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The acute effect of green tea consumption on endothelial function in healthy individuals.

Abstract

BACKGROUND

Tea consumption is associated with decreased cardiovascular risk. Flow-mediated dilatation (FMD) of the brachial artery is related to coronary endothelial function and it is an independent predictor of cardiovascular risk. Black tea has a beneficial effect on endothelial function; the effect, however, of green tea on brachial artery reactivity has not been defined yet.

DESIGN AND METHODS

We studied 14 healthy individuals (age 30+/-3 years) with no cardiovascular risk factors except from smoking (50%) on three separate occasions on which they took: (a) 6 g of green tea, (b) 125 mg of caffeine (the amount contained in 6 g of tea), or (c) hot water. FMD of the brachial artery was measured before each intervention and 30, 90, and 120 min afterward. High-sensitivity C-reactive protein, interleukins 6 (Il-6) and 1b (Il-1b), total plasma antioxidative capacity, and total plasma oxidative status/stress were measured at baseline and at 120 min after each intervention.

RESULTS

Resting and hyperemic brachial artery diameter did not change either with tea or with caffeine. FMD increased significantly with tea (by 3.69%, peak at 30 min, P<0.02), whereas it did not change significantly with caffeine (increase by 1.72%, peak at 30 min, P=NS). Neither tea nor caffeine had any effect on high-sensitivity C-reactive protein, Il-6, Il-1b, total plasma antioxidative capacity, or total plasma oxidative status/stress.

CONCLUSION

Green tea consumption has an acute beneficial effect on endothelial function, assessed with FMD of the brachial artery, in healthy individuals. This may be involved in the beneficial effect of tea on cardiovascular risk.

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  • Authors+Show Affiliations

    ,

    Peripheral Vessels Unit, First Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece.

    , , , , , , ,

    Source

    MeSH

    Adult
    Brachial Artery
    Caffeine
    Catechin
    Central Nervous System Stimulants
    Cross-Over Studies
    Drinking
    Endothelium, Vascular
    Female
    Humans
    Male
    Oxidative Stress
    Single-Blind Method
    Tea
    Vasodilation

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    18525384

    Citation

    Alexopoulos, Nikolaos, et al. "The Acute Effect of Green Tea Consumption On Endothelial Function in Healthy Individuals." European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, vol. 15, no. 3, 2008, pp. 300-5.
    Alexopoulos N, Vlachopoulos C, Aznaouridis K, et al. The acute effect of green tea consumption on endothelial function in healthy individuals. Eur J Cardiovasc Prev Rehabil. 2008;15(3):300-5.
    Alexopoulos, N., Vlachopoulos, C., Aznaouridis, K., Baou, K., Vasiliadou, C., Pietri, P., ... Stefanadis, C. (2008). The acute effect of green tea consumption on endothelial function in healthy individuals. European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 15(3), pp. 300-5. doi:10.1097/HJR.0b013e3282f4832f.
    Alexopoulos N, et al. The Acute Effect of Green Tea Consumption On Endothelial Function in Healthy Individuals. Eur J Cardiovasc Prev Rehabil. 2008;15(3):300-5. PubMed PMID: 18525384.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The acute effect of green tea consumption on endothelial function in healthy individuals. AU - Alexopoulos,Nikolaos, AU - Vlachopoulos,Charalambos, AU - Aznaouridis,Konstantinos, AU - Baou,Katerina, AU - Vasiliadou,Carmen, AU - Pietri,Panagiota, AU - Xaplanteris,Panagiotis, AU - Stefanadi,Elli, AU - Stefanadis,Christodoulos, PY - 2008/6/6/pubmed PY - 2008/11/19/medline PY - 2008/6/6/entrez SP - 300 EP - 5 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 15 IS - 3 N2 - BACKGROUND: Tea consumption is associated with decreased cardiovascular risk. Flow-mediated dilatation (FMD) of the brachial artery is related to coronary endothelial function and it is an independent predictor of cardiovascular risk. Black tea has a beneficial effect on endothelial function; the effect, however, of green tea on brachial artery reactivity has not been defined yet. DESIGN AND METHODS: We studied 14 healthy individuals (age 30+/-3 years) with no cardiovascular risk factors except from smoking (50%) on three separate occasions on which they took: (a) 6 g of green tea, (b) 125 mg of caffeine (the amount contained in 6 g of tea), or (c) hot water. FMD of the brachial artery was measured before each intervention and 30, 90, and 120 min afterward. High-sensitivity C-reactive protein, interleukins 6 (Il-6) and 1b (Il-1b), total plasma antioxidative capacity, and total plasma oxidative status/stress were measured at baseline and at 120 min after each intervention. RESULTS: Resting and hyperemic brachial artery diameter did not change either with tea or with caffeine. FMD increased significantly with tea (by 3.69%, peak at 30 min, P<0.02), whereas it did not change significantly with caffeine (increase by 1.72%, peak at 30 min, P=NS). Neither tea nor caffeine had any effect on high-sensitivity C-reactive protein, Il-6, Il-1b, total plasma antioxidative capacity, or total plasma oxidative status/stress. CONCLUSION: Green tea consumption has an acute beneficial effect on endothelial function, assessed with FMD of the brachial artery, in healthy individuals. This may be involved in the beneficial effect of tea on cardiovascular risk. SN - 1741-8267 UR - https://www.unboundmedicine.com/medline/citation/18525384/The_acute_effect_of_green_tea_consumption_on_endothelial_function_in_healthy_individuals_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=18525384.ui DB - PRIME DP - Unbound Medicine ER -