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[Statins in stroke prevention].

Abstract

Cholesterol lowering with statins has been proven to reduce vascular events in primary and secondary prevention of coronary artery disease (CAD). Epidemiologic studies found no or little association between blood cholesterol levels and stroke. However, randomized trials in patients with CAD have shown that statins decrease stroke incidence. These statin trials indicate 21% relative risk reductions for stroke. In subgroup analysis of the Heart Protection Study, simvastatin had no effect on stroke recurrence, in patients with a previous stroke. Recently, Stroke Prevention by Aggressive Reduction in Cholesterol Levels study showed that treatment with high dose atorvastatin reduced risk of stroke in patients with recent stroke and transient ischemic attack and no known CAD. In this review, we will discuss the effects of statins on stroke and the potential mechanisms of action.

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  • Authors+Show Affiliations

    ,

    Karadeniz Teknik Universitesi Tip Fakültesi, Kardiyoloji Anabilim Dali, Trabzon, Türkiye. omergedikli@yahoo.com

    Source

    MeSH

    Humans
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Ischemic Attack, Transient
    Randomized Controlled Trials as Topic

    Pub Type(s)

    English Abstract
    Journal Article
    Review

    Language

    tur

    PubMed ID

    18524729

    Citation

    Gedikli, Omer, and Merih Baykan. "[Statins in Stroke Prevention]." Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology, vol. 8, no. 3, 2008, pp. 217-22.
    Gedikli O, Baykan M. [Statins in stroke prevention]. Anadolu Kardiyol Derg. 2008;8(3):217-22.
    Gedikli, O., & Baykan, M. (2008). [Statins in stroke prevention]. Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology, 8(3), pp. 217-22.
    Gedikli O, Baykan M. [Statins in Stroke Prevention]. Anadolu Kardiyol Derg. 2008;8(3):217-22. PubMed PMID: 18524729.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Statins in stroke prevention]. AU - Gedikli,Omer, AU - Baykan,Merih, PY - 2008/6/6/pubmed PY - 2008/8/14/medline PY - 2008/6/6/entrez SP - 217 EP - 22 JF - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology JO - Anadolu Kardiyol Derg VL - 8 IS - 3 N2 - Cholesterol lowering with statins has been proven to reduce vascular events in primary and secondary prevention of coronary artery disease (CAD). Epidemiologic studies found no or little association between blood cholesterol levels and stroke. However, randomized trials in patients with CAD have shown that statins decrease stroke incidence. These statin trials indicate 21% relative risk reductions for stroke. In subgroup analysis of the Heart Protection Study, simvastatin had no effect on stroke recurrence, in patients with a previous stroke. Recently, Stroke Prevention by Aggressive Reduction in Cholesterol Levels study showed that treatment with high dose atorvastatin reduced risk of stroke in patients with recent stroke and transient ischemic attack and no known CAD. In this review, we will discuss the effects of statins on stroke and the potential mechanisms of action. SN - 1308-0032 UR - https://www.unboundmedicine.com/medline/citation/18524729/[Statins_in_stroke_prevention]_ L2 - http://www.anatoljcardiol.com/linkout/?PMID=18524729 DB - PRIME DP - Unbound Medicine ER -