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Deep vein thrombosis in patients with chronic kidney disease.
Thromb Haemost 2008; 99(6):1035-9TH

Abstract

Deep vein thrombosis (DVT) is a poorly understood complication of chronic kidney disease (CKD). The objective of our analysis was to profile DVT patients with and without CKD. We defined CKD as patients requiring dialysis or patients having nephrotic syndrome. We compared 268 patients with CKD (184 patients with dialysis-dependent renal disease and 84 with nephrotic syndrome) to 4,307 patients with preserved renal function from a prospective United States multicenter deep venous thrombosis (DVT) registry. Compared with non-CKD patients, CKD patients with DVT were younger (median age 62 vs. 69 years, p < 0.0001), more often African-American (p < 0.0001), and more often Hispanic (p = 0.0003). CKD patients underwent surgery more frequently in the three months prior to developing DVT (48.9% vs. 39.0%, p = 0.001) and more often had concomitant congestive heart failure (20.9% vs. 14.6%, p = 0.005). CKD patients suffered upper extremity DVT more frequently (30.0% vs. 10.8%, p < 0.0001). Patients with CKD presented less often with typical DVT symptoms of extremity discomfort (42.9% vs. 52.4%, p = 0.003) and difficulty ambulating (5.4% vs. 10.1%, p = 0.01). Prophylaxis rates prior to DVT were similarly low in CKD and non-CKD patients (44.2% vs. 38.0%, p = 0.06). Future studies of DVT in CKD patients should explore novel strategies for improving prophylaxis utilization and the detection of DVT in this special population.

Authors+Show Affiliations

Cardiovascular Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18521505

Citation

Daneschvar, H Leon, et al. "Deep Vein Thrombosis in Patients With Chronic Kidney Disease." Thrombosis and Haemostasis, vol. 99, no. 6, 2008, pp. 1035-9.
Daneschvar HL, Seddighzadeh A, Piazza G, et al. Deep vein thrombosis in patients with chronic kidney disease. Thromb Haemost. 2008;99(6):1035-9.
Daneschvar, H. L., Seddighzadeh, A., Piazza, G., & Goldhaber, S. Z. (2008). Deep vein thrombosis in patients with chronic kidney disease. Thrombosis and Haemostasis, 99(6), pp. 1035-9. doi:10.1160/TH08-02-0107.
Daneschvar HL, et al. Deep Vein Thrombosis in Patients With Chronic Kidney Disease. Thromb Haemost. 2008;99(6):1035-9. PubMed PMID: 18521505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deep vein thrombosis in patients with chronic kidney disease. AU - Daneschvar,H Leon, AU - Seddighzadeh,Ali, AU - Piazza,Gregory, AU - Goldhaber,Samuel Z, PY - 2008/6/4/pubmed PY - 2008/8/5/medline PY - 2008/6/4/entrez SP - 1035 EP - 9 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 99 IS - 6 N2 - Deep vein thrombosis (DVT) is a poorly understood complication of chronic kidney disease (CKD). The objective of our analysis was to profile DVT patients with and without CKD. We defined CKD as patients requiring dialysis or patients having nephrotic syndrome. We compared 268 patients with CKD (184 patients with dialysis-dependent renal disease and 84 with nephrotic syndrome) to 4,307 patients with preserved renal function from a prospective United States multicenter deep venous thrombosis (DVT) registry. Compared with non-CKD patients, CKD patients with DVT were younger (median age 62 vs. 69 years, p < 0.0001), more often African-American (p < 0.0001), and more often Hispanic (p = 0.0003). CKD patients underwent surgery more frequently in the three months prior to developing DVT (48.9% vs. 39.0%, p = 0.001) and more often had concomitant congestive heart failure (20.9% vs. 14.6%, p = 0.005). CKD patients suffered upper extremity DVT more frequently (30.0% vs. 10.8%, p < 0.0001). Patients with CKD presented less often with typical DVT symptoms of extremity discomfort (42.9% vs. 52.4%, p = 0.003) and difficulty ambulating (5.4% vs. 10.1%, p = 0.01). Prophylaxis rates prior to DVT were similarly low in CKD and non-CKD patients (44.2% vs. 38.0%, p = 0.06). Future studies of DVT in CKD patients should explore novel strategies for improving prophylaxis utilization and the detection of DVT in this special population. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/18521505/Deep_vein_thrombosis_in_patients_with_chronic_kidney_disease_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1160/TH08-02-0107 DB - PRIME DP - Unbound Medicine ER -