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Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats.
Food Chem Toxicol 2008; 46(8):2658-64FC

Abstract

The hepatoprotective effect of methanolic extract of the leaf of Phyllanthus amarus (P. amarus) against ethanol-induced oxidative damage was investigated in adult male Wistar albino rats. P. amarus (250 and 500 mg/kg/day) and ethanol (5 g/kg/day, 20% w/v) were administered orally to animals for 4 weeks and 3 weeks, respectively. Ethanol treatment markedly decreased the level of reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in the liver, which were significantly enhanced by P. amarus treatment. Glutathione-S transferase (GST), which was increased after chronic ethanol administration, was significantly reduced by P. amarus treatment in the liver. Also, P. amarus significantly increased the activities of hepatic alanine transaminase (ALT) and aspartate transaminase (AST) as well as alkaline phosphatase (ALP), with a concomitant marked reduction in the plasma activity of the transaminases in the ethanol-challenged rats. Lipid peroxidation level, which was increased after chronic ethanol administration, was significantly reduced in the liver by P. amarus co-treatment. Results show that P. amarus leaf extract could protect the liver against ethanol-induced oxidative damage by possibly reducing the rate of lipid peroxidation and increasing the antioxidant defence mechanism in rats.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18524448

Citation

Faremi, Toyin Y., et al. "Hepatoprotective Potentials of Phyllanthusamarus Against Ethanol-induced Oxidative Stress in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 8, 2008, pp. 2658-64.
Faremi TY, Suru SM, Fafunso MA, et al. Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats. Food Chem Toxicol. 2008;46(8):2658-64.
Faremi, T. Y., Suru, S. M., Fafunso, M. A., & Obioha, U. E. (2008). Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(8), pp. 2658-64. doi:10.1016/j.fct.2008.04.022.
Faremi TY, et al. Hepatoprotective Potentials of Phyllanthusamarus Against Ethanol-induced Oxidative Stress in Rats. Food Chem Toxicol. 2008;46(8):2658-64. PubMed PMID: 18524448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats. AU - Faremi,Toyin Y, AU - Suru,Stephen M, AU - Fafunso,Michael A, AU - Obioha,Udoka E, Y1 - 2008/04/25/ PY - 2007/07/05/received PY - 2008/04/19/revised PY - 2008/04/21/accepted PY - 2008/6/6/pubmed PY - 2008/9/16/medline PY - 2008/6/6/entrez SP - 2658 EP - 64 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 46 IS - 8 N2 - The hepatoprotective effect of methanolic extract of the leaf of Phyllanthus amarus (P. amarus) against ethanol-induced oxidative damage was investigated in adult male Wistar albino rats. P. amarus (250 and 500 mg/kg/day) and ethanol (5 g/kg/day, 20% w/v) were administered orally to animals for 4 weeks and 3 weeks, respectively. Ethanol treatment markedly decreased the level of reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in the liver, which were significantly enhanced by P. amarus treatment. Glutathione-S transferase (GST), which was increased after chronic ethanol administration, was significantly reduced by P. amarus treatment in the liver. Also, P. amarus significantly increased the activities of hepatic alanine transaminase (ALT) and aspartate transaminase (AST) as well as alkaline phosphatase (ALP), with a concomitant marked reduction in the plasma activity of the transaminases in the ethanol-challenged rats. Lipid peroxidation level, which was increased after chronic ethanol administration, was significantly reduced in the liver by P. amarus co-treatment. Results show that P. amarus leaf extract could protect the liver against ethanol-induced oxidative damage by possibly reducing the rate of lipid peroxidation and increasing the antioxidant defence mechanism in rats. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/18524448/Hepatoprotective_potentials_of_Phyllanthusamarus_against_ethanol_induced_oxidative_stress_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00207-X DB - PRIME DP - Unbound Medicine ER -