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N-Terminal pro B-type natriuretic peptide testing for short-term prognosis in breathless older adults.
Am J Emerg Med 2008; 26(5):555-60AJ

Abstract

BACKGROUND

Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful for the triage of patients with dyspnea. Our aim was to determine whether NT-proBNP levels could predict in-hospital outcome in breathless elderly patients.

METHODS

At admission, NT-proBNP plasma concentrations were determined in 324 dyspneic patients aged 75 years and older. The association between NT-proBNP values and in-hospital mortality was assessed.

RESULTS

Median NT-proBNP concentrations were not different in deceased patients (n = 43, 13%) compared to that of survivors (n = 281, 87%) (4354 vs 2499 pg/mL, respectively; P = .06). To predict in-hospital mortality, the optimum threshold of NT-proBNP was 3855 pg/mL, as defined by the receiver operating characteristic (ROC) curve, with a nonsignificant area under the ROC curve of 0.59. Mortality was significantly higher in patients (n = 139) with NT-proBNP levels 3855 pg/mL or higher (17.9% vs 9.7%, P = .045). After multivariate analysis, NT-proBNP level 3855 pg/mL or higher at admission was predictive of mortality (odds ratio, 2.41; 95% confidence interval, 1.02-5.68; P = .04).

CONCLUSION

NT-proBNP higher than 3855 pg/mL is associated with in-hospital mortality in patients aged 75 years and older admitted for dyspnea.

Authors+Show Affiliations

Department of Biochemistry A, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18534284

Citation

Chenevier-Gobeaux, Camille, et al. "N-Terminal Pro B-type Natriuretic Peptide Testing for Short-term Prognosis in Breathless Older Adults." The American Journal of Emergency Medicine, vol. 26, no. 5, 2008, pp. 555-60.
Chenevier-Gobeaux C, Allo JC, Arthaud M, et al. N-Terminal pro B-type natriuretic peptide testing for short-term prognosis in breathless older adults. Am J Emerg Med. 2008;26(5):555-60.
Chenevier-Gobeaux, C., Allo, J. C., Arthaud, M., Achkar, R., Claessens, Y. E., Ekindjian, O. G., ... Ray, P. (2008). N-Terminal pro B-type natriuretic peptide testing for short-term prognosis in breathless older adults. The American Journal of Emergency Medicine, 26(5), pp. 555-60. doi:10.1016/j.ajem.2007.08.027.
Chenevier-Gobeaux C, et al. N-Terminal Pro B-type Natriuretic Peptide Testing for Short-term Prognosis in Breathless Older Adults. Am J Emerg Med. 2008;26(5):555-60. PubMed PMID: 18534284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - N-Terminal pro B-type natriuretic peptide testing for short-term prognosis in breathless older adults. AU - Chenevier-Gobeaux,Camille, AU - Allo,Jean-Christophe, AU - Arthaud,Martine, AU - Achkar,R, AU - Claessens,Yan-Eric, AU - Ekindjian,O G, AU - Riou,Bruno, AU - Ray,Patrick, PY - 2007/04/18/received PY - 2007/08/23/revised PY - 2007/08/23/accepted PY - 2008/6/7/pubmed PY - 2008/7/2/medline PY - 2008/6/7/entrez SP - 555 EP - 60 JF - The American journal of emergency medicine JO - Am J Emerg Med VL - 26 IS - 5 N2 - BACKGROUND: Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful for the triage of patients with dyspnea. Our aim was to determine whether NT-proBNP levels could predict in-hospital outcome in breathless elderly patients. METHODS: At admission, NT-proBNP plasma concentrations were determined in 324 dyspneic patients aged 75 years and older. The association between NT-proBNP values and in-hospital mortality was assessed. RESULTS: Median NT-proBNP concentrations were not different in deceased patients (n = 43, 13%) compared to that of survivors (n = 281, 87%) (4354 vs 2499 pg/mL, respectively; P = .06). To predict in-hospital mortality, the optimum threshold of NT-proBNP was 3855 pg/mL, as defined by the receiver operating characteristic (ROC) curve, with a nonsignificant area under the ROC curve of 0.59. Mortality was significantly higher in patients (n = 139) with NT-proBNP levels 3855 pg/mL or higher (17.9% vs 9.7%, P = .045). After multivariate analysis, NT-proBNP level 3855 pg/mL or higher at admission was predictive of mortality (odds ratio, 2.41; 95% confidence interval, 1.02-5.68; P = .04). CONCLUSION: NT-proBNP higher than 3855 pg/mL is associated with in-hospital mortality in patients aged 75 years and older admitted for dyspnea. SN - 1532-8171 UR - https://www.unboundmedicine.com/medline/citation/18534284/N_Terminal_pro_B_type_natriuretic_peptide_testing_for_short_term_prognosis_in_breathless_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-6757(07)00547-5 DB - PRIME DP - Unbound Medicine ER -