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Changes in predictors and status of homocysteine in young male adults after a dietary intervention with vegetables, fruits and bread.
Eur J Nutr 2008; 47(4):201-9EJ

Abstract

BACKGROUND

Elevated plasma total homocysteine (p-tHcy) is associated with increased risk of cardiovascular disease, and an inverse association has been shown between the dietary intake of B-vitamins, B-vitamin profile and the concentration of p-tHcy.

AIM OF THE STUDY

The main objective of this investigation was to study the effect of a dietary intervention focusing on an increased intake of vegetables, fruits and bread. The effect of the dietary intervention was determined by the changes in plasma concentrations of tHcy, cysteine (cys), riboflavin, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) and serum concentrations of folate and vitamin B(12).

METHOD

An intervention study with duration of 5 months, including 541 male recruits from the Norwegian National Guard, Vaernes and a control group, including 209 male recruits from the Norwegian Army, Heggelia.

RESULTS

The dietary intervention resulted in decreased concentration of p-tHcy (-10%, P = 0.002), p-cys (-6%, P < 0.001) and FMN (-11%, P = 0.310) and increased concentration of riboflavin (+23%, P < 0.001) and FAD (+10%, P = 0.008) in the intervention group compared with the control group. The change in p-tHcy concentration was positively related to the change in the concentration of p-cys (P < 0.001) and FMN (P = 0.035) and inversely related to the change in concentration of folate (P = 0.021).

CONCLUSIONS

A dietary intervention program focusing on an increased intake of vegetables, fruits and bread showed a favourable effect on the concentration of p-tHcy and its metabolites. Our findings suggest that the changes in the concentration of p-cys, folate and FMN seem to be predictors of changes in the p-tHcy concentration.

Authors+Show Affiliations

Norwegian School of Hotel Management, University of Stavanger, 4036 Stavanger, Norway. tonje.h.stea@uis.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18521531

Citation

Stea, Tonje Holte, et al. "Changes in Predictors and Status of Homocysteine in Young Male Adults After a Dietary Intervention With Vegetables, Fruits and Bread." European Journal of Nutrition, vol. 47, no. 4, 2008, pp. 201-9.
Stea TH, Mansoor MA, Wandel M, et al. Changes in predictors and status of homocysteine in young male adults after a dietary intervention with vegetables, fruits and bread. Eur J Nutr. 2008;47(4):201-9.
Stea, T. H., Mansoor, M. A., Wandel, M., Uglem, S., & Frølich, W. (2008). Changes in predictors and status of homocysteine in young male adults after a dietary intervention with vegetables, fruits and bread. European Journal of Nutrition, 47(4), pp. 201-9. doi:10.1007/s00394-008-0714-y.
Stea TH, et al. Changes in Predictors and Status of Homocysteine in Young Male Adults After a Dietary Intervention With Vegetables, Fruits and Bread. Eur J Nutr. 2008;47(4):201-9. PubMed PMID: 18521531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in predictors and status of homocysteine in young male adults after a dietary intervention with vegetables, fruits and bread. AU - Stea,Tonje Holte, AU - Mansoor,Mohammad Azam, AU - Wandel,Margareta, AU - Uglem,Solveig, AU - Frølich,Wenche, Y1 - 2008/06/02/ PY - 2008/01/03/received PY - 2008/05/21/accepted PY - 2008/6/4/pubmed PY - 2008/10/24/medline PY - 2008/6/4/entrez SP - 201 EP - 9 JF - European journal of nutrition JO - Eur J Nutr VL - 47 IS - 4 N2 - BACKGROUND: Elevated plasma total homocysteine (p-tHcy) is associated with increased risk of cardiovascular disease, and an inverse association has been shown between the dietary intake of B-vitamins, B-vitamin profile and the concentration of p-tHcy. AIM OF THE STUDY: The main objective of this investigation was to study the effect of a dietary intervention focusing on an increased intake of vegetables, fruits and bread. The effect of the dietary intervention was determined by the changes in plasma concentrations of tHcy, cysteine (cys), riboflavin, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) and serum concentrations of folate and vitamin B(12). METHOD: An intervention study with duration of 5 months, including 541 male recruits from the Norwegian National Guard, Vaernes and a control group, including 209 male recruits from the Norwegian Army, Heggelia. RESULTS: The dietary intervention resulted in decreased concentration of p-tHcy (-10%, P = 0.002), p-cys (-6%, P < 0.001) and FMN (-11%, P = 0.310) and increased concentration of riboflavin (+23%, P < 0.001) and FAD (+10%, P = 0.008) in the intervention group compared with the control group. The change in p-tHcy concentration was positively related to the change in the concentration of p-cys (P < 0.001) and FMN (P = 0.035) and inversely related to the change in concentration of folate (P = 0.021). CONCLUSIONS: A dietary intervention program focusing on an increased intake of vegetables, fruits and bread showed a favourable effect on the concentration of p-tHcy and its metabolites. Our findings suggest that the changes in the concentration of p-cys, folate and FMN seem to be predictors of changes in the p-tHcy concentration. SN - 1436-6207 UR - https://www.unboundmedicine.com/medline/citation/18521531/Changes_in_predictors_and_status_of_homocysteine_in_young_male_adults_after_a_dietary_intervention_with_vegetables_fruits_and_bread_ L2 - https://dx.doi.org/10.1007/s00394-008-0714-y DB - PRIME DP - Unbound Medicine ER -