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Stimulus-driven and strategic neural responses to fearful and happy facial expressions in humans.
Eur J Neurosci. 2008 Jun; 27(11):3074-82.EJ

Abstract

The human amygdala responds selectively to consciously and unconsciously perceived facial expressions, particularly those that convey potential threat such as fear and anger. In many social situations, multiple faces with varying expressions confront observers yet little is known about the neural mechanisms involved in encoding several faces simultaneously. Here we used event-related fMRI to measure neural activity in pre-defined regions of interest as participants searched multi-face arrays for a designated target expression (fearful or happy). We conducted separate analyses to examine activations associated with each of the four multi-face arrays independent of target expression (stimulus-driven effects), and activations arising from the search for each of the target expressions, independent of the display type (strategic effects). Comparisons across display types, reflecting stimulus-driven influences on visual search, revealed activity in the amygdala and superior temporal sulcus (STS). By contrast, strategic demands of the task did not modulate activity in either the amygdala or STS. These results imply an interactive threat-detection system involving several neural regions. Crucially, activity in the amygdala increased significantly when participants correctly detected the target expression, compared with trials in which the identical target was missed, suggesting that the amygdala has a limited capacity for extracting affective facial expressions.

Authors+Show Affiliations

Macquarie Centre for Cognitive Science, Macquarie University, Sydney, NSW 2109, Australia. mark.williams@maccs.mq.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18540880

Citation

Williams, Mark A., et al. "Stimulus-driven and Strategic Neural Responses to Fearful and Happy Facial Expressions in Humans." The European Journal of Neuroscience, vol. 27, no. 11, 2008, pp. 3074-82.
Williams MA, McGlone F, Abbott DF, et al. Stimulus-driven and strategic neural responses to fearful and happy facial expressions in humans. Eur J Neurosci. 2008;27(11):3074-82.
Williams, M. A., McGlone, F., Abbott, D. F., & Mattingley, J. B. (2008). Stimulus-driven and strategic neural responses to fearful and happy facial expressions in humans. The European Journal of Neuroscience, 27(11), 3074-82. https://doi.org/10.1111/j.1460-9568.2008.06264.x
Williams MA, et al. Stimulus-driven and Strategic Neural Responses to Fearful and Happy Facial Expressions in Humans. Eur J Neurosci. 2008;27(11):3074-82. PubMed PMID: 18540880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stimulus-driven and strategic neural responses to fearful and happy facial expressions in humans. AU - Williams,Mark A, AU - McGlone,Francis, AU - Abbott,David F, AU - Mattingley,Jason B, Y1 - 2008/06/06/ PY - 2008/6/11/pubmed PY - 2008/8/21/medline PY - 2008/6/11/entrez SP - 3074 EP - 82 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 27 IS - 11 N2 - The human amygdala responds selectively to consciously and unconsciously perceived facial expressions, particularly those that convey potential threat such as fear and anger. In many social situations, multiple faces with varying expressions confront observers yet little is known about the neural mechanisms involved in encoding several faces simultaneously. Here we used event-related fMRI to measure neural activity in pre-defined regions of interest as participants searched multi-face arrays for a designated target expression (fearful or happy). We conducted separate analyses to examine activations associated with each of the four multi-face arrays independent of target expression (stimulus-driven effects), and activations arising from the search for each of the target expressions, independent of the display type (strategic effects). Comparisons across display types, reflecting stimulus-driven influences on visual search, revealed activity in the amygdala and superior temporal sulcus (STS). By contrast, strategic demands of the task did not modulate activity in either the amygdala or STS. These results imply an interactive threat-detection system involving several neural regions. Crucially, activity in the amygdala increased significantly when participants correctly detected the target expression, compared with trials in which the identical target was missed, suggesting that the amygdala has a limited capacity for extracting affective facial expressions. SN - 1460-9568 UR - https://www.unboundmedicine.com/medline/citation/18540880/Stimulus_driven_and_strategic_neural_responses_to_fearful_and_happy_facial_expressions_in_humans_ L2 - https://doi.org/10.1111/j.1460-9568.2008.06264.x DB - PRIME DP - Unbound Medicine ER -