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Effects of subacute exposure of dichlorvos at sublethal dosages on erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats.
Ecotoxicol Environ Saf. 2009 Mar; 72(3):905-8.EE

Abstract

In this study, the effects of dichlorvos (DIC) at sublethal concentration on malondialdehyde (MDA) content and antioxidant defense system (ADS) such as reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), and glutathione-S-transferase (GST) in various tissues of rats exposed to 0.0225 and 0.0450 millimole (mmol) DIC in drinking water were administered orally to rats ad libitum for 28 days continuously. MDA significantly increased in all the tissues except in the lungs of rats treated with both dosages of DIC. With regard to the ADS, GR significantly decreased in the erythrocytes whereas it did not change in the other tissues with two dosages of DIC. SOD activity significantly increased in the all tissues treated with both dosages of DIC. GST activity significantly increased in all the tissues except in the erythrocytes, spleen, and lungs treated with 0.0225mmol. Meanwhile, GSH depletion in the liver and heart of rats treated with 0.0225mmol and all the tissues except in the brain and kidney of rats treated with 0.0450mmol of DIC were found to be significant. The observations presented led us to conclude that the administrations of DIC promote MDA content and fluctuate in the ADS in rats during the exposure.

Authors+Show Affiliations

Department of Biology, Science and Lettes Faculty, Yuzuncu Yil University, 65080 Van, Turkey.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18539328

Citation

Celik, Ismail, and Huseyin Suzek. "Effects of Subacute Exposure of Dichlorvos at Sublethal Dosages On Erythrocyte and Tissue Antioxidant Defense Systems and Lipid Peroxidation in Rats." Ecotoxicology and Environmental Safety, vol. 72, no. 3, 2009, pp. 905-8.
Celik I, Suzek H. Effects of subacute exposure of dichlorvos at sublethal dosages on erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. Ecotoxicol Environ Saf. 2009;72(3):905-8.
Celik, I., & Suzek, H. (2009). Effects of subacute exposure of dichlorvos at sublethal dosages on erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. Ecotoxicology and Environmental Safety, 72(3), 905-8. https://doi.org/10.1016/j.ecoenv.2008.04.007
Celik I, Suzek H. Effects of Subacute Exposure of Dichlorvos at Sublethal Dosages On Erythrocyte and Tissue Antioxidant Defense Systems and Lipid Peroxidation in Rats. Ecotoxicol Environ Saf. 2009;72(3):905-8. PubMed PMID: 18539328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of subacute exposure of dichlorvos at sublethal dosages on erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. AU - Celik,Ismail, AU - Suzek,Huseyin, Y1 - 2008/06/09/ PY - 2007/12/17/received PY - 2008/04/01/revised PY - 2008/04/05/accepted PY - 2008/6/10/pubmed PY - 2009/5/8/medline PY - 2008/6/10/entrez SP - 905 EP - 8 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 72 IS - 3 N2 - In this study, the effects of dichlorvos (DIC) at sublethal concentration on malondialdehyde (MDA) content and antioxidant defense system (ADS) such as reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), and glutathione-S-transferase (GST) in various tissues of rats exposed to 0.0225 and 0.0450 millimole (mmol) DIC in drinking water were administered orally to rats ad libitum for 28 days continuously. MDA significantly increased in all the tissues except in the lungs of rats treated with both dosages of DIC. With regard to the ADS, GR significantly decreased in the erythrocytes whereas it did not change in the other tissues with two dosages of DIC. SOD activity significantly increased in the all tissues treated with both dosages of DIC. GST activity significantly increased in all the tissues except in the erythrocytes, spleen, and lungs treated with 0.0225mmol. Meanwhile, GSH depletion in the liver and heart of rats treated with 0.0225mmol and all the tissues except in the brain and kidney of rats treated with 0.0450mmol of DIC were found to be significant. The observations presented led us to conclude that the administrations of DIC promote MDA content and fluctuate in the ADS in rats during the exposure. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/18539328/Effects_of_subacute_exposure_of_dichlorvos_at_sublethal_dosages_on_erythrocyte_and_tissue_antioxidant_defense_systems_and_lipid_peroxidation_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-6513(08)00110-3 DB - PRIME DP - Unbound Medicine ER -