Tags

Type your tag names separated by a space and hit enter

The incidence of contact lens-related microbial keratitis in Australia.
Ophthalmology. 2008 Oct; 115(10):1655-62.O

Abstract

OBJECTIVE

To establish the absolute risk of contact lens (CL)-related microbial keratitis, the incidence of vision loss and risk factors for disease.

DESIGN

A prospective, 12-month, population-based surveillance study.

PARTICIPANTS

New cases of CL-related microbial keratitis presenting in Australia over a 12-month period were identified through surveillance of all ophthalmic practitioners (numerator). Case detection was augmented by records' audits at major ophthalmic centers. The denominator (number of wearers of different CL types in the community) was established using a national telephone survey of 35,914 individuals.

TESTING

Cases and controls were interviewed by telephone to determine subject demographics and CL wear history. Visual outcomes were determined 6 months after the initial event. Annualized incidence and confidence intervals (CI) were estimated for different severities of disease and multivariable analysis was used in risk factor analysis.

MAIN OUTCOME MEASURES

Annualized incidence (with CI) of disease and vision loss by CL type and wear modality and identification of independent risk factors.

RESULTS

We identified 285 eligible cases of CL-related microbial keratitis and 1798 controls. In daily wear rigid gas-permeable CL wearers, the annualized incidence per 10,000 wearers was 1.2 (CI, 1.1-1.5); in daily wear soft CL wearers 1.9 (CI, 1.8-2.0); soft CL wearers (occasional overnight use) 2.2 (CI, 2.0-2.5); daily disposable CL wearers 2.0 (CI, 1.7-2.4); daily disposable CL wearers (occasional overnight use) 4.2 (CI, 3.1-6.6); daily wear silicone hydrogel CL wearers 11.9 (CI, 10.0-14.6); silicone hydrogel CL wearers (occasional overnight use) 5.5 (CI, 4.5-7.2); overnight wear soft CL wearers 19.5 (CI, 14.6-29.5) and in overnight wear of silicone hydrogel 25.4 (CI, 21.2-31.5). Loss of vision occurred in 0.6 per 10,000 wearers. Risk factors included overnight use, poor storage case hygiene, smoking, Internet purchase of CLs, <6 months wear experience, and higher socioeconomic class.

CONCLUSIONS

Incidence estimates for soft CL use were similar to those previously reported. New lens types have not reduced the incidence of disease. Overnight use of any CL is associated with a higher risk than daily use.

Authors+Show Affiliations

Institute for Eye Research, Sydney, Australia. F.Stapleton@unsw.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18538404

Citation

Stapleton, Fiona, et al. "The Incidence of Contact Lens-related Microbial Keratitis in Australia." Ophthalmology, vol. 115, no. 10, 2008, pp. 1655-62.
Stapleton F, Keay L, Edwards K, et al. The incidence of contact lens-related microbial keratitis in Australia. Ophthalmology. 2008;115(10):1655-62.
Stapleton, F., Keay, L., Edwards, K., Naduvilath, T., Dart, J. K., Brian, G., & Holden, B. A. (2008). The incidence of contact lens-related microbial keratitis in Australia. Ophthalmology, 115(10), 1655-62. https://doi.org/10.1016/j.ophtha.2008.04.002
Stapleton F, et al. The Incidence of Contact Lens-related Microbial Keratitis in Australia. Ophthalmology. 2008;115(10):1655-62. PubMed PMID: 18538404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The incidence of contact lens-related microbial keratitis in Australia. AU - Stapleton,Fiona, AU - Keay,Lisa, AU - Edwards,Katie, AU - Naduvilath,Thomas, AU - Dart,John K G, AU - Brian,Garry, AU - Holden,Brien A, Y1 - 2008/06/05/ PY - 2007/11/06/received PY - 2008/03/24/revised PY - 2008/04/01/accepted PY - 2008/6/10/pubmed PY - 2008/10/31/medline PY - 2008/6/10/entrez SP - 1655 EP - 62 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 10 N2 - OBJECTIVE: To establish the absolute risk of contact lens (CL)-related microbial keratitis, the incidence of vision loss and risk factors for disease. DESIGN: A prospective, 12-month, population-based surveillance study. PARTICIPANTS: New cases of CL-related microbial keratitis presenting in Australia over a 12-month period were identified through surveillance of all ophthalmic practitioners (numerator). Case detection was augmented by records' audits at major ophthalmic centers. The denominator (number of wearers of different CL types in the community) was established using a national telephone survey of 35,914 individuals. TESTING: Cases and controls were interviewed by telephone to determine subject demographics and CL wear history. Visual outcomes were determined 6 months after the initial event. Annualized incidence and confidence intervals (CI) were estimated for different severities of disease and multivariable analysis was used in risk factor analysis. MAIN OUTCOME MEASURES: Annualized incidence (with CI) of disease and vision loss by CL type and wear modality and identification of independent risk factors. RESULTS: We identified 285 eligible cases of CL-related microbial keratitis and 1798 controls. In daily wear rigid gas-permeable CL wearers, the annualized incidence per 10,000 wearers was 1.2 (CI, 1.1-1.5); in daily wear soft CL wearers 1.9 (CI, 1.8-2.0); soft CL wearers (occasional overnight use) 2.2 (CI, 2.0-2.5); daily disposable CL wearers 2.0 (CI, 1.7-2.4); daily disposable CL wearers (occasional overnight use) 4.2 (CI, 3.1-6.6); daily wear silicone hydrogel CL wearers 11.9 (CI, 10.0-14.6); silicone hydrogel CL wearers (occasional overnight use) 5.5 (CI, 4.5-7.2); overnight wear soft CL wearers 19.5 (CI, 14.6-29.5) and in overnight wear of silicone hydrogel 25.4 (CI, 21.2-31.5). Loss of vision occurred in 0.6 per 10,000 wearers. Risk factors included overnight use, poor storage case hygiene, smoking, Internet purchase of CLs, <6 months wear experience, and higher socioeconomic class. CONCLUSIONS: Incidence estimates for soft CL use were similar to those previously reported. New lens types have not reduced the incidence of disease. Overnight use of any CL is associated with a higher risk than daily use. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/18538404/The_incidence_of_contact_lens_related_microbial_keratitis_in_Australia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(08)00307-2 DB - PRIME DP - Unbound Medicine ER -