TY - JOUR T1 - Impact of whole-body imaging on treatment decision to radio-frequency ablation in patients with malignant liver tumors: comparison of [18F]fluorodeoxyglucose-PET/computed tomography, PET and computed tomography. AU - Kuehl,Hilmar, AU - Rosenbaum-Krumme,Sandra, AU - Veit-Haibach,Patrick, AU - Stergar,Hrvoje, AU - Forsting,Michael, AU - Bockisch,Andreas, AU - Antoch,Gerald, PY - 2008/6/6/pubmed PY - 2008/8/20/medline PY - 2008/6/6/entrez SP - 599 EP - 606 JF - Nuclear medicine communications JO - Nucl Med Commun VL - 29 IS - 7 N2 - OBJECTIVE: The correct staging of patients with malignant liver tumors before radio-frequency ablation (RFA) is mandatory for successful treatment. Our study aimed to compare the influence on decision to perform RFA of whole-body fluorodeoxyglucose (FDG)-PET/computed tomography (CT) with whole-body contrast-enhanced CT (CE-CT) and PET alone. METHODS: Fifty-eight patients with known hepatic malignancies (23, liver metastases 35) received FDG-PET/CT before RFA planned with curative intention. CT and PET data were each read separately, PET/CT fusion data were read in consensus afterward by a third reader group. The diagnostic accuracy of CE-CT, PET alone, and PET/CT to identify patients eligible for RFA was compared and the impact on decision was analyzed. The McNemar test with Bonferroni correction was used to test for significant differences. RESULTS: The accuracy and sensitivity to detect correctly intrahepatic and extrahepatic tumor were 94 and 97% for CT, 75 and 54% for PET, and 97 and 95% for PET/CT. The differences between CT and PET, as well as between PET/CT and PET, were statistically significant, but there was no significant difference between PET/CT and CT alone (P>0.65). PET alone, CE-CT, and PET/CT correctly identified 32, 55, and 57 patients, respectively. Again, PET/CT showed no significant advantage over CE-CT. Both imaging methods performed significantly better than PET alone (P<0.0001). Forty-three (74%) of 58 patients underwent RFA with curative intention. CONCLUSION: Whole-body imaging changed patient management in 26% of the patients planned for curative intended RFA, yet there was no significant difference between CE-CT and PET/CT. SN - 0143-3636 UR - https://www.unboundmedicine.com/medline/citation/18528181/Impact_of_whole_body_imaging_on_treatment_decision_to_radio_frequency_ablation_in_patients_with_malignant_liver_tumors:_comparison_of_[18F]fluorodeoxyglucose_PET/computed_tomography_PET_and_computed_tomography_ L2 - https://doi.org/10.1097/MNM.0b013e3282f8144d DB - PRIME DP - Unbound Medicine ER -