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Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness.
J Sleep Res 2008; 17(3):309-21JS

Abstract

Prolonged sleep loss impairs alertness, vigilance and some higher-order cognitive and affective capacities. Some deficits can be temporarily reversed by stimulant medications including caffeine, dextroamphetamine, and modafinil. To date, only one study has directly compared the effectiveness of these three compounds and specified the doses at which all were equally effective in restoring alertness and vigilance following 64 h of wakefulness. The present study compared the effectiveness of these same three stimulants/doses following a less extreme period of sleep loss (i.e., 44 h). Fifty-three healthy adults received a single dose of modafinil 400 mg (n = 11), dextroamphetamine 20 mg (n = 16), caffeine 600 mg (n = 12), or placebo (n = 14) after 44 h of continuous wakefulness. After 61 h of being awake, participants obtained 12 h of recovery sleep. Psychomotor vigilance was assessed bi-hourly during waking and following recovery sleep. Relative to placebo, all three stimulants were equally effective in restoring psychomotor vigilance test speed and reducing lapses, although the duration of action was shortest for caffeine and longest for dextroamphetamine. At these doses, caffeine was associated with the highest percentage of subjectively reported side-effects while modafinil did not differ significantly from placebo. Subsequent recovery sleep was adversely affected in the dextroamphetamine group, but none of the stimulants had deleterious effects on postrecovery performance. Decisions regarding stimulant selection should be made with consideration of how factors such as duration of action, potential side-effects, and subsequent disruption of recovery sleep may interact with the demands of a particular operational environment.

Authors+Show Affiliations

Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD, USA. killgore@mclean.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18522689

Citation

Killgore, William D S., et al. "Effects of Dextroamphetamine, Caffeine and Modafinil On Psychomotor Vigilance Test Performance After 44 H of Continuous Wakefulness." Journal of Sleep Research, vol. 17, no. 3, 2008, pp. 309-21.
Killgore WD, Rupp TL, Grugle NL, et al. Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness. J Sleep Res. 2008;17(3):309-21.
Killgore, W. D., Rupp, T. L., Grugle, N. L., Reichardt, R. M., Lipizzi, E. L., & Balkin, T. J. (2008). Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness. Journal of Sleep Research, 17(3), pp. 309-21. doi:10.1111/j.1365-2869.2008.00654.x.
Killgore WD, et al. Effects of Dextroamphetamine, Caffeine and Modafinil On Psychomotor Vigilance Test Performance After 44 H of Continuous Wakefulness. J Sleep Res. 2008;17(3):309-21. PubMed PMID: 18522689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness. AU - Killgore,William D S, AU - Rupp,Tracy L, AU - Grugle,Nancy L, AU - Reichardt,Rebecca M, AU - Lipizzi,Erica L, AU - Balkin,Thomas J, Y1 - 2008/06/02/ PY - 2008/6/5/pubmed PY - 2009/2/28/medline PY - 2008/6/5/entrez SP - 309 EP - 21 JF - Journal of sleep research JO - J Sleep Res VL - 17 IS - 3 N2 - Prolonged sleep loss impairs alertness, vigilance and some higher-order cognitive and affective capacities. Some deficits can be temporarily reversed by stimulant medications including caffeine, dextroamphetamine, and modafinil. To date, only one study has directly compared the effectiveness of these three compounds and specified the doses at which all were equally effective in restoring alertness and vigilance following 64 h of wakefulness. The present study compared the effectiveness of these same three stimulants/doses following a less extreme period of sleep loss (i.e., 44 h). Fifty-three healthy adults received a single dose of modafinil 400 mg (n = 11), dextroamphetamine 20 mg (n = 16), caffeine 600 mg (n = 12), or placebo (n = 14) after 44 h of continuous wakefulness. After 61 h of being awake, participants obtained 12 h of recovery sleep. Psychomotor vigilance was assessed bi-hourly during waking and following recovery sleep. Relative to placebo, all three stimulants were equally effective in restoring psychomotor vigilance test speed and reducing lapses, although the duration of action was shortest for caffeine and longest for dextroamphetamine. At these doses, caffeine was associated with the highest percentage of subjectively reported side-effects while modafinil did not differ significantly from placebo. Subsequent recovery sleep was adversely affected in the dextroamphetamine group, but none of the stimulants had deleterious effects on postrecovery performance. Decisions regarding stimulant selection should be made with consideration of how factors such as duration of action, potential side-effects, and subsequent disruption of recovery sleep may interact with the demands of a particular operational environment. SN - 1365-2869 UR - https://www.unboundmedicine.com/medline/citation/18522689/Effects_of_dextroamphetamine_caffeine_and_modafinil_on_psychomotor_vigilance_test_performance_after_44_h_of_continuous_wakefulness_ L2 - https://doi.org/10.1111/j.1365-2869.2008.00654.x DB - PRIME DP - Unbound Medicine ER -