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Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration.
Am J Clin Nutr 2008; 87(6):1837-43AJ

Abstract

BACKGROUND

The association between lutein/zeaxanthin intake and age-related macular degeneration (AMD) risk may differ by smoking status, vitamin C and E intakes, and body fatness.

OBJECTIVE

The objective was to evaluate the association between lutein/zeaxanthin intake and AMD risk by smoking status, intake of antioxidant vitamins, and body fatness.

DESIGN

We conducted a prospective follow-up study of 71 494 women and 41 564 men aged >or=50 y and had no diagnosis of AMD or cancer. Diet was assessed with a validated semiquantitative food-frequency questionnaire.

RESULTS

During up to 18 y of follow-up, we documented 673 incident cases of early AMD and 442 incident cases of neovascular AMD with a visual loss of 20/30 or worse due primarily to AMD. Lutein/zeaxanthin intake was not associated with the risk of self-reported early AMD. There was a statistically nonsignificant and nonlinear inverse association between lutein/zeaxanthin intake and neovascular AMD risk; the pooled multivariate relative risks for increasing quintiles of intake were 1.00 (referent), 0.80, 0.84, 0.97, and 0.72 (95% CI: 0.53, 0.99) (P for trend = 0.14). For early AMD, the association with lutein/zeaxanthin intake did not vary by smoking status, intakes of vitamins C and E, or body mass index. For neovascular AMD, a nonlinear inverse association was found among never smokers.

CONCLUSIONS

These data do not support a protective role of lutein/zeaxanthin intake on risk of self-reported early AMD. The suggestion of inverse associations related to the risk of neovascular AMD needs to be examined further.

Authors+Show Affiliations

Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. eunyoung.cho@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18541575

Citation

Cho, Eunyoung, et al. "Prospective Study of Lutein/zeaxanthin Intake and Risk of Age-related Macular Degeneration." The American Journal of Clinical Nutrition, vol. 87, no. 6, 2008, pp. 1837-43.
Cho E, Hankinson SE, Rosner B, et al. Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. Am J Clin Nutr. 2008;87(6):1837-43.
Cho, E., Hankinson, S. E., Rosner, B., Willett, W. C., & Colditz, G. A. (2008). Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. The American Journal of Clinical Nutrition, 87(6), pp. 1837-43.
Cho E, et al. Prospective Study of Lutein/zeaxanthin Intake and Risk of Age-related Macular Degeneration. Am J Clin Nutr. 2008;87(6):1837-43. PubMed PMID: 18541575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. AU - Cho,Eunyoung, AU - Hankinson,Susan E, AU - Rosner,Bernard, AU - Willett,Walter C, AU - Colditz,Graham A, PY - 2008/6/11/pubmed PY - 2008/8/2/medline PY - 2008/6/11/entrez SP - 1837 EP - 43 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 87 IS - 6 N2 - BACKGROUND: The association between lutein/zeaxanthin intake and age-related macular degeneration (AMD) risk may differ by smoking status, vitamin C and E intakes, and body fatness. OBJECTIVE: The objective was to evaluate the association between lutein/zeaxanthin intake and AMD risk by smoking status, intake of antioxidant vitamins, and body fatness. DESIGN: We conducted a prospective follow-up study of 71 494 women and 41 564 men aged >or=50 y and had no diagnosis of AMD or cancer. Diet was assessed with a validated semiquantitative food-frequency questionnaire. RESULTS: During up to 18 y of follow-up, we documented 673 incident cases of early AMD and 442 incident cases of neovascular AMD with a visual loss of 20/30 or worse due primarily to AMD. Lutein/zeaxanthin intake was not associated with the risk of self-reported early AMD. There was a statistically nonsignificant and nonlinear inverse association between lutein/zeaxanthin intake and neovascular AMD risk; the pooled multivariate relative risks for increasing quintiles of intake were 1.00 (referent), 0.80, 0.84, 0.97, and 0.72 (95% CI: 0.53, 0.99) (P for trend = 0.14). For early AMD, the association with lutein/zeaxanthin intake did not vary by smoking status, intakes of vitamins C and E, or body mass index. For neovascular AMD, a nonlinear inverse association was found among never smokers. CONCLUSIONS: These data do not support a protective role of lutein/zeaxanthin intake on risk of self-reported early AMD. The suggestion of inverse associations related to the risk of neovascular AMD needs to be examined further. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18541575/Prospective_study_of_lutein/zeaxanthin_intake_and_risk_of_age_related_macular_degeneration_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/87.6.1837 DB - PRIME DP - Unbound Medicine ER -