1, 0.5 mg twice daily in week 2, 0.5 mg in the morning and 1 mg in the evening in week 3, and 1 mg twice daily in week 4), patients who received nabilone (n = 15) experienced significant improvements in clinical pain, measured on a visual analog scale (P <0.02), Fibromyalgia Impact Questionnaire score (P <0.02) and the 10-point anxiety scale of the Fibromyalgia Impact Questionnaire (P <0.02). After a 4-week wash-out period at the end of the trial, all benefits were lost in the nabilone cohort, which returned to their baseline levels of pain and quality of life. Patients who received placebo (n = 18) experienced no change throughout the study. Although nabilone was not associated with serious adverse effects, some patients did experience drowsiness, dry mouth, vertigo and ataxia as a result of treatment. SN - 1745-8390 UR - https://www.unboundmedicine.com/medline/citation/18521112/Are_cannabinoids_a_new_treatment_option_for_pain_in_patients_with_fibromyalgia L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=18521112.ui DB - PRIME DP - Unbound Medicine ER -
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