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Relationship between metabolic syndrome and its components with coronary heart disease in Iranian men and women.
Exp Clin Endocrinol Diabetes. 2008 Oct; 116(9):525-31.EC

Abstract

INTRODUCTION

Although metabolic syndrome (MetS) is receiving increased attention from physicians, data on the syndrome's association with coronary heart disease (CHD) in Iranian populations are limited.

MATERIALS AND METHODS

To estimate the odds ratio (OR) of MetS defined by each of the International Diabetes Federation (IDF), the Adult Treatment Panel (ATPIII) and the WHO definitions for CHD, logistic regression analysis was used on 5981 subjects aged > or = 30 years, in both sexes in 3 models; model 1 an age adjusted model, model 2 adjusted for age, smoking status, premature history of CHD and LDL cholesterol and model 3 adjusted for mentioned variables plus the MetS components.

RESULTS

The MetS defined by all the three definitions was associated with CHD in models 1 and 2.The relatively highest odds ratio (95% CI) of the MetS for CHD was defined in model 2 by WHO definition in men (2.3 (1.8-3)) and the ATPIII definition in women (1.6 (1.3-2)). In model 3, MetS lost its association with CHD; in men however, high fasting plasma glucose and high blood pressure (plus obesity by the WHO definition) and in women, high blood pressure (plus high waist circumference by the ATPIII, obesity and glucose domain by the WHO definition) remained associated with CHD.

CONCLUSIONS

In Iranian men and women, all three definitions of MetS were associated with CHD when considering the conventional risk factors. After further adjusting MetS components, none of these definitions showed association with CHD and only high blood pressure remained related to CHD in both sexes in all definitions.

Authors+Show Affiliations

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Science, Shahid Beheshti University (M. C), Tehran, I. R. Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18523915

Citation

Zabetian, A, et al. "Relationship Between Metabolic Syndrome and Its Components With Coronary Heart Disease in Iranian Men and Women." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 116, no. 9, 2008, pp. 525-31.
Zabetian A, Hadaegh F, Azizi F. Relationship between metabolic syndrome and its components with coronary heart disease in Iranian men and women. Exp Clin Endocrinol Diabetes. 2008;116(9):525-31.
Zabetian, A., Hadaegh, F., & Azizi, F. (2008). Relationship between metabolic syndrome and its components with coronary heart disease in Iranian men and women. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 116(9), 525-31. https://doi.org/10.1055/s-2008-1065332
Zabetian A, Hadaegh F, Azizi F. Relationship Between Metabolic Syndrome and Its Components With Coronary Heart Disease in Iranian Men and Women. Exp Clin Endocrinol Diabetes. 2008;116(9):525-31. PubMed PMID: 18523915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between metabolic syndrome and its components with coronary heart disease in Iranian men and women. AU - Zabetian,A, AU - Hadaegh,F, AU - Azizi,F, Y1 - 2008/04/01/ PY - 2008/6/5/pubmed PY - 2009/6/20/medline PY - 2008/6/5/entrez SP - 525 EP - 31 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp Clin Endocrinol Diabetes VL - 116 IS - 9 N2 - INTRODUCTION: Although metabolic syndrome (MetS) is receiving increased attention from physicians, data on the syndrome's association with coronary heart disease (CHD) in Iranian populations are limited. MATERIALS AND METHODS: To estimate the odds ratio (OR) of MetS defined by each of the International Diabetes Federation (IDF), the Adult Treatment Panel (ATPIII) and the WHO definitions for CHD, logistic regression analysis was used on 5981 subjects aged > or = 30 years, in both sexes in 3 models; model 1 an age adjusted model, model 2 adjusted for age, smoking status, premature history of CHD and LDL cholesterol and model 3 adjusted for mentioned variables plus the MetS components. RESULTS: The MetS defined by all the three definitions was associated with CHD in models 1 and 2.The relatively highest odds ratio (95% CI) of the MetS for CHD was defined in model 2 by WHO definition in men (2.3 (1.8-3)) and the ATPIII definition in women (1.6 (1.3-2)). In model 3, MetS lost its association with CHD; in men however, high fasting plasma glucose and high blood pressure (plus obesity by the WHO definition) and in women, high blood pressure (plus high waist circumference by the ATPIII, obesity and glucose domain by the WHO definition) remained associated with CHD. CONCLUSIONS: In Iranian men and women, all three definitions of MetS were associated with CHD when considering the conventional risk factors. After further adjusting MetS components, none of these definitions showed association with CHD and only high blood pressure remained related to CHD in both sexes in all definitions. SN - 0947-7349 UR - https://www.unboundmedicine.com/medline/citation/18523915/Relationship_between_metabolic_syndrome_and_its_components_with_coronary_heart_disease_in_Iranian_men_and_women_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1065332 DB - PRIME DP - Unbound Medicine ER -