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Effect of peripartum dietary energy supplementation of dairy cows on metabolites, liver function and reproductive variables.
Anim Reprod Sci. 2009 Jun; 112(3-4):301-15.AR

Abstract

Multiparous Holstein cows (n=58) were used to study the effects of peripartum dietary supplementation on metabolic status, liver function and reproduction variables. Diets for cows were as follows: (a) no supplementation (CTL), (b) prilled fatty acids as 1.9% of DM (PrFA), (c) calcium salts of long chain n-6 fatty acids as 2.24% of DM (CaLFA) or (d) daily topdressing with 769 g of 65% propylene glycol (PGLY). Supplements were fed during the last 21 days before expected calving except for PGLY that continued until 21 days after parturition. Ovarian activity was monitored by transrectal ultrasonography and days to first ovulation were recorded. Liver biopsies were obtained on day 8 and 21 postpartum and analyzed for triglyceride content and mRNA expression of pyruvate carboxylase, cytosolic phosphoenolpyruvate carboxykinase, carnitine palmytoyltransferase 1A, and peroxisome proliferator-activated receptor-alpha. At 71 days following parturition, stage of ovarian cycles was synchronized and at day15 of the cycle oxytocin was injected i.v., blood samples were obtained at frequent intervals, and analyzed for 13,14 dihydro, 15-keto PGF(2alpha) (PGFM). Milk production and milk components were not different among treatment groups. Cows in PGLY gained body condition score (BCS) prepartum and net energy balance prepartum tended to be greater, but was not different postpartum from other groups. PGLY supplementation increased plasma insulin concentration prepartum, but not during the postpartum period. No significant differences were observed in plasma concentrations of glucose, NEFA, and insulin-like growth factor or hepatic triglyceride content, but all supplements tended to decrease beta hydroxybutyrate postpartum compared to CTL cows. Abundance of mRNA of gluconeogenic and lipid oxidation genes was not different among treatment groups. Days to first ovulation and uterine PGF(2alpha) production in response to an oxytocin treatment were not significantly different among treatment groups. Peripartum supplementation did not result in the substantial improvement of metabolic profile in early lactation nor significantly affect days to first ovulation and PGFM response to an oxytocin treatment.

Authors+Show Affiliations

Department of Animal Science, Cornell University, Ithaca, NY 14853, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18534791

Citation

Castañeda-Gutiérrez, E, et al. "Effect of Peripartum Dietary Energy Supplementation of Dairy Cows On Metabolites, Liver Function and Reproductive Variables." Animal Reproduction Science, vol. 112, no. 3-4, 2009, pp. 301-15.
Castañeda-Gutiérrez E, Pelton SH, Gilbert RO, et al. Effect of peripartum dietary energy supplementation of dairy cows on metabolites, liver function and reproductive variables. Anim Reprod Sci. 2009;112(3-4):301-15.
Castañeda-Gutiérrez, E., Pelton, S. H., Gilbert, R. O., & Butler, W. R. (2009). Effect of peripartum dietary energy supplementation of dairy cows on metabolites, liver function and reproductive variables. Animal Reproduction Science, 112(3-4), 301-15. https://doi.org/10.1016/j.anireprosci.2008.04.028
Castañeda-Gutiérrez E, et al. Effect of Peripartum Dietary Energy Supplementation of Dairy Cows On Metabolites, Liver Function and Reproductive Variables. Anim Reprod Sci. 2009;112(3-4):301-15. PubMed PMID: 18534791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of peripartum dietary energy supplementation of dairy cows on metabolites, liver function and reproductive variables. AU - Castañeda-Gutiérrez,E, AU - Pelton,S H, AU - Gilbert,R O, AU - Butler,W R, Y1 - 2008/05/03/ PY - 2008/01/10/received PY - 2008/04/06/revised PY - 2008/04/28/accepted PY - 2008/6/7/pubmed PY - 2009/6/23/medline PY - 2008/6/7/entrez SP - 301 EP - 15 JF - Animal reproduction science JO - Anim Reprod Sci VL - 112 IS - 3-4 N2 - Multiparous Holstein cows (n=58) were used to study the effects of peripartum dietary supplementation on metabolic status, liver function and reproduction variables. Diets for cows were as follows: (a) no supplementation (CTL), (b) prilled fatty acids as 1.9% of DM (PrFA), (c) calcium salts of long chain n-6 fatty acids as 2.24% of DM (CaLFA) or (d) daily topdressing with 769 g of 65% propylene glycol (PGLY). Supplements were fed during the last 21 days before expected calving except for PGLY that continued until 21 days after parturition. Ovarian activity was monitored by transrectal ultrasonography and days to first ovulation were recorded. Liver biopsies were obtained on day 8 and 21 postpartum and analyzed for triglyceride content and mRNA expression of pyruvate carboxylase, cytosolic phosphoenolpyruvate carboxykinase, carnitine palmytoyltransferase 1A, and peroxisome proliferator-activated receptor-alpha. At 71 days following parturition, stage of ovarian cycles was synchronized and at day15 of the cycle oxytocin was injected i.v., blood samples were obtained at frequent intervals, and analyzed for 13,14 dihydro, 15-keto PGF(2alpha) (PGFM). Milk production and milk components were not different among treatment groups. Cows in PGLY gained body condition score (BCS) prepartum and net energy balance prepartum tended to be greater, but was not different postpartum from other groups. PGLY supplementation increased plasma insulin concentration prepartum, but not during the postpartum period. No significant differences were observed in plasma concentrations of glucose, NEFA, and insulin-like growth factor or hepatic triglyceride content, but all supplements tended to decrease beta hydroxybutyrate postpartum compared to CTL cows. Abundance of mRNA of gluconeogenic and lipid oxidation genes was not different among treatment groups. Days to first ovulation and uterine PGF(2alpha) production in response to an oxytocin treatment were not significantly different among treatment groups. Peripartum supplementation did not result in the substantial improvement of metabolic profile in early lactation nor significantly affect days to first ovulation and PGFM response to an oxytocin treatment. SN - 1873-2232 UR - https://www.unboundmedicine.com/medline/citation/18534791/Effect_of_peripartum_dietary_energy_supplementation_of_dairy_cows_on_metabolites_liver_function_and_reproductive_variables_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-4320(08)00156-5 DB - PRIME DP - Unbound Medicine ER -