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The role of BDNF and HPA axis in the neurobiology of burnout syndrome.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 01; 32(6):1459-65.PN

Abstract

Chronic stress is known to affect the HPA axis. The few clinical studies which have been conducted on HPA-axis function in burnout have produced inconsistent results. The etiological relationship between sBDNF and burnout has not yet been studied. The aim of the current study was to investigate the role of BDNF and HPA axis in the neurobiology of burnout. In the current study 37 clinically diagnosed burnout participants were compared with 35 healthy controls in terms of BDNF, HPA axis, burnout symptoms, depression, anxiety and psychosomatic complaints. Basal serum cortisol, sBDNF and cortisol level after 1 mg DST was sampled. We found no significant differences in terms of HPA-axis function (for basal serum cortisol, p=0.592; for cortisol level after 1 mg DST, p=0.921), but we did find lowered sBDNF levels in burnout group (88.66+/-18.15 pg/ml) as compared to healthy controls (102.18+/-20.92 pg/ml) and the difference was statistically significant (p=0.005). Logistic Regression Analysis revealed that emotional exhaustion (p=0.05), depersonalization (p=0.005) and depression (p=0.025) were significantly associated with burnout. sBDNF levels correlated negatively with emotional exhaustion (r=-,268, p=0.026), depersonalization (r=-,333, p=0.005) and correlated positively with competence (r=0.293, p=0.015) sub-scales of burnout inventory. However, there were no significant relationships between cortisol levels and sBDNF levels (r=0.80, p=0.51), depression, anxiety, psychosomatic complaints and burnout inventory. Our results suggest that low BDNF might contribute to the neurobiology of burnout syndrome and it seems to be associated with burnout symptoms including altered mood and cognitive functions.

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Authors+Show Affiliations

Onen Sertoz O
Ege University, School of Medicine, Department of Psychiatry, Division of Consultation Liaison Psychiatry, 35100 Izmir, Turkey. onenozen@hotmail.com
Tolga Binbay I
No affiliation info available
Koylu E
No affiliation info available
Noyan A
No affiliation info available
Yildirim E
No affiliation info available
Elbi Mete H
No affiliation info available

MeSH

AdultBrain-Derived Neurotrophic FactorBurnout, ProfessionalCase-Control StudiesDexamethasoneFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemLogistic ModelsMaleNursesPhysiciansPituitary Function TestsPsychiatric Status Rating ScalesPsychologySurveys and Questionnaires

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18541357

Citation

Onen Sertoz, Ozen, et al. "The Role of BDNF and HPA Axis in the Neurobiology of Burnout Syndrome." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 32, no. 6, 2008, pp. 1459-65.
Onen Sertoz O, Tolga Binbay I, Koylu E, et al. The role of BDNF and HPA axis in the neurobiology of burnout syndrome. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(6):1459-65.
Onen Sertoz, O., Tolga Binbay, I., Koylu, E., Noyan, A., Yildirim, E., & Elbi Mete, H. (2008). The role of BDNF and HPA axis in the neurobiology of burnout syndrome. Progress in Neuro-psychopharmacology & Biological Psychiatry, 32(6), 1459-65. https://doi.org/10.1016/j.pnpbp.2008.05.001
Onen Sertoz O, et al. The Role of BDNF and HPA Axis in the Neurobiology of Burnout Syndrome. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1459-65. PubMed PMID: 18541357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of BDNF and HPA axis in the neurobiology of burnout syndrome. AU - Onen Sertoz,Ozen, AU - Tolga Binbay,Ibrahim, AU - Koylu,Ersin, AU - Noyan,Aysin, AU - Yildirim,Emre, AU - Elbi Mete,Hayriye, Y1 - 2008/05/08/ PY - 2008/02/28/received PY - 2008/04/30/revised PY - 2008/05/01/accepted PY - 2008/6/11/pubmed PY - 2008/10/23/medline PY - 2008/6/11/entrez SP - 1459 EP - 65 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 32 IS - 6 N2 - Chronic stress is known to affect the HPA axis. The few clinical studies which have been conducted on HPA-axis function in burnout have produced inconsistent results. The etiological relationship between sBDNF and burnout has not yet been studied. The aim of the current study was to investigate the role of BDNF and HPA axis in the neurobiology of burnout. In the current study 37 clinically diagnosed burnout participants were compared with 35 healthy controls in terms of BDNF, HPA axis, burnout symptoms, depression, anxiety and psychosomatic complaints. Basal serum cortisol, sBDNF and cortisol level after 1 mg DST was sampled. We found no significant differences in terms of HPA-axis function (for basal serum cortisol, p=0.592; for cortisol level after 1 mg DST, p=0.921), but we did find lowered sBDNF levels in burnout group (88.66+/-18.15 pg/ml) as compared to healthy controls (102.18+/-20.92 pg/ml) and the difference was statistically significant (p=0.005). Logistic Regression Analysis revealed that emotional exhaustion (p=0.05), depersonalization (p=0.005) and depression (p=0.025) were significantly associated with burnout. sBDNF levels correlated negatively with emotional exhaustion (r=-,268, p=0.026), depersonalization (r=-,333, p=0.005) and correlated positively with competence (r=0.293, p=0.015) sub-scales of burnout inventory. However, there were no significant relationships between cortisol levels and sBDNF levels (r=0.80, p=0.51), depression, anxiety, psychosomatic complaints and burnout inventory. Our results suggest that low BDNF might contribute to the neurobiology of burnout syndrome and it seems to be associated with burnout symptoms including altered mood and cognitive functions. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/18541357/The_role_of_BDNF_and_HPA_axis_in_the_neurobiology_of_burnout_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(08)00135-8 DB - PRIME DP - Unbound Medicine ER -