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Circulating cytokine levels compared to pain in patients with fibromyalgia -- a prospective longitudinal study over 6 months.
J Rheumatol 2008; 35(7):1366-70JR

Abstract

OBJECTIVE

This prospective study examined circulating cytokines in patients with fibromyalgia (FM) over 6 months rather than at only one timepoint, and investigated correlations between serum cytokine concentrations and pain intensity in FM patients receiving multidisciplinary pain therapy.

METHODS

Serum concentrations of proinflammatory cytokines interleukin 6 (IL-6), IL-8, and tumor necrosis factor-alpha (TNF-alpha) and antiinflammatory cytokines IL-4 and IL-10 were measured (Bio-Plex system) in 20 FM patients and 80 healthy subjects on admission and 10, 21, and 180 days after initiation of treatment and correlated to pain intensity.

RESULTS

On admission, serum levels of IL-8 (p < 0.001) and TNF-alpha (p < 0.001), but not IL-6, were elevated in patients with FM. No significant difference in IL-4 and IL-10 was found between FM patients and controls. High IL-8 levels remained consistent during the followup, but TNF-alpha was already reduced after 10 days and until 6 months after therapy. After 6 months' treatment with multidisciplinary pain therapy, IL-8 and TNF-alpha levels were significantly lower than at the beginning (p < 0.05 for IL-8, p < 0.001 for TNF-alpha). IL-8 but not TNF-alpha serum levels were correlated with pain intensity (r = -0.782, p = 0.001) in FM patients after 6 months' multidisciplinary pain therapy.

CONCLUSION

Our results suggest that proinflammatory cytokines TNF-alpha and IL-8 are involved in FM, but they do not apparently provoke the pain of FM directly. Multidisciplinary pain therapy modified the cytokine profile in patients with FM during the observation period.

Authors+Show Affiliations

Department of Orthopaedic Surgery, Ruprecht-Karls-University of Heidelberg, Heidelberg; and SRH Klinikum Karlsbad-Langensteinbach, Karlsbad, Germany. haili.wang@ok.uni-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18528959

Citation

Wang, Haili, et al. "Circulating Cytokine Levels Compared to Pain in Patients With Fibromyalgia -- a Prospective Longitudinal Study Over 6 Months." The Journal of Rheumatology, vol. 35, no. 7, 2008, pp. 1366-70.
Wang H, Moser M, Schiltenwolf M, et al. Circulating cytokine levels compared to pain in patients with fibromyalgia -- a prospective longitudinal study over 6 months. J Rheumatol. 2008;35(7):1366-70.
Wang, H., Moser, M., Schiltenwolf, M., & Buchner, M. (2008). Circulating cytokine levels compared to pain in patients with fibromyalgia -- a prospective longitudinal study over 6 months. The Journal of Rheumatology, 35(7), pp. 1366-70.
Wang H, et al. Circulating Cytokine Levels Compared to Pain in Patients With Fibromyalgia -- a Prospective Longitudinal Study Over 6 Months. J Rheumatol. 2008;35(7):1366-70. PubMed PMID: 18528959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating cytokine levels compared to pain in patients with fibromyalgia -- a prospective longitudinal study over 6 months. AU - Wang,Haili, AU - Moser,Michael, AU - Schiltenwolf,Marcus, AU - Buchner,Matthias, Y1 - 2008/06/01/ PY - 2008/6/6/pubmed PY - 2008/12/17/medline PY - 2008/6/6/entrez SP - 1366 EP - 70 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 35 IS - 7 N2 - OBJECTIVE: This prospective study examined circulating cytokines in patients with fibromyalgia (FM) over 6 months rather than at only one timepoint, and investigated correlations between serum cytokine concentrations and pain intensity in FM patients receiving multidisciplinary pain therapy. METHODS: Serum concentrations of proinflammatory cytokines interleukin 6 (IL-6), IL-8, and tumor necrosis factor-alpha (TNF-alpha) and antiinflammatory cytokines IL-4 and IL-10 were measured (Bio-Plex system) in 20 FM patients and 80 healthy subjects on admission and 10, 21, and 180 days after initiation of treatment and correlated to pain intensity. RESULTS: On admission, serum levels of IL-8 (p < 0.001) and TNF-alpha (p < 0.001), but not IL-6, were elevated in patients with FM. No significant difference in IL-4 and IL-10 was found between FM patients and controls. High IL-8 levels remained consistent during the followup, but TNF-alpha was already reduced after 10 days and until 6 months after therapy. After 6 months' treatment with multidisciplinary pain therapy, IL-8 and TNF-alpha levels were significantly lower than at the beginning (p < 0.05 for IL-8, p < 0.001 for TNF-alpha). IL-8 but not TNF-alpha serum levels were correlated with pain intensity (r = -0.782, p = 0.001) in FM patients after 6 months' multidisciplinary pain therapy. CONCLUSION: Our results suggest that proinflammatory cytokines TNF-alpha and IL-8 are involved in FM, but they do not apparently provoke the pain of FM directly. Multidisciplinary pain therapy modified the cytokine profile in patients with FM during the observation period. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/18528959/Circulating_cytokine_levels_compared_to_pain_in_patients_with_fibromyalgia____a_prospective_longitudinal_study_over_6_months_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=18528959 DB - PRIME DP - Unbound Medicine ER -