TY - JOUR T1 - Significance of isolated positive IgM serologic results by enzyme immunoassay for coccidioidomycosis. AU - Blair,Janis E, AU - Currier,Jeremiah T, Y1 - 2008/06/04/ PY - 2007/11/07/received PY - 2008/04/22/accepted PY - 2008/6/5/pubmed PY - 2008/10/1/medline PY - 2008/6/5/entrez SP - 77 EP - 82 JF - Mycopathologia JO - Mycopathologia VL - 166 IS - 2 N2 - Serologic testing is important for diagnosis of coccidioidomycosis. Many methods are available for diagnostic testing. Enzyme immunoassay (EIA) can be performed quickly and locally but has the potential for false-positive results in patients manifesting a positive EIA for immunoglobulin M (IgM) antibodies and a negative EIA for immunoglobulin G (IgG). We retrospectively reviewed the charts of 405 patients with coccidioidal serologic testing performed between 1999 and 2003. Of 706 EIAs, 37 (5%) produced test results for 28 patients that showed isolated IgM positivity. Among these 28 patients, 24 (86%) had positive serologic findings by other methods (complement fixation or immunodiffusion or both), and 7 (25%) had positive microbiologic or histopathologic findings. All 4 (14%) patients without other positive serologic results had diagnostic tests with positive microbiologic or histopathologic results. No false-positive IgM assays were observed. We conclude that the false-positive rate of the EIA IgM is low, and that an isolated positive EIA IgM should prompt further follow-up and diagnostic testing. SN - 0301-486X UR - https://www.unboundmedicine.com/medline/citation/18523863/Significance_of_isolated_positive_IgM_serologic_results_by_enzyme_immunoassay_for_coccidioidomycosis_ L2 - https://doi.org/10.1007/s11046-008-9129-9 DB - PRIME DP - Unbound Medicine ER -