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Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial.
Am J Clin Nutr. 2008 Jun; 87(6):1623-30.AJ

Abstract

BACKGROUND

Plasma apolipoprotein B (apo B) and VLDL and LDL with apolipoprotein C-III (apo C-III) are independent risk factors for cardiovascular disease (CVD). Dietary intake affects lipoprotein concentration and composition related to those apolipoproteins.

OBJECTIVE

We studied differences in apo B lipoproteins with and without apo C-III after 3 healthy diets based on the Dietary Approaches to Stop Hypertension Trial diet.

DESIGN

Healthy participants (n = 162) were fed each of 3 healthy diets for 6 wk in a crossover design. Diets differed by emphasis of either carbohydrate (Carb), unsaturated fat (Unsat), or protein (Prot). Blood was collected at baseline and after diets for analysis.

RESULTS

Compared with the Carb diet, the Prot diet reduced plasma apo B and triglycerides in VLDL with apo C-III (16%, P = 0.07; 11%, P = 0.05, respectively) and apo B in LDL with apo C-III (16%, P = 0.04). Compared with the Unsat diet, the Prot diet reduced triglycerides in VLDL with apo C-III (16%, P = 0.02). Compared with baseline (subjects' usual diet was higher in saturated fat), the Prot diet reduced apo B in LDL with apo C-III (11%, P = 0.05), and all 3 diets reduced plasma total apo B (6-10%, P < 0.05) and apo B in the major type of LDL, LDL without apo C-III (8-10%, P < 0.01). All 3 diets reduced the ratio of apo C-III to apo E in VLDL.

CONCLUSIONS

Substituting protein for carbohydrate in the context of a healthy dietary pattern reduced atherogenic apo C-III-containing LDL and its precursor, apo C-III-containing VLDL, resulting in the most favorable profile of apo B lipoproteins. In addition, compared with a typical high-saturated fat diet, healthy diets that emphasize carbohydrate, protein, or unsaturated fat reduce plasma total and LDL apo B and produce a lower more metabolically favorable ratio of apo C-III to apo E.

Authors+Show Affiliations

Harvard School of Public Health, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18541549

Citation

Furtado, Jeremy D., et al. "Effect of Protein, Unsaturated Fat, and Carbohydrate Intakes On Plasma Apolipoprotein B and VLDL and LDL Containing Apolipoprotein C-III: Results From the OmniHeart Trial." The American Journal of Clinical Nutrition, vol. 87, no. 6, 2008, pp. 1623-30.
Furtado JD, Campos H, Appel LJ, et al. Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial. Am J Clin Nutr. 2008;87(6):1623-30.
Furtado, J. D., Campos, H., Appel, L. J., Miller, E. R., Laranjo, N., Carey, V. J., & Sacks, F. M. (2008). Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial. The American Journal of Clinical Nutrition, 87(6), 1623-30.
Furtado JD, et al. Effect of Protein, Unsaturated Fat, and Carbohydrate Intakes On Plasma Apolipoprotein B and VLDL and LDL Containing Apolipoprotein C-III: Results From the OmniHeart Trial. Am J Clin Nutr. 2008;87(6):1623-30. PubMed PMID: 18541549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial. AU - Furtado,Jeremy D, AU - Campos,Hannia, AU - Appel,Lawrence J, AU - Miller,Edgar R, AU - Laranjo,Nancy, AU - Carey,Vincent J, AU - Sacks,Frank M, PY - 2008/6/11/pubmed PY - 2008/8/2/medline PY - 2008/6/11/entrez SP - 1623 EP - 30 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 87 IS - 6 N2 - BACKGROUND: Plasma apolipoprotein B (apo B) and VLDL and LDL with apolipoprotein C-III (apo C-III) are independent risk factors for cardiovascular disease (CVD). Dietary intake affects lipoprotein concentration and composition related to those apolipoproteins. OBJECTIVE: We studied differences in apo B lipoproteins with and without apo C-III after 3 healthy diets based on the Dietary Approaches to Stop Hypertension Trial diet. DESIGN: Healthy participants (n = 162) were fed each of 3 healthy diets for 6 wk in a crossover design. Diets differed by emphasis of either carbohydrate (Carb), unsaturated fat (Unsat), or protein (Prot). Blood was collected at baseline and after diets for analysis. RESULTS: Compared with the Carb diet, the Prot diet reduced plasma apo B and triglycerides in VLDL with apo C-III (16%, P = 0.07; 11%, P = 0.05, respectively) and apo B in LDL with apo C-III (16%, P = 0.04). Compared with the Unsat diet, the Prot diet reduced triglycerides in VLDL with apo C-III (16%, P = 0.02). Compared with baseline (subjects' usual diet was higher in saturated fat), the Prot diet reduced apo B in LDL with apo C-III (11%, P = 0.05), and all 3 diets reduced plasma total apo B (6-10%, P < 0.05) and apo B in the major type of LDL, LDL without apo C-III (8-10%, P < 0.01). All 3 diets reduced the ratio of apo C-III to apo E in VLDL. CONCLUSIONS: Substituting protein for carbohydrate in the context of a healthy dietary pattern reduced atherogenic apo C-III-containing LDL and its precursor, apo C-III-containing VLDL, resulting in the most favorable profile of apo B lipoproteins. In addition, compared with a typical high-saturated fat diet, healthy diets that emphasize carbohydrate, protein, or unsaturated fat reduce plasma total and LDL apo B and produce a lower more metabolically favorable ratio of apo C-III to apo E. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18541549/Effect_of_protein_unsaturated_fat_and_carbohydrate_intakes_on_plasma_apolipoprotein_B_and_VLDL_and_LDL_containing_apolipoprotein_C_III:_results_from_the_OmniHeart_Trial_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/87.6.1623 DB - PRIME DP - Unbound Medicine ER -